Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Cdelta (Q40563515)

21 September 2017

Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Cdelta (English)

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21 September 2017

2

Michelle A Digman

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21 September 2017

Robert V Stahelin

1

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21 September 2017

Martina Medkova

3

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21 September 2017

Bharath Ananthanarayanan

4

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21 September 2017

John D Rafter

5

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21 September 2017

Heather R Melowic

6

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21 September 2017

Wonhwa Cho

7

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21 September 2017

language of work or name

English

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publication date

22 April 2004

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Journal of Biological Chemistry

21 September 2017

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21 September 2017

279

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21 September 2017

28

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21 September 2017

29501-29512

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Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions

21 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Tissue and cellular distribution of the extended family of protein kinase C isoenzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

The proteolytic cleavage of protein kinase C isotypes, which generates kinase and regulatory fragments, correlates with Fas-mediated and 12-O-tetradecanoyl-phorbol-13-acetate-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

The catalytic domain of protein kinase C-delta in reciprocal delta and epsilon chimeras mediates phorbol ester-induced macrophage differentiation of mouse promyelocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Protein kinase C-delta is a negative regulator of antigen-induced mast cell degranulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Peroxisome proliferator-activated receptor gamma ligands inhibit mitogenic induction of p21(Cip1) by modulating the protein kinase Cdelta pathway in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Localization, anchoring, and functions of protein kinase C isozymes in the heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Protein kinase C delta (PKC delta): activation mechanisms and functions

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M403191200

Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Multiple pathways control protein kinase C phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Protein kinase C is regulated in vivo by three functionally distinct phosphorylations

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M403191200

Phosphorylation sites of protein kinase C delta in H2O2-treated cells and its activation by tyrosine kinase in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Requirements of protein kinase cdelta for catalytic function. Role of glutamic acid 500 and autophosphorylation on serine 643

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Phosphorylation of protein kinase Cdelta (PKCdelta) at threonine 505 is not a prerequisite for enzymatic activity. Expression of rat PKCdelta and an alanine 505 mutant in bacteria in a functional form

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Nuclear import of PKCdelta is required for apoptosis: identification of a novel nuclear import sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Novel "nonkinase" phorbol ester receptors: the C1 domain connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Divergence and complexities in DAG signaling: looking beyond PKC

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M403191200

Membrane targeting by C1 and C2 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

The C2 domain calcium-binding motif: structural and functional diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

C2-domains, structure and function of a universal Ca2+-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Activation mechanisms of conventional protein kinase C isoforms are determined by the ligand affinity and conformational flexibility of their C1 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

A structure-function study of the C2 domain of cytosolic phospholipase A2. Identification of essential calcium ligands and hydrophobic membrane binding residues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Membrane binding assays for peripheral proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Roles of ionic residues of the C1 domain in protein kinase C-alpha activation and the origin of phosphatidylserine specificity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Differential roles of ionic, aliphatic, and aromatic residues in membrane-protein interactions: a surface plasmon resonance study on phospholipases A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Roles of calcium ions in the membrane binding of C2 domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

The molecular basis of differential subcellular localization of C2 domains of protein kinase C-alpha and group IVa cytosolic phospholipase A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Interaction of proteins with lipid headgroups: lessons from protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Low affinity binding of phorbol esters to protein kinase C and its recombinant cysteine-rich region in the absence of phospholipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Surface plasmon resonance spectroscopy: an emerging tool for the study of peptide-membrane interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Surface plasmon resonance spectroscopy in the study of membrane-mediated cell signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Phosphatidylinositol 3-phosphate induces the membrane penetration of the FYVE domains of Vps27p and Hrs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Membrane binding mechanisms of the PX domains of NADPH oxidase p40phox and p47phox

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Protein kinase C. Seeing two domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Mutagenesis of the C2 domain of protein kinase C-alpha. Differential roles of Ca2+ ligands and membrane binding residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Structure of the C2 domain from novel protein kinase Cepsilon. A membrane binding model for Ca(2+)-independent C2 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Membrane translocation of novel protein kinase Cs is regulated by phosphorylation of the C2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Crystal structure of the C2 domain from protein kinase C-delta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Non-equivalent roles for the first and second zinc fingers of protein kinase Cdelta. Effect of their mutation on phorbol ester-induced translocation in NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Differential localization of protein kinase C delta by phorbol esters and related compounds using a fusion protein with green fluorescent protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Role of hydrophobic residues in the C1b domain of protein kinase C delta on ligand and phospholipid interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Recombinant C1b domain of PKCdelta triggers meiotic maturation upon microinjection in Xenopus laevis oocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Protein kinase Calpha contains two activator binding sites that bind phorbol esters and diacylglycerols with opposite affinities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Protein kinase C-delta C2-like domain is a binding site for actin and enables actin redistribution in neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Tyrosine phosphorylation-dependent and -independent associations of protein kinase C-delta with Src family kinases in the RBL-2H3 mast cell line: regulation of Src family kinase activity by protein kinase C-delta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Ca(2+) bridges the C2 membrane-binding domain of protein kinase Calpha directly to phosphatidylserine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Membrane targeting of C2 domains of phospholipase C-delta isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Molecular basis of the specific subcellular localization of the C2-like domain of 5-lipoxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Activation and mitochondrial translocation of protein kinase Cdelta are necessary for insulin stimulation of pyruvate dehydrogenase complex activity in muscle and liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Spatial and temporal regulation of protein kinase D (PKD)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

Protein Kinase C δ Inhibits the Proliferation of Vascular Smooth Muscle Cells by Suppressing G1Cyclin Expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403191200

21 January 2018

Identifiers

DOI

10.1074/JBC.M403191200

1 reference

21 September 2017

1 reference