Substituted benzo[i]phenanthridines as mammalian topoisomerase-targeting agents (Q40661192)

22 September 2017

title

Substituted benzo[i]phenanthridines as mammalian topoisomerase-targeting agents (English)

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22 September 2017

Darshan Makhey

1

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22 September 2017

Dajie Li

2

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22 September 2017

Baoping Zhao

3

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22 September 2017

Sai Peng Sim

4

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22 September 2017

Tsai Kun Li

5

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22 September 2017

Angela Liu

6

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22 September 2017

Leroy F Liu

7

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22 September 2017

Edmond J LaVoie

8

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22 September 2017

language of work or name

English

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publication date

1 April 2003

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Bioorganic & Medicinal Chemistry

22 September 2017

published in

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22 September 2017

volume

11

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22 September 2017

issue

8

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22 September 2017

page(s)

1809-1820

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https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900053-1

22 September 2017

1 reference

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DNA topoisomerase poisons as antitumor drugs

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DNA topoisomerases: essential enzymes and lethal targets

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Tumor cell death induced by topoisomerase-targeting drugs.

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Supercoiling of the DNA template during transcription

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Transcription-driven supercoiling of DNA: direct biochemical evidence from in vitro studies

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Structure activity of topoisomerase i poisons related to hoechst 33342

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Synthesis and Evaluation of Terbenzimidazoles as Topoisomerase I Inhibitors

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Substituted 2,5'-Bi-1H-benzimidazoles: topoisomerase I inhibition and cytotoxicity

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7 January 2021

Synthesis and biological activity of some antitumor benzophenanthridinium salts

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7 January 2021

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Synthesis and antitumor activity of structural analogues of the anticancer benzophenanthridine alkaloid fagaronine chloride

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Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives

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Induction of mammalian DNA topoisomerase I and II mediated DNA cleavage by saintopin, a new antitumor agent from fungus

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Synthesis of New Indeno[1,2-c]isoquinolines: Cytotoxic Non-Camptothecin Topoisomerase I Inhibitors

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Synthesis of new dihydroindeno[1,2-c]isoquinoline and indenoisoquinolinium chloride topoisomerase I inhibitors having high in vivo anticancer activity in the hollow fiber animal model

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Bis(phenazine-1-carboxamides): structure-activity relationships for a new class of dual topoisomerase I/II-directed anticancer drugs

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Novel angular benzophenazines: dual topoisomerase I and topoisomerase II inhibitors as potential anticancer agents

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Inhibition of topoisomerase I function by coralyne and 5,6-dihydrocoralyne

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Inhibition of topoisomerase I function by nitidine and fagaronine

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Potential anticancer agents XXXI. N-demethylation of fagaronine

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Interaction of the antileukemic alkaloid, 2-hydroxy-3,8,9-trimethoxy-5-methylbenzo[c]phenanthridine (fagaronine), with nucleic acids

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Plant antitumor agents, 27. Isolation, structure, and structure activity relationships of alkaloids from Fagara macrophylla

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Synthesis and evaluation of new 6-amino- substituted benzo[c]phenanthridine derivatives

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Experimental antileukemic agents. Coralyne, analogs, and related compounds

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Tetramethoxydibenzoquinolizinium salts. Preparation and antileukemic activity of some positional and structural isomers of coralyne

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7 January 2021

Substituted benz[a]acridines and benz[c]acridines as mammalian topoisomerase poisons

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Nitroarylstannanes as synthons for the preparation of phenanthridine and benzo[i]phenanthridine derivatives

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New methods and reagents in organic synthesis. 8. Trimethylsilyldiazomethane. A new, stable, and safe reagent for the classical arndt-eistert synthesis

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Selective cytotoxicity of topoisomerase-directed protoberberines against glioblastoma cells

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Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy

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Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability

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Drug resistance mechanisms of topoisomerase I drugs.

1 reference

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7 January 2021

10.1016/S0968-0896(03)00053-1

Identifiers

DOI

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22 September 2017

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