Molecular mechanisms of antiestrogen action in breast cancer (Q40644017)

22 September 2017

1 reference

title

Molecular mechanisms of antiestrogen action in breast cancer (English)

1 reference

22 September 2017

1

V C Jordan

1 reference

PubMed ID

7981455

22 September 2017

language of work or name

English

0 references

publication date

1 January 1994

1 reference

Breast Cancer Research and Treatment

22 September 2017

1 reference

22 September 2017

31

1 reference

22 September 2017

1

1 reference

22 September 2017

41-52

1 reference

https://scigraph.springernature.com/pub.10.1007/bf00689675

22 September 2017

0 references

cites work

A therapeutic withdrawal can make a strategic advance

1 reference

12 December 2020

In vivo inhibition of insulin-like growth factor I gene expression by tamoxifen

1 reference

12 December 2020

The pharmacology and clinical uses of tamoxifen

1 reference

12 December 2020

What do we know and what don't we know about tamoxifen in the human uterus

1 reference

12 December 2020

An estrogen receptor positive MCF-7 clone that is resistant to antiestrogens and estradiol

1 reference

12 December 2020

Characterization of a receptor-negative, hormone-nonresponsive clone derived from a T47D human breast cancer cell line kept under estrogen-free conditions

1 reference

12 December 2020

Studies on the mechanism of action of the nonsteroidal antioestrogen tamoxifen (I.C.I. 46,474) in the rat.

1 reference

12 December 2020

Studies of tamoxifen as a promoter of hepatocarcinogenesis in female Fischer F344 rats

1 reference

12 December 2020

Point mutation of estrogen receptor (ER) in the ligand-binding domain changes the pharmacology of antiestrogens in ER-negative breast cancer cells stably expressing complementary DNAs for ER.

1 reference

12 December 2020

Resistance to tamoxifen with persisting sensitivity to estrogen: possible mediation by excessive antiestrogen binding site activity

1 reference

12 December 2020

Effects of tamoxifen adjuvant therapy and a low-fat diet on serum binding proteins and estradiol bioavailability in postmenopausal breast cancer patients

1 reference

12 December 2020

Variant human breast tumor estrogen receptor with constitutive transcriptional activity

1 reference

12 December 2020

Estrogen-like effects of tamoxifen on human endometrial carcinoma transplanted into nude mice

1 reference

12 December 2020

Investigation of the mechanism of tamoxifen-stimulated breast tumor growth with nonisomerizable analogues of tamoxifen and metabolites.

1 reference

12 December 2020

Anti-steroidal and anti-growth factor activities of anti-estrogens

1 reference

12 December 2020

An estrogen receptor model to describe the regulation of prolactin synthesis by antiestrogens in vitro

1 reference

12 December 2020

Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells

1 reference

12 December 2020

Effects of tamoxifen therapy on lipid and lipoprotein levels in postmenopausal patients with node-negative breast cancer.

1 reference

12 December 2020

Estrogen-stimulated prolactin synthesis in vitro. Classification of agonist, partial agonist, and antagonist actions based on structure

1 reference

12 December 2020

Characterization of the estrogen receptor in two antiestrogen-resistant cell lines, LY2 and T47D.

1 reference

12 December 2020

Nonsteroidal antiestrogens: Their biological effects and potential mechanisms of action

1 reference

12 December 2020

Effect of steroidal and nonsteroidal antiestrogens on the growth of a tamoxifen-stimulated human endometrial carcinoma (EnCa101) in athymic mice

1 reference

12 December 2020

The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor

1 reference

12 December 2020

Differences between estrogen- and antiestrogen-estrogen receptor complexes from human breast tumors identified with an antibody raised against the estrogen receptor.

