Active hydroxymetabolites of antidepressants. Emphasis on E-10-hydroxy-nortriptyline (Q40504522)

21 September 2017

1 reference

title

Active hydroxymetabolites of antidepressants. Emphasis on E-10-hydroxy-nortriptyline (English)

1 reference

21 September 2017

C Nordin

1

1 reference

PubMed ID

7712660

21 September 2017

L Bertilsson

series ordinal

2

1 reference

21 September 2017

1 January 1995

1 reference

Clinical Pharmacokinetics

21 September 2017

1 reference

21 September 2017

28

1 reference

21 September 2017

1

1 reference

21 September 2017

26-40

1 reference

https://scigraph.springernature.com/pub.10.2165/00003088-199528010-00004

21 September 2017

0 references

cites work

Plasma level monitoring of antidepressants: theoretical basis and clinical application.

1 reference

12 December 2020

Determination of clomipramine and its hydroxylated and demethylated metabolites in plasma and urine by liquid chromatography with electrochemical detection

1 reference

12 December 2020

Affinity of nortriptyline and its E-10-hydroxy metabolite for muscarinic receptors.

1 reference

12 December 2020

Polymorphic oxidation of sparteine and debrisoquine: Related pharmacogenetic entities

1 reference

12 December 2020

Plasma 10-hydroxynortriptyline and therapeutic response in geriatric depression

1 reference

12 December 2020

Slow hydroxylation of nortriptyline and concomitant poor debrisoquine hydroxylation: clinical implications

1 reference

12 December 2020

Hydroxylated metabolites of tricyclic antidepressants: preclinical assessment of activity

1 reference

12 December 2020

Enantioselective formation and disposition of (E)- and (Z)-10-hydroxynortriptyline

1 reference

12 December 2020

The debrisoquine hydroxylation test predicts steady-state plasma levels of desipramine

1 reference

12 December 2020

Active metabolites of antidepressants: pharmacodynamics and relevant pharmacokinetics

1 reference

12 December 2020

5-Hydroxyindoleacetic acid in cerebrospinal fluid--methodological and clinical aspects

1 reference

12 December 2020

Hydroxylated metabolites of antidepressants

1 reference

12 December 2020

Importance of oxidative polymorphism and levomepromazine treatment on the steady-state blood concentrations of clomipramine and its major metabolites

1 reference

12 December 2020

Stereoselective Efflux of (E)-10-Hydroxynortriptyline Enantiomers from the Cerebrospinal Fluid of Depressed Patients

1 reference

12 December 2020

Electrocardiographic changes with nortriptyline and 10-hydroxynortriptyline in elderly depressed outpatients

1 reference

12 December 2020

Phenotypic consistency in hydroxylation of desmethylimipramine and debrisoquine in healthy subjects and in human liver microsomes

1 reference

12 December 2020

Molecular structure and dynamics of the four 10-hydroxynortriptyline isomers

1 reference

12 December 2020

Enantiomer analysis of E- and Z-10-hydroxyamitriptyline in human urine

1 reference

12 December 2020

E- and Z-10-hydroxylation of nortriptyline: relationship to polymorphic debrisoquine hydroxylation

1 reference

12 December 2020

The analgesic activity of morphine-6-glucuronide

1 reference

12 December 2020

Heart failure associated with high plasma 10-hydroxynortriptyline levels.

1 reference

12 December 2020

Nortriptyline and antipyrine clearance in relation to debrisoquine hydroxylation in man

1 reference

12 December 2020

Plasma concentrations of nortriptyline and its 10-hydroxy metabolite in depressed patients--relationship to the debrisoquine hydroxylation metabolic ratio

1 reference

12 December 2020

Glucuronidation of the enantiomers of E-10-hydroxynortriptyline in human and rat liver microsomes

1 reference

12 December 2020

Glucuronidation of E-10-hydroxynortriptyline in human liver, kidney, and intestine. Organ-specific differences in enantioselectivity

1 reference

12 December 2020

CSF and plasma levels of nortriptyline and its 10-hydroxy metabolite

1 reference

12 December 2020

Serotonin uptake inhibition during treatment of depression with nortriptyline caused by parent drug and not by 10-hydroxymetabolites

1 reference

12 December 2020

Effects of nortriptyline and its 10-hydroxy metabolite on plasma noradrenaline (NA) concentrations, heart rate and blood pressure during intravenous NA infusion

1 reference

12 December 2020

Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine

1 reference

12 December 2020

Antidepressive effect and pharmacokinetics of amitriptyline with consideration of unbound drug and 10-hydroxynortriptyline plasma levels

1 reference

12 December 2020

High‐Performance Liquid Chromatographic Assay for Imipramine, Desipramine, and Their 2‐Hydroxylated Metabolites

1 reference

12 December 2020

Steady-state plasma levels of E- and Z-10-OH-nortriptyline in nortriptyline-treated patients: significance of concurrent medication and the sparteine oxidation phenotype.

