Drug synthesis by genetically engineered microorganisms (Q40534399)

21 September 2017

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title

Drug synthesis by genetically engineered microorganisms (English)

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21 September 2017

Hutchinson CR

1

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21 September 2017

publication date

1 April 1994

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21 September 2017

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21 September 2017

volume

12

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21 September 2017

issue

4

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21 September 2017

page(s)

375-380

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Homology between Streptomyces genes coding for synthesis of different polyketides used to clone antibiotic biosynthetic genes

21 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

Evolution of Salmonella O antigen variation by interspecific gene transfer on a large scale

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

Production of a hybrid macrolide antibiotic in Streptomyces ambofaciens and Streptomyces lividans by introduction of a cloned carbomycin biosynthetic gene from Streptomyces thermotolerans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

Overproduction of soluble trichodiene synthase from Fusarium sporotrichioides in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

Primary structure of AfsR, a global regulatory protein for secondary metabolite formation in Streptomyces coelicolor A3(2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

The generation of molecular diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

Production of 2-Keto-L-Gulonate, an Intermediate in L-Ascorbate Synthesis, by a Genetically Modified Erwinia herbicola

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Construction of metabolic operons catalyzing the de novo biosynthesis of indigo in Escherichia coli.

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Isolation of deacetoxycephalosporin C from fermentation broths of Penicillium chrysogenum transformants: construction of a new fungal biosynthetic pathway

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Speeding Up a Chemical Game of Chance

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Encoded combinatorial chemistry

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Modular organization of genes required for complex polyketide biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Gene probes for the detection of 6-deoxyhexose metabolism in secondary metabolite-producing streptomycetes

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

A macrolide 3-O-acyltransferase gene from the midecamycin-producing species Streptomyces mycarofaciens

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Nucleotide sequences and heterologous expression of tcmG and tcmP, biosynthetic genes for tetracenomycin C in Streptomyces glaucescens

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Cloning and sequencing of a gene encoding carminomycin 4-O-methyltransferase from Streptomyces peucetius and its expression in Escherichia coli

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

New antibiotics from genetically engineered actinomycetes. I. 2-Norerythromycins, isolation and structural determinations

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

An erythromycin analog produced by reprogramming of polyketide synthesis

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Chemical modification of erythromycins. I. Synthesis and antibacterial activity of 6-O-methylerythromycins A

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Identification of a Saccharopolyspora erythraea gene required for the final hydroxylation step in erythromycin biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferases

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Substrate specificity of 6-deoxyerythronolide B hydroxylase, a bacterial cytochrome P450 of erythromycin A biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Substrate specificity of isopenicillin N synthase

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Gamma-lactam analogues of beta-lactam antibiotics

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Engineered biosynthesis of novel polyketides

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Enzymatic synthesis of a bacterial polyketide from acetyl and malonyl coenzyme A

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Stereospecific acyl transfers on the erythromycin-producing polyketide synthase

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Transcriptional regulation of bialaphos biosynthesis in Streptomyces hygroscopicus

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Overproduction of the acyl carrier protein component of a type II polyketide synthase stimulates production of tetracenomycin biosynthetic intermediates in Streptomyces glaucescens

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Plasmid effects on secondary metabolite production by a streptomycete synthesizing an anthelmintic macrolide

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Precursor flux control through targeted chromosomal insertion of the lysine epsilon-aminotransferase (lat) gene in cephamycin C biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Inhibition of erythromycin synthesis by disruption of malonyl-coenzyme A decarboxylase gene eryM in Saccharopolyspora erythraea

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Sequence, transcriptional, and functional analyses of the valine (branched-chain amino acid) dehydrogenase gene of Streptomyces coelicolor

1 reference

https://api.crossref.org/works/10.1038%2FNBT0494-375

7 January 2021

Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tü22.

1 reference

9 March 2024

https://opencitations.net/index/api/v1/citations/10.1002/J.1460-2075.1989.TB08413.X

Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.

1 reference

9 March 2024

https://opencitations.net/index/api/v1/citations/10.1002/J.1460-2075.1989.TB08414.X

Identifiers

DOI

10.1038/NBT0494-375

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21 September 2017

1 reference