Processing amyloid precursor protein at the beta-site requires proper orientation to be accessed by BACE1. (Q40539017)

21 September 2017

title

Processing amyloid precursor protein at the beta-site requires proper orientation to be accessed by BACE1. (English)

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21 September 2017

Isam Qahwash

1

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21 September 2017

Wanxia He

2

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21 September 2017

Alfredo Tomasselli

3

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21 September 2017

Rolf F Kletzien

4

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21 September 2017

Riqiang Yan

5

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21 September 2017

language of work or name

English

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publication date

2 July 2004

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Journal of Biological Chemistry

21 September 2017

published in

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21 September 2017

volume

279

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21 September 2017

issue

37

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21 September 2017

page(s)

39010-39016

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Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

21 September 2017

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21 January 2018

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21 January 2018

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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

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The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain

21 January 2018

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Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

21 January 2018

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Processing of beta-secretase by furin and other members of the proprotein convertase family

21 January 2018

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A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

21 January 2018

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Maturation and pro-peptide cleavage of beta-secretase

21 January 2018

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The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

21 January 2018

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Phosphorylation regulates intracellular trafficking of beta-secretase

21 January 2018

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The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

21 January 2018

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

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Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain

21 January 2018

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Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression

21 January 2018

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Employing a superior BACE1 cleavage sequence to probe cellular APP processing

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

21 January 2018

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The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

21 January 2018

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Solution structures of micelle-bound amyloid beta-(1-40) and beta-(1-42) peptides of Alzheimer's disease

21 January 2018

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Solution structure of the Alzheimer amyloid beta-peptide (1-42) in an apolar microenvironment. Similarity with a virus fusion domain

21 January 2018

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21 January 2018

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21 January 2018

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beta-Amyloid peptide vaccination results in marked changes in serum and brain Abeta levels in APPswe/PS1DeltaE9 mice, as detected by SELDI-TOF-based ProteinChip technology

21 January 2018

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Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes

21 January 2018

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M407101200

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21 September 2017

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