Potential use of Sox9 gene therapy for intervertebral degenerative disc disease (Q40654974)

22 September 2017

Potential use of Sox9 gene therapy for intervertebral degenerative disc disease (English)

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22 September 2017

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Ronjon Paul

1

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22 September 2017

Rex C Haydon

2

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22 September 2017

Hongwei Cheng

3

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22 September 2017

Akira Ishikawa

4

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22 September 2017

Nikola Nenadovich

5

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22 September 2017

Wei Jiang

6

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22 September 2017

Lan Zhou

7

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22 September 2017

Benjamin Breyer

8

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22 September 2017

Tao Feng

9

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22 September 2017

Purnendu Gupta

10

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22 September 2017

Tong-Chuan He

11

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22 September 2017

Frank M Phillips

12

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22 September 2017

language of work or name

English

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publication date

1 April 2003

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22 September 2017

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22 September 2017

28

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22 September 2017

8

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22 September 2017

755-763

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Gene therapy and spinal disorders

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

Molecular biology of degenerative disc disease

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

Transcriptional mechanisms of chondrocyte differentiation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: an in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding gene

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

Sox9 is required for cartilage formation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

From head to toes: the multiple facets of Sox proteins

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

Toward understanding SOX9 function in chondrocyte differentiation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

SOX9 directly regulates the type-II collagen gene

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

Aging and degeneration of the human intervertebral disc.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

Early onset of disk degeneration and spondylosis in sand rats (Psammomys obesus).

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

Human intervertebral disc: structure and function

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

An overview of the incidences and costs of low back pain

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

The cost of 1989 workers' compensation low back pain claims

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

Anti-apoptotic effects of IGF-1 and PDGF on human intervertebral disc cells in vitro

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-alpha

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

Recurrent low back pain and early disc degeneration in the young

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

Structural and functional characterization of the mouse Sox9 promoter: implications for campomelic dysplasia

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

Degeneration and the chemical composition of the human lumbar intervertebral disc

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

Analysis of aging and degeneration of the human intervertebral disc. Comparison of surgical specimens with normal controls.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

Collagen gene expression and mechanical properties of intervertebral disc cell-alginate cultures

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

Parallel expression of Sox9 and Col2a1 in cells undergoing chondrogenesis

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4123440

Adenovirus-mediated gene transfer to nucleus pulposus cells. Implications for the treatment of intervertebral disc degeneration

19 August 2018

1 reference

12 December 2020

Histological changes in aging lumbar intervertebral discs. Their role in protrusions and prolapses

1 reference

12 December 2020

Low back pain in relation to lumbar disc degeneration

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12 December 2020

The effect of compressive force applied to the intervertebral disc in vivo. A study of proteoglycans and collagen

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12 December 2020

Biochemical changes in intervertebral disc degeneration

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12 December 2020

Collagens in the injured porcine intervertebral disc

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12 December 2020

Ultrastructure of the human intervertebral disc. I. Changes in notochordal cells with age

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12 December 2020

Epidemiology, etiology, diagnostic evaluation, and treatment of low back pain

1 reference

12 December 2020

Type-II collagen gene expression is transiently upregulated in experimentally induced degeneration of rabbit intervertebral disc

1 reference

12 December 2020

A longitudinal study of the matrix changes induced in the intervertebral disc by surgical damage to the annulus fibrosus

1 reference

12 December 2020

Age-dependent correlation of low-back pain and lumbar disc regeneration

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12 December 2020

Phenotypic Characteristics of Rabbit Intervertebral Disc Cells

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12 December 2020

Experimental intervertebral disc degeneration: morphologic and proteoglycan changes over time

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12 December 2020

Collagen synthesis and types I, III, IV, and VI collagens in an animal model of disc degeneration

1 reference

12 December 2020

Degeneration of the intervertebral disks and spondylosis in aging sand rats

1 reference

12 December 2020

Structural and functional implications of age-related abnormal modifications in collagen II from intervertebral disc

1 reference

12 December 2020

10.1097/00007632-200304150-00006

Identifiers

DOI

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22 September 2017

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22 September 2017

PubMed publication ID

12698117

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