Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1beta (Q40570825)

21 September 2017

Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1beta (English)

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21 September 2017

6

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21 September 2017

Geertrui Denecker

2

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Peter Vandenabeele

object named as

Peter Vandenabeele

4

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author name string

Peter Schotte

1

1 reference

21 September 2017

Aeke Van Den Broeke

3

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21 September 2017

Guy R Cornelis

5

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21 September 2017

language of work or name

English

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publication date

1 April 2004

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Journal of Biological Chemistry

21 September 2017

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21 September 2017

279

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21 September 2017

24

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21 September 2017

25134-25142

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The Yersinia Ysc-Yop 'type III' weaponry

21 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

The RhoGAP activity of the Yersinia pseudotuberculosis cytotoxin YopE is required for antiphagocytic function and virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

The Yersinia protein kinase A is a host factor inducible RhoA/Rac-binding virulence factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

Yersinia enterocolitica impairs activation of transcription factor NF-kappaB: involvement in the induction of programmed cell death and in the suppression of the macrophage tumor necrosis factor alpha production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

The yopJ locus is required for Yersinia-mediated inhibition of NF-kappaB activation and cytokine expression: YopJ contains a eukaryotic SH2-like domain that is essential for its repressive activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

Yersinia enterocolitica YopP-induced apoptosis of macrophages involves the apoptotic signaling cascade upstream of bid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

YopH prevents monocyte chemoattractant protein 1 expression in macrophages and T-cell proliferation through inactivation of the phosphatidylinositol 3-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

The yersinia virulence factor YopM forms a novel protein complex with two cellular kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

Regulation of mRNA expression in macrophages after Yersinia enterocolitica infection. Role of different Yop effectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

The role of the interleukin-1/Toll-like receptor superfamily in inflammation and host defence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

Involvement of NF-kappaB p50/p65 heterodimer in activation of the human pro-interleukin-1beta gene at two subregions of the upstream enhancer element

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

The PYRIN-CARD protein ASC is an activating adaptor for caspase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

NODs: intracellular proteins involved in inflammation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

Identification of the YopE and YopH domains required for secretion and internalization into the cytosol of macrophages, using the cyaA gene fusion approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

Yersinia enterocolitica induces apoptosis in macrophages by a process requiring functional type III secretion and translocation mechanisms and involving YopP, presumably acting as an effector protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

YopT, a new Yersinia Yop effector protein, affects the cytoskeleton of host cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

YopE of Yersinia, a GAP for Rho GTPases, selectively modulates Rac-dependent actin structures in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

A bacterial type III secretion system inhibits actin polymerization to prevent pore formation in host cell membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

Development of a simple, sensitive and specific bioassay for interleukin-1 based on the proliferation of RPMI 1788 cells. Comparison with other bioassays for IL-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

A method for determining the cytoprotective effect of catalase in transiently transfected cell lines and in corneal tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

A highly sensitive cytotoxicity assay based on the release of reporter enzymes, from stably transfected cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

Identification of p130Cas as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

The Yersinia tyrosine phosphatase YopH targets a novel adhesion-regulated signalling complex in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

The PTPase YopH inhibits uptake of Yersinia, tyrosine phosphorylation of p130Cas and FAK, and the associated accumulation of these proteins in peripheral focal adhesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

Role of Yops and adhesins in resistance of Yersinia enterocolitica to phagocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

Characterization of YopT effects on Rho GTPases in Yersinia enterocolitica-infected cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

Clostridium difficile toxins attack Rho.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

Rho GTPases and their effector proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

A balance of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

Bacterial virulence factors targeting Rho GTPases: parasitism or symbiosis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401245200

21 January 2018

Identifiers

DOI

10.1074/JBC.M401245200

1 reference

21 September 2017

1 reference