Polymer conjugates. Pharmacokinetic considerations for design and development (Q40579202)

21 September 2017

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title

Polymer conjugates. Pharmacokinetic considerations for design and development (English)

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21 September 2017

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R Duncan

1

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PubMed ID

7834965

21 September 2017

F Spreafico

series ordinal

2

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21 September 2017

1 October 1994

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Clinical Pharmacokinetics

21 September 2017

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21 September 2017

27

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21 September 2017

290-306

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21 September 2017

4

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https://scigraph.springernature.com/pub.10.2165/00003088-199427040-00004

21 September 2017

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cites work

Modification of batroxobin with activated polyethylene glycol: Reduction of binding ability towards anti-batroxobin antibody and retention of defibrinogenation activity in circulation of preimmunized dogs

1 reference

12 December 2020

Pharmacology of Escherichia coli-L-asparaginase polyethylene glycol adduct

1 reference

12 December 2020

Commentary. Lysosomotropic agents

1 reference

12 December 2020

Superoxide dismutase prevents lipid peroxidation in burned patients

1 reference

12 December 2020

Improving the outcome of severe head injury with the oxygen radical scavenger polyethylene glycol-conjugated superoxide dismutase: a phase II trial

1 reference

12 December 2020

A phase II trial of PEG-L-asparaginase in the treatment of non-Hodgkins lymphoma

1 reference

12 December 2020

Modification of human hemoglobin with polyethylene glycol : a new candidate for blood substitute

1 reference

12 December 2020

Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers.

1 reference

12 December 2020

Modification of hemoglobin upon covalent coupling to dextran: enhanced stability against acid denaturation and reduced affinity for haptoglobin

1 reference

12 December 2020

Effect of arterial administration of high-molecular-weight anticancer agent SMANCS with lipid lymphographic agent on hepatoma: a preliminary report

1 reference

12 December 2020

PEG superoxide dismutase derivatives: anti-inflammatory activity in carrageenan pelurisy in rats

1 reference

12 December 2020

Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol

1 reference

12 December 2020

Characterization of polyethylene glycol-modified L-asparaginase from Escherichia coli and its application to therapy of leukemia

1 reference

12 December 2020

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs

1 reference

12 December 2020

Preparation and properties of polyethylene glycol-trypsin adducts

1 reference

12 December 2020

The effect of chemical modification of L-asparaginase on its persistence in circulating blood of animals

1 reference

12 December 2020

Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing adriamycin. Immunogenicity, and effect on haematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro

1 reference

12 December 2020

Drug-polymer conjugates: potential for improved chemotherapy

1 reference

12 December 2020

Pharmacokinetics of recombinant interleukin 2 in humans

1 reference

12 December 2020

Binding of Covalent Proteins to Polysaccharides by Cyanogen Bromide and Organic Cyanates. I. Preparation of Soluble Glycine-, Insulin- and Ampicillin-dextran

1 reference

12 December 2020

Preclinical trials with combinations and conjugates of T101 monoclonal antibody and doxorubicin

1 reference

12 December 2020

Immunologic responses to conjugates of antigen E in patients with ragweed hay fever

1 reference

12 December 2020

Controlled biodegradability of polymers — a key to drug delivery systems

1 reference

12 December 2020

Tyrosinamide residues enhance pinocytic capture of N-(2-hydroxypropyl)methacrylamide copolymers

1 reference

12 December 2020

Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. II. Evaluation of daunomycin conjugates in vivo against L1210 leukaemia

1 reference

12 December 2020

Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood

1 reference

12 December 2020

Comparison of the liver subcellular distribution of free daunomycin and that bound to galactosamine targeted N-(2-hydroxypropyl)methacrylamide copolymers, following intravenous administration in the rat

1 reference

12 December 2020

Treatment of adenosine deaminase deficiency with polyethylene glycol-modified adenosine deaminase

1 reference

12 December 2020

Enhanced plasma persistence of therapeutic enzymes by coupling to soluble dextran

1 reference

12 December 2020

Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier.

1 reference

12 December 2020

Distribution and mechanism of clearance of L-asparaginase (NSC-109229).

