Coupled and uncoupled gating and desensitization effects by pore domain mutations in GABA(A) receptors. (Q40701047)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12351715%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

title

Coupled and uncoupled gating and desensitization effects by pore domain mutations in GABA(A) receptors (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12351715%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

1 reference

Michaela Scheller

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12351715%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

Stuart A Forman

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12351715%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

language of work or name

English

0 references

publication date

1 October 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12351715%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12351715%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

volume

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12351715%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

issue

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12351715%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

page(s)

8411-8421

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12351715%20AND%20SRC:MED&resulttype=core&format=json

Subunit mutations affect ethanol actions on GABA(A) receptors expressed in Xenopus oocytes

13 December 2019

cites work

1 reference

12 December 2020

Agonist gating and isoflurane potentiation in the human gamma-aminobutyric acid type A receptor determined by the volume of a second transmembrane domain residue.

1 reference

12 December 2020

A hydrophobic photolabel inhibits nicotinic acetylcholine receptors via open-channel block following a slow step

1 reference

12 December 2020

Allosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine

1 reference

12 December 2020

Identification of transduction elements for benzodiazepine modulation of the GABA(A) receptor: three residues are required for allosteric coupling

1 reference

12 December 2020

The general anesthetic propofol slows deactivation and desensitization of GABA(A) receptors.

1 reference

12 December 2020

Effects of halothane on GABA(A) receptor kinetics: evidence for slowed agonist unbinding.

1 reference

12 December 2020

Mapping the conformational wave of acetylcholine receptor channel gating

1 reference

12 December 2020

Asymmetric and independent contribution of the second transmembrane segment 12' residues to diliganded gating of acetylcholine receptor channels: a single-channel study with choline as the agonist

1 reference

12 December 2020

Mutating the highly conserved second membrane-spanning region 9' leucine residue in the alpha(1) or beta(1) subunit produces subunit-specific changes in the function of human alpha(1)beta(1) gamma-aminobutyric Acid(A) receptors.

1 reference

12 December 2020

Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol

1 reference

12 December 2020

Allosteric modulation in spontaneously active mutant gamma-aminobutyric acid(A) receptors [corrected].

1 reference

12 December 2020

Slow desensitization regulates the availability of synaptic GABA(A) receptors

1 reference

12 December 2020

Modeling the functional effects of allosteric modulators at pharmacological receptors: an extension of the two-state model of receptor activation.

1 reference

12 December 2020

The n-alcohol site in the nicotinic receptor pore is a hydrophobic patch

1 reference

12 December 2020

Butanol effects on gamma-amino butyric acid concentration-responses in human alpha1beta2gamma2L gamma-amino butyric acid type A receptors with a mutation at alpha1S270.

1 reference

12 December 2020

Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility method

1 reference

12 December 2020

Structural determinants of fast desensitization and desensitization-deactivation coupling in GABAa receptors.

1 reference

12 December 2020

Protein mobility and GABA-induced conformational changes in GABA(A) receptor pore-lining M2 segment

1 reference

12 December 2020

Dominant gating governing transient GABA(A) receptor activity: a first latency and Po/o analysis.

1 reference

12 December 2020

Mutation of the 9' leucine in the GABA(A) receptor gamma2L subunit produces an apparent decrease in desensitization by stabilizing open states without altering desensitized states

1 reference

12 December 2020

Stable expression of mammalian type A gamma-aminobutyric acid receptors in mouse cells: demonstration of functional assembly of benzodiazepine-responsive sites

1 reference

12 December 2020

Functional properties of recombinant rat GABAA receptors depend upon subunit composition

1 reference

12 December 2020

Spontaneous and agonist-induced openings of an acetylcholine receptor channel composed of bovine muscle ?-, ? and ?-subunits

1 reference

12 December 2020

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

1 reference

12 December 2020

Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology

1 reference

12 December 2020

High-efficiency transformation of mammalian cells by plasmid DNA

1 reference

12 December 2020

Conformations of Torpedo acetylcholine receptor associated with ion transport and desensitization

1 reference

12 December 2020

Desensitized states prolong GABAA channel responses to brief agonist pulses.

1 reference

12 December 2020

The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating

1 reference

12 December 2020

Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors

1 reference

12 December 2020

Evolutionary history of the ligand-gated ion-channel superfamily of receptors

1 reference

12 December 2020

Acetylcholine receptor channel imaged in the open state

1 reference

12 December 2020

Visual identification of individual transfected cells for electrophysiology using antibody-coated beads

1 reference

12 December 2020

Multiphasic desensitization of the GABAA receptor in outside-out patches

1 reference

12 December 2020

How quickly can GABAA receptors open?

1 reference

12 December 2020

Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes

1 reference

12 December 2020

Point mutations in the M2 region of the alpha, beta, or gamma subunit of the GABAA channel that abolish block by picrotoxin

1 reference

12 December 2020

Stoichiometry of a recombinant GABAA receptor.

1 reference

12 December 2020

Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit

1 reference

12 December 2020

Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins.

1 reference

12 December 2020

Dependence of the GABAA receptor gating kinetics on the alpha-subunit isoform: implications for structure-function relations and synaptic transmission.

1 reference

12 December 2020

Endogenous subunits can cause ambiguities in the pharmacology of exogenous gamma-aminobutyric acidA receptors expressed in human embryonic kidney 293 cells

1 reference

12 December 2020

Effects of mutating leucine to threonine in the M2 segment of alpha1 and beta1 subunits of GABAA alpha1beta1 receptors

1 reference

12 December 2020

Distinct deactivation and desensitization kinetics of recombinant GABAA receptors

1 reference

12 December 2020

Hydrophobicity regained.

1 reference

12 December 2020

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

1 reference

12 December 2020

Substitutions of the Highly Conserved M2 Leucine Create Spontaneously Opening ρ1 γ-Aminobutyric Acid Receptors

1 reference

12 December 2020

State-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor. Inferences from rates of reaction of thiosulfonates with substituted cysteines in the M2 segment of the alpha subunit

1 reference

12 December 2020

International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function

1 reference

12 December 2020

The location of the gate in the acetylcholine receptor channel

1 reference

12 December 2020

Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism

1 reference

12 December 2020

GABAA receptor subunit gamma2 and delta subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblasts

1 reference

12 December 2020

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

1 reference

12 December 2020

Molecular modulation of recombinant rat alpha1beta2gamma2 GABA(A) receptor channels by diazepam

1 reference

12 December 2020

Novel modulation of a nicotinic receptor channel mutant reveals that the open state is stabilized by ethanol

1 reference

12 December 2020

10.1523/JNEUROSCI.22-19-08411.2002

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12351715%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12351715%20AND%20SRC:MED&resulttype=core&format=json

13 December 2019

PubMed publication ID

12351715

1 reference