Overexpression of a dominant negative form of STAT3 selectively impairs hematopoietic stem cell activity (Q40720215)

23 September 2017

title

Overexpression of a dominant negative form of STAT3 selectively impairs hematopoietic stem cell activity (English)

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23 September 2017

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2

Connie J Eaves

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23 September 2017

Il-Hoan Oh

1

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23 September 2017

language of work or name

English

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publication date

1 July 2002

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23 September 2017

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23 September 2017

volume

21

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23 September 2017

issue

31

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23 September 2017

page(s)

4778-4787

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205592

23 September 2017

exact match

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cites work

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Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system.

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Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice

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STATs and gene regulation

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Proliferation of totipotent hematopoietic stem cells in vitro with retention of long-term competitive in vivo reconstituting ability

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High-efficiency retroviral transduction of mammalian cells on positively charged surfaces.

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STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells

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STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line

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Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3

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IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways

21 January 2018

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Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice

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Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium

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Essential role of STAT3 for embryonic stem cell pluripotency

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Mutational analysis of acute-phase response factor/Stat3 activation and dimerization

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Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3

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Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy

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Quantitation of murine and human hematopoietic stem cells by limiting-dilution analysis in competitively repopulated hosts

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Gp130 and the interleukin-6 family of cytokines

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Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders

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Cytokine manipulation of primitive human hematopoietic cell self-renewal

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Requirement of serine phosphorylation for formation of STAT-promoter complexes

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Stat3 plays an important role in oncogenic Ros- and insulin-like growth factor I receptor-induced anchorage-independent growth

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Expression of granulocyte colony-stimulating factor- and granulocyte-macrophage colony-stimulating factor-associated signal transduction proteins of the JAK/STAT pathway in normal granulopoiesis and in blast cells of acute myelogenous leukemia

21 January 2018

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7 January 2021

STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription

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7 January 2021

Stat3 and G-CSF-induced myeloid differentiation

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7 January 2021

A safe packaging line for gene transfer: separating viral genes on two different plasmids

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7 January 2021

Culture of purified stem cells from fetal liver results in loss of in vivo repopulating potential

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205592

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205592

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Dimensions Publication ID

23 September 2017

1051799037

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