13C NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and gamma-glutamyl cycle activity in a clonal pancreatic beta-cell line. (Q40637734)

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scientific article published on 4 September 2003

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English	13C NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and gamma-glutamyl cycle activity in a clonal pancreatic beta-cell line.	scientific article published on 4 September 2003

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scholarly article

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7 November 2019

13C NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and gamma-glutamyl cycle activity in a clonal pancreatic beta-cell line (English)

1 reference

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7 November 2019

Lorraine Brennan

1

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7 November 2019

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7 November 2019

Chandralal Hewage

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7 November 2019

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7 November 2019

author name string

M Corless

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7 November 2019

N H McClenaghan

5

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7 November 2019

P Newsholme

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publication date

4 September 2003

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7 November 2019

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7 November 2019

46

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7 November 2019

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7 November 2019

1512-1521

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7 November 2019

https://scigraph.springernature.com/pub.10.1007/s00125-003-1184-7

0 references

L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

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Beta-cell mitochondria in the regulation of insulin secretion: a new culprit in type II diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uptake and metabolism of plasma glutamine by the small intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

D-glucose metabolism in BRIN-BD11 islet cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of [1-(13)C)glucose and [2-(13)C]acetate in the hypoxic rat brain..

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The stimulus-secretion coupling of amino acid-induced insulin release. Influence of a nonmetabolized analog of leucine on the metabolism of glutamine in pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GAD65-mediated glutamate decarboxylation reduces glucose-stimulated insulin secretion in pancreatic beta cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The coupling of metabolic to secretory events in pancreatic islets. The possible role of glutathione reductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uptake of alanine, arginine and leucine by mammalian pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unregulated elevation of glutamate dehydrogenase activity induces glutamine-stimulated insulin secretion: identification and characterization of a GLUD1 gene mutation and insulin secretion studies with MIN6 cells overexpressing the mutant glutamate

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of gamma-glutamylcysteine synthetase by L-methionine-S-sulfoximine

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate production in islets of Langerhans: properties of phosphate-activated glutaminase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thiol-mediated redox regulation of neutrophil apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of caspase 3 in HL-60 cells exposed to hydrogen peroxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose regulates leucine-induced insulin release and the expression of the branched chain ketoacid dehydrogenase E1 alpha subunit gene in pancreatic islets.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of gamma-glutamyl transpeptidase in glutamine metabolism by cultured human kidney cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione depletion-induced neutrophil apoptosis is caspase 3 dependent.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutral amino acid transport in isolated rat pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamine and glutamate--their central role in cell metabolism and function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide-mediated mitochondrial damage: a potential neuroprotective role for glutathione

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of glutaminase activity and glutamine metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperinsulinism/hyperammonemia syndrome in children with regulatory mutations in the inhibitory guanosine triphosphate-binding domain of glutamate dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Engineering cultured insulin-secreting pancreatic B-cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line: metabolism of L-alanine is important to the regulation of insulin secreti

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NH2-terminally modified gastric inhibitory polypeptide exhibits amino-peptidase resistance and enhanced antihyperglycemic activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction in islet hormone release: interaction of nitric oxide with basal and nutrient-induced hormone responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATP-sensitive potassium channels and efaroxan-induced insulin release in the electrofusion-derived BRIN-BD11 beta-cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The stimulus-secretion coupling of amino acid-induced insulin release. Metabolic response of pancreatic islets of L-glutamine and L-leucine

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet glutathione and insulin release

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complementary action of antioxidant enzymes in the protection of bioengineered insulin-producing RINm5F cells against the toxicity of reactive oxygen species

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate primes the pump

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose-mediated Ca(2+) signalling in single clonal insulin-secreting cells: evidence for a mixed model of cellular activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of amino acid-induced insulin secretion from the glucose-responsive BRIN-BD11 pancreatic B-cell line.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymic activities in two populations of purified rat islet beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 expression causes redistribution of glutathione to the nucleus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A 13C-n.m.r. investigation of the ionizations within an inhibitor--alpha-chymotrypsin complex. Evidence that both alpha-chymotrypsin and trypsin stabilize a hemiketal oxyanion by similar mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein measurement with the Folin phenol reagent

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular basis and characterization of the hyperinsulinism/hyperammonemia syndrome: predominance of mutations in exons 11 and 12 of the glutamate dehydrogenase gene. HI/HA Contributing Investigators

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection against the co-operative toxicity of nitric oxide and oxygen free radicals by overexpression of antioxidant enzymes in bioengineered insulin-producing RINm5F cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose regulation of glutaminolysis and its role in insulin secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate is not a messenger in insulin secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

γ-glutamyltranspeptidase activity in pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Attenuation of expression of gamma-glutamylcysteine synthetase by ribozyme transfection enhance insulin secretion by pancreatic beta cell line, MIN6.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12955201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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