Perspectives in the field of drug metabolism (Q40632141)

22 September 2017

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title

Perspectives in the field of drug metabolism (English)

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22 September 2017

Garattini S

1

1 reference

PubMed ID

7924903

22 September 2017

language of work or name

English

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publication date

1 January 1994

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22 September 2017

Drug Metabolism Reviews

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22 September 2017

26

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22 September 2017

3

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22 September 2017

537-573

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From fenfluramine racemate to d-fenfluramine. Specificity and potency of the effects on the serotoninergic system and food intake

22 September 2017

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Evidence of the existence of two different intraneuronal pools from which pharmacological agents can release serotonin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Anorectic activity of fluoxetine and norfluoxetine in rats: relationship between brain concentrations and in-vitro potencies on monoaminergic mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Effects of Lilly 110140, a specific inhibitor of 5-hydroxytryptamine uptake, on food intake and on 5-hydroxytryptophan-induced anorexia. Evidence for serotoninergic inhibition of feeding

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Anorectic activity of fluoxetine and norfluoxetine in mice, rats and guinea-pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Comparative studies on the anorectic activity of d-fenfluramine in mice, rats, and guinea pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Effects of short- and long-term administration of fluoxetine on the monoamine content of rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Amoxapine: a review of its pharmacology and efficacy in depressed states

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Antidepressants. A comparative review of the clinical pharmacology and therapeutic use of the 'newer' versus the 'older' drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Amoxapine: neuroleptic as well as antidepressant?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

21 January 2018

Current antidepressants

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Metabolism and disposition of buspirone

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Different effects of intracerebral and systemic administration of buspirone in the forced swimming test: involvement of a metabolite.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Interferon inducers increase O6-alkylguanine-DNA alkyltransferase in the rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Biologic markers in risk assessment for environmental carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Determination of cis-diamminedichloroplatinum (II) in plasma proteins and hemoglobin of cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Quantitation of cis-diamminedichloroplatinum II (cisplatin)-DNA-intrastrand adducts in testicular and ovarian cancer patients receiving cisplatin chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Anti-peptide antibodies detect oncogene-related proteins in urine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Studies on the in vitro conversion of haloperidol to a potentially neurotoxic pyridinium metabolite

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Identification of a potentially neurotoxic pyridinium metabolite of haloperidol in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Molecular epidemiology and the genetics of environmental cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Hemoglobin adducts of aromatic amines: associations with smoking status and type of tobacco

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Levels of mutagens in the urine of smokers of black and blond tobacco correlate with their risk of bladder cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Protein adducts in the molecular dosimetry of chemical carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

The biochemistry of P-glycoprotein-mediated multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Intracellular doxorubicin concentrations and drug-induced DNA damage in a human colon adenocarcinoma cell line and in a drug-resistant subline.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Doxorubicin resistance in P388 leukemia--evidence for reduced drug influx.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

N-benzyladriamycin-14-valerate versus progressively doxorubicin-resistant murine tumours: cellular pharmacology and characterisation of cross-resistance in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Identification of P-glycoprotein in renal brush border membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Genetic basis of multidrug resistance of tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Endogenous mutagens and the causes of aging and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Multidrug resistant transgenic mice as a novel pharmacologic tool

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Mechanisms of multidrug resistance and implications for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Nitrogen mustard-DNA interaction in melphalan-resistant mammary carcinoma cells with elevated intracellular glutathione and glutathione-S-transferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Intracellular glutathione heterogeneity in L1210 murine leukemia sublines made resistant to DNA-interacting anti-neoplastic agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Overexpression of metallothionein confers resistance to anticancer drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Dietary pesticides (99.99% all natural)

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Chemical and biological properties of indole glucosinolates (glucobrassicins): a review

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Mechanisms of anti-carcinogenesis by indole-3-carbinol: effect on the distribution and metabolism of aflatoxin B1 in rainbow trout.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Structure-activity relationships of dietary indoles: a proposed mechanism of action as modifiers of xenobiotic metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Mechanisms of anti-carcinogenesis by indole-3-carbinol: detailed in vivo DNA binding dose-response studies after dietary administration with aflatoxin B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Quantitative inter-relationships between aflatoxin B1 carcinogen dose, indole-3-carbinol anti-carcinogen dose, target organ DNA adduction and final tumor response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Enhanced pancreatic and skin tumorigenesis in cabbage-fed hamsters and mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Anti-tumor and immunomodulatory activity of intraperitoneal IFN-gamma in ovarian carcinoma patients with minimal residual tumor after chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Altered theophylline pharmacokinetics during acute respiratory viral illness

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Effects of cancer disease on the metabolism of anticancer agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Depression of cytochrome P-450 and alterations of protein metabolism in mice treated with the interferon inducer polyriboinosinic acid X polyribocytidylic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Recombinant tumor necrosis factor depresses cytochrome P450-dependent microsomal drug metabolism in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Effects of interleukin-6 on cytochrome P450-dependent mixed-function oxidases in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Depression of liver drug metabolism and increase in plasma fibrinogen by interleukin 1 and tumor necrosis factor: a comparison with lymphotoxin and interferon

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Interleukin-1 and the Pathogenesis of the Acute-Phase Response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Induction of xanthine oxidase and heme oxygenase and depression of liver drug metabolism by interferon: a study with different recombinant interferons

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Interleukin-1 and tumour necrosis factor induce hepatic haem oxygenase. Feedback regulation by glucocorticoids

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Neutral endopeptidase-24.11 inhibitors: from analgesics to antihypertensives?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Enkephalinase (EC 3.4.24.11) inhibitors: protection of endogenous ANF against inactivation and potential therapeutic applications

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

Biological inactivation of enkephalins and the role of enkephalin-dipeptidyl-carboxypeptidase (“enkephalinase”) as neuropeptidase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539408998317

10.3109/03602539408998317

21 January 2018

Identifiers

DOI

1 reference

22 September 2017

1 reference

PubMed ID

7924903