AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease (Q40560840)

21 September 2017

AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease (English)

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21 September 2017

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Deborah Young

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Bronwen Connor

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Bronwen Connor

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author name string

Adrian P Kells

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21 September 2017

Dahna M Fong

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21 September 2017

Mike Dragunow

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21 September 2017

Matthew J During

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21 September 2017

1 May 2004

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21 September 2017

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21 September 2017

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21 September 2017

682-688

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21 September 2017

5

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

The selective vulnerability of nerve cells in Huntington's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Brain-derived neurotrophic factor in Huntington disease

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Excitatory amino acids differentially regulate the expression of GDNF, neurturin, and their receptors in the adult rat striatum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Reactive astrocytes of the quinolinic acid-lesioned rat striatum express GFRalpha1 as well as GDNF in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Protection of the neostriatum against excitotoxic damage by neurotrophin-producing, genetically modified neural stem cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Local protective effects of nerve growth factor-secreting fibroblasts against excitotoxic lesions in the rat striatum

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Implants of encapsulated human CNTF-producing fibroblasts prevent behavioral deficits and striatal degeneration in a rodent model of Huntington's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Cellular delivery of human CNTF prevents motor and cognitive dysfunction in a rodent model of Huntington's disease

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Cellular delivery of CNTF but not NT-4/5 prevents degeneration of striatal neurons in a rodent model of Huntington's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Ciliary neurotrophic factor protects striatal output neurons in an animal model of Huntington disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

The IGF-I amino-terminal tripeptide glycine-proline-glutamate (GPE) is neuroprotective to striatum in the quinolinic acid lesion animal model of Huntington's disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Administration of recombinant human Activin-A has powerful neurotrophic effects on select striatal phenotypes in the quinolinic acid lesion model of Huntington's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

The neurotrophins BDNF, NT-3 and NT-4/5 promote survival and morphological and biochemical differentiation of striatal neurons in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Brain-derived neurotrophic factor promotes differentiation of striatal GABAergic neurons

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Trophic and protective actions of brain-derived neurotrophic factor on striatal DARPP-32-containing neurons in vitro.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Glial cell line-derived neurotrophic factor attenuates the excitotoxin-induced behavioral and neurochemical deficits in a rodent model of Huntington's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Intrastriatal grafting of a GDNF-producing cell line protects striatonigral neurons from quinolinic acid excitotoxicity in vivo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Glial cell line-derived neurotrophic factor protects striatal calbindin-immunoreactive neurons from excitotoxic damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Adeno-associated virus vectors: activity and applications in the CNS.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Structural and functional neuroprotection in a rat model of Huntington's disease by viral gene transfer of GDNF.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Brain-derived neurotrophic factor-mediated protection of striatal neurons in an excitotoxic rat model of Huntington's disease, as demonstrated by adenoviral gene transfer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Ultrastructural localization of full-length trkB immunoreactivity in rat hippocampus suggests multiple roles in modulating activity-dependent synaptic plasticity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Neurotrophin signal transduction by the Trk receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Evidence for calcium-reducing and excitoprotective roles for the calcium-binding protein calbindin-1328k in cultured hippocampal neurons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Neuroprotective mechanism of glial cell line-derived neurotrophic factor in mesencephalic neurons.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Glial cell line-derived neurotrophic factor-stimulated phosphatidylinositol 3-kinase and Akt activities exert opposing effects on the ERK pathway: importance for the rescue of neuroectodermic cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Neuroprotection by neurotrophins and GDNF family members in the excitotoxic model of Huntington's disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Characterization of a multicomponent receptor for GDNF.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Neurturin protects striatal projection neurons but not interneurons in a rat model of Huntington's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Striatopallidal neurons are selectively protected by neurturin in an excitotoxic model of Huntington's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Chemical and anatomical changes in the striatum and substantia nigra following quinolinic acid lesions in the striatum of the rat: a detailed time course of the cellular and GABA(A) receptor changes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

No evidence for preservation of somatostatin-containing neurons after intrastriatal injections of quinolinic acid

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Relative resistance of striatal neurons containing calbindin or parvalbumin to quinolinic acid-mediated excitotoxicity compared to other striatal neuron types.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Differential sensitivity of calbindin and parvalbumin immunoreactive cells in the striatum to excitotoxins.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Trophic actions of transforming growth factor alpha on mesencephalic dopaminergic neurons developing in culture

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Protective effects of neurotrophin-4/5 and transforming growth factor-alpha on striatal neuronal phenotypic degeneration after excitotoxic lesioning with quinolinic acid

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Effects of biologically delivered NGF, BDNF and bFGF on striatal excitotoxic lesions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.02.016

10.1016/J.YMTHE.2004.02.016

7 January 2021

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DOI

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21 September 2017

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