Oncogenic Ras/Her-2 mediate hyperproliferation of polarized epithelial cells in 3D cultures and rapid tumor growth via the PI3K pathway (Q40715312)

23 September 2017

title

Oncogenic Ras/Her-2 mediate hyperproliferation of polarized epithelial cells in 3D cultures and rapid tumor growth via the PI3K pathway (English)

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23 September 2017

4

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23 September 2017

Elzbieta Janda

1

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author name string

Gabi Litos

series ordinal

2

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23 September 2017

Stefan Grünert

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3

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23 September 2017

Hartmut Beug

series ordinal

5

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23 September 2017

language of work or name

English

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publication date

1 August 2002

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23 September 2017

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23 September 2017

volume

21

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23 September 2017

issue

33

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23 September 2017

page(s)

5148-5159

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Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

23 September 2017

cites work

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Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer

21 January 2018

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Signal transduction in mammary tumorigenesis: a transgenic perspective

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Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

21 January 2018

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Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

21 January 2018

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E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells

21 January 2018

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Multiple ras effector pathways contribute to G(1) cell cycle progression

21 January 2018

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Activation of mitogen-activated protein kinase is necessary but not sufficient for proliferation of human thyroid epithelial cells induced by mutant Ras.

21 January 2018

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Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways

21 January 2018

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Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

21 January 2018

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Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway

21 January 2018

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Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells

21 January 2018

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Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells

21 January 2018

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The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells

21 January 2018

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Isolation of EpH4 mammary epithelial cell subpopulations which differ in their morphogenetic properties

21 January 2018

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TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis

21 January 2018

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TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells

21 January 2018

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Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

21 January 2018

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Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1).

21 January 2018

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A causal role for E-cadherin in the transition from adenoma to carcinoma

21 January 2018

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Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells

21 January 2018

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Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

21 January 2018

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Analysis of the transcriptional program induced by Raf in epithelial cells

21 January 2018

1 reference

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Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

21 January 2018

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The conserved phosphoinositide 3-kinase pathway determines heart size in mice

21 January 2018

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Induction of transformation and DNA synthesis after microinjection of raf proteins

21 January 2018

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E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity

21 January 2018

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Functional intertwining of Dpp and EGFR signaling during Drosophila endoderm induction

21 January 2018

1 reference

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Activated MEK stimulates expression of AP-1 components independently of phosphatidylinositol 3-kinase (PI3-kinase) but requires a PI3-kinase signal To stimulate DNA synthesis

21 January 2018

1 reference

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Signaling pathways in Ras-mediated tumorigenicity and metastasis.

21 January 2018

1 reference

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Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

21 January 2018

1 reference

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Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase

21 January 2018

1 reference

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HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway

21 January 2018

1 reference

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Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

21 January 2018

1 reference

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Ras signaling through PI3K confers hormone-independent proliferation that is compatible with differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205661

7 January 2021

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205661

7 January 2021

Laminin and beta1 integrins are crucial for normal mammary gland development in the mouse

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205661

7 January 2021

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205661

7 January 2021

Transformation of mammalian cells by constitutively active MAP kinase kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205661

7 January 2021

Cadherin cell adhesion molecules in differentiation and embryogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205661

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205661

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Dimensions Publication ID

23 September 2017

1034222893

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1 reference