1 reference

12 December 2020

Weak binding of 10-hydroxymetabolites of nortriptyline to rat brain muscarinic acetylcholine receptors.

1 reference

12 December 2020

Plasma 10-hydroxynortriptyline and ECG changes in elderly depressed patients.

1 reference

12 December 2020

Imipramine: Clinical effects and pharmacokinetic variability

1 reference

12 December 2020

Plasma 10-hydroxynortriptyline in elderly depressed patients

1 reference

12 December 2020

Extremely rapid hydroxylation of debrisoquine: a case report with implication for treatment with nortriptyline and other tricyclic antidepressants.

1 reference

12 December 2020

Antidepressants and the Muscarinic Acetylcholine Receptor

1 reference

12 December 2020

Stereoselective disposition of racemic E-10-hydroxynortriptyline in human beings

1 reference

12 December 2020

Prediction of steady-state plasma levels of nortriptyline from single oral dose kinetics: a study in twins.

1 reference

12 December 2020

Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes

1 reference

12 December 2020

A New Depression Scale Designed to be Sensitive to Change

1 reference

12 December 2020

Ion-pair liquid chromatography of amitriptyline and metabolites in plasma

1 reference

12 December 2020

Clinical and biochemical effects during treatment of depression with nortriptyline: the role of 10-hydroxynortriptyline

1 reference

12 December 2020

Nortriptyline and 10-hydroxynortriptyline plasma concentrations

1 reference

12 December 2020

Verbal memory and plasma drug concentrations in elderly depressives treated with nortriptyline.

1 reference

12 December 2020

Treatment of depression with E-10-hydroxynortriptyline--a pilot study on biochemical effects and pharmacokinetics

1 reference

12 December 2020

Clinical implications of 2-hydroxydesipramine plasma concentrations

1 reference

12 December 2020

Pronounced inhibition of noradrenaline uptake by 10-hydroxymetabolites of nortriptyline

1 reference

12 December 2020

Polymorphic hydroxylation of Debrisoquine in man.

1 reference

12 December 2020

Interindividual differences in amitriptyline demethylation

1 reference

12 December 2020

Stereoselective inhibition of nortriptyline hydroxylation in man by quinidine

1 reference

12 December 2020

Amitriptyline pharmacokinetics and clinical response: II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin

1 reference

12 December 2020

Little anticholinergic effect of E-10-hydroxynortriptyline compared with nortriptyline in healthy subjects

1 reference

12 December 2020

Amitriptyline metabolites in human urine. Identification of phenols, dihydrodiols, glycols, and ketones

1 reference

12 December 2020

Comparative cardiotoxicity of nortriptyline and its isomeric 10-hydroxymetabolites

1 reference

12 December 2020

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

1 reference

12 December 2020

CSF/plasma ratio of 10-hydroxynortriptyline is influenced by sex and body height

1 reference

12 December 2020

Role of oxidation polymorphism on blood and urine concentrations of amitriptyline and its metabolites in man

1 reference

12 December 2020

Relationship between plasma level and therapeutic effect of nortriptyline.

1 reference

12 December 2020

Clinical significance of the sparteine/debrisoquine oxidation polymorphism

1 reference

12 December 2020

Steady-state plasma levels of nortriptyline in twins: influence of genetic factors and drug therapy

1 reference

12 December 2020

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine

1 reference

12 December 2020

Disposition of single oral doses of E-10-hydroxynortriptyline in healthy subjects, with some observations on pharmacodynamic effects

1 reference

12 December 2020

Enantioselective hydroxylation of nortriptyline in human liver microsomes, intestinal homogenate, and patients treated with nortriptyline

1 reference

12 December 2020

10.2165/00003088-199528010-00004

Identifiers

DOI

1 reference

PubMed ID

7712660

Dimensions Publication ID

21 September 2017

0 references

1 reference

PubMed ID

7712660