Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma (Q40702649)

22 September 2017

Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma (English)

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22 September 2017

Frédéric Pene

1

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22 September 2017

Yann-Erick Claessens

2

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22 September 2017

Odile Muller

3

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22 September 2017

Franck Viguié

4

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22 September 2017

Patrick Mayeux

5

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22 September 2017

François Dreyfus

6

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22 September 2017

Catherine Lacombe

7

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22 September 2017

Didier Bouscary

8

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22 September 2017

language of work or name

English

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publication date

1 September 2002

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22 September 2017

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22 September 2017

21

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22 September 2017

6587-6597

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22 September 2017

43

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205923

22 September 2017

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cites work

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27(kip1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

Cellular survival: a play in three Akts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

Stem cell factor/c-kit up-regulates cyclin D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 S6 kinase pathway in spermatogonia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

Insulin-like growth factor induces the survival and proliferation of myeloma cells through an interleukin-6-independent transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

The AKT kinase is activated in multiple myeloma tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

Role of the F-box protein Skp2 in lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

Constitutive activation of S6 kinase by deletion of amino-terminal autoinhibitory and rapamycin sensitivity domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

beta-catenin signaling and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

Cell-free degradation of p27(kip1), a G1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

BCR-ABL and interleukin 3 promote haematopoietic cell proliferation and survival through modulation of cyclin D2 and p27Kip1 expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

Phosphorylation and activation of p70s6k by PDK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

PIK3CA is implicated as an oncogene in ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p70(S6K)-independent signaling in growth factor-stimulated NIH 3T3 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

Cellular signaling: pivoting around PDK-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

p70s6k function is essential for G1 progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

inferred from DOI database lookup

7 January 2021

based on heuristic

Expression of PTEN in PTEN-deficient multiple myeloma cells abolishes tumor growth in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

inferred from DOI database lookup

7 January 2021

based on heuristic

PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205923

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1205923

1 reference

Dimensions Publication ID

22 September 2017

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1 reference