1 reference

12 December 2020

Evidence for the metabolic activation of non-steroidal antioestrogens: a study of structure-activity relationships

1 reference

12 December 2020

Evaluation of the antitumour activity of the non-steroidal antioestrogen monohydroxytamoxifen in the DMBA-induced rat mammary carcinoma model

1 reference

12 December 2020

Identification of estrogenic tamoxifen metabolite(s) in tamoxifen-resistant human breast tumors

1 reference

12 December 2020

Growth regulation of estrogen receptor-negative breast cancer cells transfected with complementary DNAs for estrogen receptor

1 reference

12 December 2020

The binding of [3H]-oestradiol-17 beta in the immature rat uterus during the sequential administration of non-steroidal anti-oestrogens

1 reference

12 December 2020

Tamoxifen (ICI 46,474) and the human carcinoma 8S oestrogen receptor

1 reference

12 December 2020

Toremifene, a new antiestrogenic compound, for treatment of advanced breast cancer. Phase II study

1 reference

12 December 2020

Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration

1 reference

12 December 2020

Anti-oestrogens induce the secretion of active transforming growth factor beta from human fetal fibroblasts

1 reference

12 December 2020

Prevention of breast cancer with tamoxifen--an update on the Royal Marsden Hospital pilot programme

1 reference

12 December 2020

Estrogen control of prolactin synthesis in vitro

1 reference

12 December 2020

Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors

1 reference

12 December 2020

Steroidal pure antioestrogens

1 reference

12 December 2020

A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity

1 reference

12 December 2020

Transforming growth factor beta: potential autocrine growth inhibitor of estrogen receptor-negative human breast cancer cells

1 reference

12 December 2020

Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy. 133 randomised trials involving 31,000 recurrences and 24,000 deaths among 75,000 women. Early Breast Cancer Trialists' Collaborative Group

1 reference

12 December 2020

Estrogenic activity of phenol red

1 reference

12 December 2020

Antiestrogen ICI 164,384 reduces cellular estrogen receptor content by increasing its turnover

1 reference

12 December 2020

Direct and reversible inhibition of estradiol-stimulated prolactin synthesis by antiestrogens in vitro

1 reference

12 December 2020

Effect of tamoxifen on serum insulinlike growth factor I levels in stage I breast cancer patients

1 reference

12 December 2020

Droloxifene, a new anti-oestrogen in postmenopausal advanced breast cancer: preliminary results of a double-blind dose-finding phase II trial

1 reference

12 December 2020

Binding of antiestrogens exposes an occult antigenic determinant in the human estrogen receptor

1 reference

12 December 2020

The human oestrogen receptor functions in yeast

1 reference

12 December 2020

Evidence that transforming growth factor-beta is a hormonally regulated negative growth factor in human breast cancer cells

1 reference

12 December 2020

Role of estrogens as promoters of hepatic neoplasia

1 reference

12 December 2020

Structural requirements for the pharmacological activity of nonsteroidal antiestrogens in vitro.

1 reference

12 December 2020

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

1 reference

12 December 2020

Cellular and molecular mechanism of action of antiestrogens.

1 reference

12 December 2020

Ligand interaction at the estrogen receptor to program antiestrogen action: a study with nonsteroidal compounds in vitro.

1 reference

12 December 2020

High-affinity anti-oestrogen binding site distinct from the oestrogen receptor

1 reference

12 December 2020

Endocrine pharmacology of antiestrogens as antitumor agents

1 reference

12 December 2020

Oestrogen-responsive human breast cancer in long term tissue culture

1 reference

12 December 2020

Structure-function relationships of hydroxylated metabolites of tamoxifen that control the proliferation of estrogen-responsive T47D breast cancer cells in vitro.

1 reference

12 December 2020

Effects of tamoxifen on cardiovascular risk factors in postmenopausal women

1 reference

12 December 2020

Expression of transforming growth factor alpha and its messenger ribonucleic acid in human breast cancer: its regulation by estrogen and its possible functional significance

1 reference

12 December 2020

Inhibition of tamoxifen-stimulated growth of an MCF-7 tumor variant in athymic mice by novel steroidal antiestrogens.

1 reference

12 December 2020

Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of bcar-1, a common integration site

1 reference

12 December 2020

The mechanism of ICI 164,384 antiestrogenicity involves rapid loss of estrogen receptor in uterine tissue

1 reference

12 December 2020

Effect of antibodies to estrogen receptor on the binding of 3H-labeled antiestrogens and androstanediol in the uterus

1 reference

12 December 2020

The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat.

