The human B-cell lymphoma cell line RC-K8 has multiple genetic alterations that dysregulate the Rel/NF-kappaB signal transduction pathway (Q40683317)

22 September 2017

title

The human B-cell lymphoma cell line RC-K8 has multiple genetic alterations that dysregulate the Rel/NF-kappaB signal transduction pathway (English)

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22 September 2017

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3

Andreas Rosenwald

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22 September 2017

author name string

Demetrios Kalaitzidis

1

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22 September 2017

R Eric Davis

2

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22 September 2017

Louis M Staudt

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22 September 2017

Thomas D Gilmore

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22 September 2017

language of work or name

English

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publication date

1 December 2002

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22 September 2017

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22 September 2017

volume

21

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22 September 2017

issue

57

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22 September 2017

page(s)

8759-8768

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Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

22 September 2017

cites work

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The lymphochip: a specialized cDNA microarray for the genomic-scale analysis of gene expression in normal and malignant lymphocytes.

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Three mutations in v-Rel render it resistant to cleavage by cell-death protease caspase-3.

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7 January 2021

Phosphorylation of IkappaB-alpha inhibits its cleavage by caspase CPP32 in vitro

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7 January 2021

Molecular-cytogenetic comparison of mucosa-associated marginal zone B-cell lymphoma and large B-cell lymphoma arising in the gastro-intestinal tract

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7 January 2021

Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

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7 January 2021

Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha.

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7 January 2021

NF-kappa B inhibition causes spontaneous apoptosis in Epstein-Barr virus-transformed lymphoblastoid cells

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7 January 2021

Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206033

7 January 2021

Cluster analysis and display of genome-wide expression patterns

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206033

7 January 2021

Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206033

7 January 2021

Missing pieces in the NF-kappaB puzzle

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7 January 2021

The Rel/NF-kappaB signal transduction pathway: introduction

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206033

7 January 2021

Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel

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7 January 2021

Malignant transformation of primary chicken spleen cells by human transcription factor c-Rel

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7 January 2021

Rel/NF-kappa B/I kappa B signal transduction in the generation and treatment of human cancer

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7 January 2021

The Rel subunit of NF-kappaB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations

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7 January 2021

Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity

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7 January 2021

Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2.

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7 January 2021

Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma

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7 January 2021

Genomic organization and expression of the rearranged REL proto-oncogene in the human B-cell lymphoma cell line RC-K8.

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7 January 2021

How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex

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7 January 2021

Characterization of a new human lymphoma cell line (RC-K8) with t(11;14) chromosome abnormality

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7 January 2021

Chromosomal localization of the genes encoding the p50/p105 subunits of NF-kappa B (NFKB2) and the I kappa B/MAD-3 (NFKBI) inhibitor of NF-kappa B to 4q24 and 14q13, respectively

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206033

7 January 2021

IkappaBbeta, but not IkappaBalpha, functions as a classical cytoplasmic inhibitor of NF-kappaB dimers by masking both NF-kappaB nuclear localization sequences in resting cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206033

7 January 2021

Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma.

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7 January 2021

Activators and target genes of Rel/NF-kappaB transcription factors

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7 January 2021

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7 January 2021

E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206033

7 January 2021

vRel is an inactive member of the Rel family of transcriptional activating proteins

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206033

7 January 2021

Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206033

7 January 2021

The molecular and cellular origins of Hodgkin's disease

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206033

7 January 2021

Epstein-Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-kappaB through a pathway that includes the NF-kappaB-inducing kinase and the IkappaB kinases IKKalpha and IKKbeta

1 reference

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1206033

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Dimensions Publication ID

22 September 2017

1035860975

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