1 reference

12 December 2020

Synthesis, isolation, and characterization of conjugates of ovalbumin with monomethoxypolyethylene glycol using cyanuric chloride as the coupling agent

1 reference

12 December 2020

Preparation of a polyethylene glycol: superoxide dismutase adduct, and an examination of its blood circulation life and anti-inflammatory activity

1 reference

12 December 2020

Degradation of side-chains of N-(2-hydroxypropyl)methacrylamide copolymers by lysosomal thiol-proteinases

1 reference

12 December 2020

Reduced bone marrow toxicity of neocarzinostatin by conjugation with divinyl ether-maleic acid copolymer

1 reference

12 December 2020

Tolerogenic polyethylene glycol derivatives of xenogeneic monoclonal immunoglobulins

1 reference

12 December 2020

High efficacy of monomethoxypolyethylene glycolconjugated l-asparaginase (PEG2-ASP) in two patients with hematological malignancies

1 reference

12 December 2020

Pharmacokinetics of recombinant human granulocyte colony-stimulating factor conjugated to polyethylene glycol in rats

1 reference

12 December 2020

Chemical modification of superoxide dismutase. Extension of plasma half life of the enzyme through its reversible binding to the circulating albumin

1 reference

12 December 2020

Preparation of polyethylene glycol-tissue plasminogen activator adducts that retain functional activity: characteristics and behavior in three animal species

1 reference

12 December 2020

Preparation of a non-immunogenic arginase by the covalent attachment of polyethylene glycol

1 reference

12 December 2020

Hypouricaemic effect of polyethyleneglycol modified urate oxidase

1 reference

12 December 2020

Use of polyethylene glycol-modified uricase (PEG-uricase) to treat hyperuricemia in a patient with non-Hodgkin lymphoma

1 reference

12 December 2020

Receptor-mediated gene delivery and expression in vivo.

1 reference

12 December 2020

Chemical engineering of the monoclonal antibody A7 by polyethylene glycol for targeting cancer chemotherapy

1 reference

12 December 2020

Properties of two urate oxidases modified by the covalent attachment of poly(ethylene glycol)

1 reference

12 December 2020

Some properties of polyethylene glycol:phenylalanine ammonia-lyase adducts

1 reference

12 December 2020

The pharmacokinetics of polymer-bound adriamycin

1 reference

12 December 2020

The uses and properties of PEG-linked proteins

1 reference

12 December 2020

Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo.

1 reference

12 December 2020

Chemical modification of recombinant interleukin 2 by polyethylene glycol increases its potency in the murine Meth A sarcoma model

1 reference

12 December 2020

Clinical pharmacology of polyethylene glycol-L-asparaginase

1 reference

12 December 2020

Lipase modified for solubility in organic solvents

1 reference

12 December 2020

Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase

1 reference

12 December 2020

Preparation, properties and antileukemic activity of arabinosylcytosine polysaccharide conjugates

1 reference

12 December 2020

Pharmacological and therapeutic properties of carrier bound methotrexate against tumor confined to a third space body compartment

1 reference

12 December 2020

Chemical modification of alpha-thrombin and in vitro characterization of its anticoagulant activity

1 reference

12 December 2020

Antitumor activity of monomeric and polymeric cyclophosphamide derivatives compared with in vitro hydrolysis

1 reference

12 December 2020

SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy

1 reference

12 December 2020

Reduction of immunogenicity by covalent modification of murine and rabbit immunoglobulins with oxidized dextrans of low molecular weight

1 reference

12 December 2020

Clinical experiences with polyethylene glycol-bound E. coli L-asparaginase in patients with multiple recurrences of acute lymphoblastic leukemia

1 reference

12 December 2020

Fate of N-(2-hydroxypropyl)methacrylamide copolymers with pendent galactosamine residues after intravenous administration to rats

1 reference

12 December 2020

The development of anti-interleukin-2 antibodies in patients treated with recombinant human interleukin-2 (IL-2)

1 reference

12 December 2020

Use of oily contrast medium for selective drug targeting to tumor: enhanced therapeutic effect and X-ray image

1 reference

12 December 2020

Modification of amino groups in porcine pancreatic elastase with polyethylene glycol in relation to binding ability towards anti-serum and to enzymic activity

1 reference

12 December 2020

[Soluble high molecular weight derivatives of pancreatic trypsin inhibitor. Modification of pancreatic trypsin inhibitor by soluble polysaccharides activated by titanium tetrachloride]

1 reference

12 December 2020

Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran. I: Synthesis and characterization

