HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis (Q40561974)

21 September 2017

HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis (English)

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21 September 2017

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Mamuka Kvaratskhelia

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21 September 2017

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Paul D Bieniasz

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21 September 2017

Jacques J Kessl

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Sebla B Kutluay

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21 September 2017

Dana Townsend

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21 September 2017

Stephanie Rebensburg

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21 September 2017

Alison Slaughter

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21 September 2017

Ross C Larue

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21 September 2017

Nikoloz Shkriabai

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21 September 2017

Nordine Bakouche

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21 September 2017

James R Fuchs

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21 September 2017

language of work or name

English

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publication date

1 August 2016

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21 September 2017

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166

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5

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1257-1268.e12

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describes a project that uses

21 September 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5003418/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Nucleocapsid Protein: A Desirable Target for Future Therapies Against HIV-1.

22 September 2017

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22 September 2017

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The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase

22 September 2017

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Global changes in the RNA binding specificity of HIV-1 gag regulate virion genesis

22 September 2017

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22 September 2017

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A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase

22 September 2017

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The allosteric HIV-1 integrase inhibitor BI-D affects virion maturation but does not influence packaging of a functional RNA genome

22 September 2017

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TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism

22 September 2017

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Allosteric Inhibition of Human Immunodeficiency Virus Integrase

22 September 2017

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Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1

22 September 2017

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A new class of multimerization selective inhibitors of HIV-1 integrase

22 September 2017

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Gene regulation by structured mRNA elements

22 September 2017

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Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage

22 September 2017

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Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells

22 September 2017

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The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

22 September 2017

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Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation

22 September 2017

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Dialysis purification of integrase-DNA complexes provides high-resolution atomic force microscopy images: dimeric recombinant HIV-1 integrase binding and specific looping on DNA.

22 September 2017

1 reference

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HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor

22 September 2017

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Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

22 September 2017

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22 September 2017

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FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75.

22 September 2017

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Structural insights into the retroviral DNA integration apparatus.

22 September 2017

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Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

22 September 2017

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Nucleoprotein intermediates in HIV-1 DNA integration visualized by atomic force microscopy

22 September 2017

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Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

22 September 2017

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Structural analysis of protein-RNA interactions with mass spectrometry

22 September 2017

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Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein

22 September 2017

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The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication

22 September 2017

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Structure-guided peptidomimetic design leads to nanomolar beta-hairpin inhibitors of the Tat-TAR interaction of bovine immunodeficiency virus

22 September 2017

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An essential role for LEDGF/p75 in HIV integration

22 September 2017

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A dominant block to HIV-1 replication at reverse transcription in simian cells

22 September 2017

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

22 September 2017

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Oligomeric states of the HIV-1 integrase as measured by time-resolved fluorescence anisotropy

22 September 2017

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In vivo analysis of retroviral integrase structure and function

22 September 2017

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Lack of integrase can markedly affect human immunodeficiency virus type 1 particle production in the presence of an active viral protease

22 September 2017

1 reference

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Isolation of high-affinity RNA ligands to HIV-1 integrase from a random pool

22 September 2017

1 reference

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Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication

22 September 2017

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

22 September 2017

1 reference

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A novel Vpr peptide interactor fused to integrase (IN) restores integration activity to IN-defective HIV-1 virions

22 September 2017

1 reference

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LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

25 September 2017

1 reference

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LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro

25 September 2017

1 reference

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Role of the trans-activation response element in dimerization of HIV-1 RNA.

17 June 2018

1 reference

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Magnetic anisotropy considerations in magnetic force microscopy studies of single superparamagnetic nanoparticles.

17 June 2018

1 reference

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The TAR hairpin of human immunodeficiency virus type 1 can be deleted when not required for Tat-mediated activation of transcription

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5003418

HIV-1 infection requires a functional integrase NLS.

20 August 2018

1 reference

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Carbon nanotubes: a promising standard for quantitative evaluation of AFM tip apex geometry

20 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27565348

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2016.07.044

1 reference

21 September 2017

1 reference

21 September 2017

PubMed publication ID

27565348

1 reference