Intranasal immunotherapy for the treatment of Alzheimer's disease: Escherichia coli LT and LT(R192G) as mucosal adjuvants (Q40684882)

22 September 2017

Intranasal immunotherapy for the treatment of Alzheimer's disease: Escherichia coli LT and LT(R192G) as mucosal adjuvants (English)

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22 September 2017

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Cynthia A Lemere

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22 September 2017

Edward T Spooner

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22 September 2017

Jodi F Leverone

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22 September 2017

Chica Mori

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22 September 2017

John D Clements

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22 September 2017

1 November 2002

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22 September 2017

Neurobiology of Aging

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22 September 2017

23

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22 September 2017

6

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22 September 2017

991-1000

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Functional diversity of helper T lymphocytes

22 September 2017

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https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy.

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https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Monophosphoryl lipid A (MPL) formulations for the next generation of vaccines

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https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Monophosphoryl lipid A enhances mucosal and systemic immunity to vaccine antigens following intranasal administration

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https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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7 January 2021

Interplay of cytokines and adjuvants in the regulation of mucosal and systemic HIV-specific CTL.

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7 January 2021

Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques

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7 January 2021

Intranasal administration of peptide vaccine protects human/mouse radiation chimera from influenza infection.

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7 January 2021

Induction of antigen-specific T cell responses in human volunteers after intranasal immunization with a whole-cell pertussis vaccine

1 reference

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7 January 2021

Encapsulation in biodegradable microparticles enhances serum antibody response to parenterally-delivered beta-amyloid in mice

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https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

The role of cAMP in mucosal adjuvanticity of Escherichia coli heat-labile enterotoxin (LT)

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https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Antibody-independent protection against rotavirus infection of mice stimulated by intranasal immunization with chimeric VP4 or VP6 protein.

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7 January 2021

Functional mapping of protective domains and epitopes in the rotavirus VP6 protein

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7 January 2021

LT(R192G), a non-toxic mutant of the heat-labile enterotoxin of Escherichia coli, elicits enhanced humoral and cellular immune responses associated with protection against lethal oral challenge with Salmonella spp.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Adjuvant activity of Escherichia coli heat-labile enterotoxin and effect on the induction of oral tolerance in mice to unrelated protein antigens.

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https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Mucosal delivery of vaccines

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7 January 2021

Dissociation of Escherichia coli heat-labile enterotoxin adjuvanticity from ADP-ribosyltransferase activity

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https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Mutants of Escherichia coli heat-labile toxin lacking ADP-ribosyltransferase activity act as nontoxic, mucosal adjuvants

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7 January 2021

Immunization against Alzheimer's beta -amyloid plaques via EFRH phage administration

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7 January 2021

Human papillomavirus virus-like particles are efficient oral immunogens when coadministered with Escherichia coli heat-labile enterotoxin mutant R192G or CpG DNA.

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https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Adjuvant activity of a nontoxic mutant of Escherichia coli heat-labile enterotoxin on systemic and mucosal immune responses elicited against a heterologous antigen carried by a live Salmonella enterica serovar Typhimurium vaccine strain

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Antibody responses in volunteers induced by nasal influenza vaccine combined with Escherichia coli heat-labile enterotoxin B subunit containing a trace amount of the holotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Induction of systemic immune responses to measles virus synthetic peptides administered intranasally

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7 January 2021

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

1 reference

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7 January 2021

Adjuvant activity of the heat-labile enterotoxin from enterotoxigenic Escherichia coli for oral administration of inactivated influenza virus vaccine

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Safety and immunogenicity of oral inactivated whole-cell Helicobacter pylori vaccine with adjuvant among volunteers with or without subclinical infection

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7 January 2021

The role of nasopharyngeal lymphoid tissue

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7 January 2021

Systemic and mucosal immunity induced by BCG vector expressing outer-surface protein A of Borrelia burgdorferi

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Vaccination against Helicobacter pylori in non-human primate models and humans

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7 January 2021

Oral immunization with recombinant Helicobacter pylori urease induces secretory IgA antibodies and protects mice from challenge with Helicobacter felis

1 reference

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7 January 2021

Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

The adjuvant effect of Vibrio cholerae and Escherichia coli heat-labile enterotoxins is linked to their ADP-ribosyltransferase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice

1 reference

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7 January 2021

Mucosal immunization of mice using CpG DNA and/or mutants of the heat-labile enterotoxin of Escherichia coli as adjuvants

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Antibody-dependent and -independent protection following intranasal immunization of mice with rotavirus particles

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Effectiveness of intranasal immunization with HIV-gp160 and an HIV-1 env CTL epitope peptide (E7) in combination with the mucosal adjuvant LT(R192G)

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https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Cellular kinetics of the intestinal immune response to cholera toxoid in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Transcutaneous immunization with bacterial ADP-ribosylating exotoxins, subunits, and unrelated adjuvants

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Translating cell biology into therapeutic advances in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice

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https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Disaggregation of Alzheimer beta-amyloid by site-directed mAb.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide

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https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Effects of frequent intranasal administration of adjuvant-combined influenza vaccine on the protection against virus infection

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Characterization of murine immunoglobulin G antibodies against human amyloid-beta1-42.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Mucosal delivery of inactivated influenza vaccine induces B-cell-dependent heterosubtypic cross-protection against lethal influenza A H5N1 virus infection

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Novel intranasal immunization techniques for antibody induction and protection of mice against gastric Helicobacter felis infection.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Intranasal immunization of mice with PspA (pneumococcal surface protein A) can prevent intranasal carriage, pulmonary infection, and sepsis with Streptococcus pneumoniae

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

The role of Th1 and Th2 cells for mucosal IgA responses.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

Intranasal administration of 2/6-rotavirus-like particles with mutant Escherichia coli heat-labile toxin (LT-R192G) induces antibody-secreting cell responses but not protective immunity in gnotobiotic pigs

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2802%2900127-6

7 January 2021

10.1016/S0197-4580(02)00127-6

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22 September 2017

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