1 reference

12 December 2020

Passive tumor targeting of soluble macromolecules and drug conjugates

1 reference

12 December 2020

Polymeric drug-carriers containing doxorubicin and melanocyte-stimulating hormone: in vitro and in vivo evaluation against murine melanoma

1 reference

12 December 2020

Effects of monomethoxypoly(ethylene glycol) modification of ribonuclease on antibody recognition, substrate accessibility and conformational stability

1 reference

12 December 2020

Targeting of N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugate to the hepatocyte galactose-receptor in mice: visualisation and quantification by gamma scintigraphy as a basis for clinical targeting studies

1 reference

12 December 2020

A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone

1 reference

12 December 2020

Schedule dependency of the antitumor activity and toxicity of polyethylene glycol-modified interleukin 2 in murine tumor models.

1 reference

12 December 2020

Stabilization of Human beta-D-N-Acetylhexosaminidase A towards Proteolytic Inactivation by Coupling It to Poly(N-vinylpyrrolidone)

1 reference

12 December 2020

Enzyme therapy: II. Effect of covalent attachment of polyethylene glycol on biochemical parameters and immunological determinants of beta-glucosidase and alpha-galactosidase

1 reference

12 December 2020

Studies on the effect of PEG-modified urokinase on coagulation-fibrinolysis using beagles

1 reference

12 December 2020

Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats.

1 reference

12 December 2020

N-(2-Hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor: pharmacokinetics in DBA2 mice

1 reference

12 December 2020

Adenosine deaminase deficiency with late onset of recurrent infections: response to treatment with polyethylene glycol-modified adenosine deaminase

1 reference

12 December 2020

Modification of E. coli L-asparaginase with polyethylene glycol: Disappearance of binding ability to anti-asparaginase serum

1 reference

12 December 2020

Conjugation of poly(styrene-co-maleic acid) derivatives to the antitumor protein neocarzinostatin: pronounced improvements in pharmacological properties

1 reference

12 December 2020

Tumoritropic and lymphotropic principles of macromolecular drugs

1 reference

12 December 2020

Antibody responses to honey-bee venom and monomethoxy-polyethylene glycol-modified honey-bee venom in mice

1 reference

12 December 2020

Reduction of plasma urate levels in the cockerel with polyethylene glycol-uricase

1 reference

12 December 2020

Pharmacokinetic properties of polyethylene glycol derivatized superoxide dismutase

1 reference

12 December 2020

Suppression of reaginic antibodies with modified allergens. III. Preparation of tolerogenic conjugates of common allergens with monomethoxypolyethylene glycols of different molecular weights by the mixed anhydride method

1 reference

12 December 2020

Comparison of antitumor effects of daunorubicin covalently linked to poly-L-amino acid carriers

1 reference

12 December 2020

Changes in the toxicity and therapeutic efficacy of daunorubicin linked with a biodegradable carrier

1 reference

12 December 2020

Cell separation by immunoaffinity partitioning with polyethylene glycol-modified protein a in aqueous polymer two-phase systems

1 reference

12 December 2020

A new procedure for the synthesis of polyethylene glycol-protein adducts; Effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin, and α2-macroglobulin

1 reference

12 December 2020

A nonantigenic covalent streptokinase-polyethylene glycol complex with plasminogen activator function

1 reference

12 December 2020

Application of polyvinylpyrrolidone as a carrier for kallikrein

1 reference

12 December 2020

Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes

1 reference

12 December 2020

Higher Antitumor Efficacy of Daunomycin When Linked to Dextran: In Vivo and In Vitro Studies 2

1 reference

12 December 2020

Use of site-directed mutagenesis to enhance the epitope-shielding effect of covalent modification of proteins with polyethylene glycol

1 reference

12 December 2020

Reduced cardiotoxicity of doxorubicin given in the form of N-(2-hydroxypropyl)methacrylamide conjugates: and experimental study in the rat

1 reference

12 December 2020

A phase I study including pharmacokinetics of polyethylene glycol conjugated interleukin-2.

1 reference

12 December 2020

Activity of N-(2-hydroxypropyl)methacrylamide copolymers containing daunomycin against a rat tumour model

1 reference

12 December 2020

10.2165/00003088-199427040-00004

Identifiers

DOI

1 reference

PubMed ID

7834965

Dimensions Publication ID

21 September 2017

0 references

1 reference

PubMed ID

7834965