1 reference

12 December 2020

Alteration of endocrine parameters in premenopausal women with breast cancer during long-term adjuvant therapy with tamoxifen as the single agent

1 reference

12 December 2020

Role and mechanism of action of tamoxifen in premenopausal women with metastatic breast carcinoma

1 reference

12 December 2020

Bis(4-hydroxyphenyl)[2-(phenoxysulfonyl)phenyl]methane: isolation and structure elucidation of a novel estrogen from commercial preparations of phenol red (phenolsulfonphthalein)

1 reference

12 December 2020

A randomized clinical trial evaluating tamoxifen in the treatment of patients with node-negative breast cancer who have estrogen-receptor-positive tumors

1 reference

12 December 2020

Epidemiologic data on exogenous hormones and hepatocellular carcinoma and selected other cancers

1 reference

12 December 2020

The evolution of paradigms for the management of breast cancer: a personal perspective

1 reference

12 December 2020

Structural differences between the hormone and antihormone estrogen receptor complexes bound to the hormone response element

1 reference

12 December 2020

A model to describe how a point mutation of the estrogen receptor alters the structure-function relationship of antiestrogens

1 reference

12 December 2020

Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer

1 reference

12 December 2020

Variant estrogen receptor mRNA species detected in human breast cancer biopsy samples.

1 reference

12 December 2020

Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture

1 reference

12 December 2020

Antiestrogen Action in the Uterus: Biological Ineffectiveness of Nuclear Bound Estradiol after Antiestrogen123

1 reference

12 December 2020

The estrogen receptor from a tamoxifen stimulated MCF-7 tumor variant contains a point mutation in the ligand binding domain

1 reference

12 December 2020

Induction of covalent DNA adducts in rodents by tamoxifen.

1 reference

12 December 2020

Inhibition of estrogen receptor-DNA binding by the "pure" antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization

1 reference

12 December 2020

Antiestrogenic action of toremifene on hormone-dependent, -independent, and heterogeneous breast tumor growth in the athymic mouse

1 reference

12 December 2020

Long-term adjuvant tamoxifen therapy for breast cancer

1 reference

12 December 2020

Acquired tamoxifen resistance: correlation with reduced breast tumor levels of tamoxifen and isomerization of trans-4-hydroxytamoxifen.

1 reference

12 December 2020

The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties

1 reference

12 December 2020

Regulation of the levels of three transforming growth factor beta mRNAs by estrogen and their effects on the proliferation of human breast cancer cells

1 reference

12 December 2020

Human breast cancer in the athymic nude mouse: cytostatic effects of long-term antiestrogen therapy

1 reference

12 December 2020

Inhibition of angiogenesis by antiestrogens

1 reference

12 December 2020

Tumor promotion as a target for estrogen/antiestrogen effects in rat hepatocarcinogenesis

1 reference

12 December 2020

Timing of Breast Cancer Excision during the Menstrual Cycle Influences Duration of Disease-free Survival

1 reference

12 December 2020

A potent specific pure antiestrogen with clinical potential

1 reference

12 December 2020

Induction of transforming growth factor beta 1 in human breast cancer in vivo following tamoxifen treatment

1 reference

12 December 2020

Fourteenth Gaddum Memorial Lecture. A current view of tamoxifen for the treatment and prevention of breast cancer

1 reference

12 December 2020

Biochemical pharmacology of antiestrogen action

1 reference

12 December 2020

Tamoxifen and metabolites in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth.

1 reference

12 December 2020

Enhanced growth of an estrogen receptor-negative endometrial adenocarcinoma by estradiol in athymic mice

1 reference

12 December 2020

Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers

1 reference

12 December 2020

Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues.

1 reference

12 December 2020

Down-regulation of transforming growth factor-alpha by tamoxifen in human breast cancer

1 reference

12 December 2020

Tamoxifen in premenopausal patients with metastatic breast cancer: a review

1 reference

12 December 2020

A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF00689675

1 reference

PubMed ID

7981455

Dimensions Publication ID

22 September 2017

0 references

1 reference

PubMed ID

7981455