Role of DNA polymerase eta in the UV mutation spectrum in human cells (Q40663020)

22 September 2017

Role of DNA polymerase eta in the UV mutation spectrum in human cells (English)

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22 September 2017

Anne Stary

1

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22 September 2017

Patricia Kannouche

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2

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22 September 2017

Alan R Lehmann

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3

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22 September 2017

Alain Sarasin

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4

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22 September 2017

language of work or name

English

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publication date

18 March 2003

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Journal of Biological Chemistry

22 September 2017

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22 September 2017

278

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22 September 2017

21

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22 September 2017

18767-18775

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Sunlight and the onset of skin cancer

22 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

The molecular pathways of ultraviolet-induced carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Distribution and repair of photolesions in DNA: genetic consequences and the role of sequence context

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

UV damage and repair mechanisms in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Individual determination of the yield of the main UV-induced dimeric pyrimidine photoproducts in DNA suggests a high mutagenicity of CC photolesions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Molecular mechanism of nucleotide excision repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Mutagenicity of a unique thymine-thymine dimer or thymine-thymine pyrimidine pyrimidone (6-4) photoproduct in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Mutagenesis induced by single UV photoproducts in E. coli and yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

The (6-4) photoproduct of thymine-thymine induces targeted substitution mutations in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Cyclobutane pyrimidine dimers are responsible for the vast majority of mutations induced by UVB irradiation in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Specialized DNA polymerases, cellular survival, and the genesis of mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Replication of UV-damaged DNA: new insights into links between DNA polymerases, mutagenesis and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Translesion synthesis by the UmuC family of DNA polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

A plethora of lesion-replicating DNA polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Error-prone repair DNA polymerases in prokaryotes and eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Managing DNA polymerases: coordinating DNA replication, DNA repair, and DNA recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Developmental control of cell cycle regulators: a fly's perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Low fidelity DNA synthesis by human DNA polymerase-eta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

The Y-family of DNA polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Mechanisms of accurate translesion synthesis by human DNA polymerase eta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

hRAD30 mutations in the variant form of xeroderma pigmentosum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Abnormal, error-prone bypass of photoproducts by xeroderma pigmentosum variant cell extracts results in extreme strand bias for the kinds of mutations induced by UV light

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Xeroderma pigmentosum variant cells are less likely than normal cells to incorporate dAMP opposite photoproducts during replication of UV-irradiated plasmids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Evidence from mutation spectra that the UV hypermutability of xeroderma pigmentosum variant cells reflects abnormal, error-prone replication on a template containing photoproducts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Ultraviolet hypermutability of a shuttle vector propagated in xeroderma pigmentosum variant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Replication fork bypass of a pyrimidine dimer blocking leading strand DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Bypass of a site-specific cis-Syn thymine dimer in an SV40 vector during in vitro replication by HeLa and XPV cell-free extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

A single (6-4) photoproduct inhibits plasmid DNA replication in xeroderma pigmentosum variant cell extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Impaired translesion synthesis in xeroderma pigmentosum variant extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

DNA polymerase eta undergoes alternative splicing, protects against UV sensitivity and apoptosis, and suppresses Mre11-dependent recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Complementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase eta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Characteristics of UV-induced mutation spectra in human XP-D/ERCC2 gene-mutated xeroderma pigmentosum and trichothiodystrophy cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Description of a new amplifiable shuttle vector for mutagenesis studies in human cells: application to N-methyl-N'-nitro-N-nitrosoguanidine-induced mutation spectrum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Simian virus 40 (SV40) large T antigen-dependent amplification of an Epstein-Barr virus-SV40 hybrid shuttle vector integrated into the human HeLa cell genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Statistical test for the comparison of samples from mutational spectra

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase iota

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Role of RecA protein in untargeted UV mutagenesis of bacteriophage lambda: evidence for the requirement for the dinB gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein dinB

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Requirement of DNA polymerase eta for error-free bypass of UV-induced CC and TC photoproducts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

TP53 mutations in human skin cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Biochemical characterization of human DNA polymeraseiprovides clues to its biological function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Frequency of ultraviolet light-induced mutations is higher in xeroderma pigmentosum variant cells than in normal human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Error-Prone DNA Polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Fidelity of human DNA polymerase eta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

Genotoxic evaluation of three heterocyclic N-methylcarbamate pesticides using the mouse bone marrow micronucleus assay and the Saccharomyces cerevisiae strains D7 and D61.M.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211838200

21 January 2018

Identifiers

DOI

10.1074/JBC.M211838200

1 reference

22 September 2017

1 reference