ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase (Q40744542)

23 September 2017

ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase (English)

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23 September 2017

Cheng Fang Yu

1

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23 September 2017

Zhen-Xiang Liu

series ordinal

2

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23 September 2017

Lloyd G Cantley

series ordinal

3

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23 September 2017

language of work or name

English

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publication date

14 March 2002

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Journal of Biological Chemistry

23 September 2017

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23 September 2017

277

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23 September 2017

19382-19388

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23 September 2017

22

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Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

23 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200732200

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200732200

Expression of Gab1 lacking the pleckstrin homology domain is associated with neoplastic progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200732200

The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200732200

Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200732200

ERK regulates the hepatocyte growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200732200

Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200732200

Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200732200

Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200732200

Activated ERK2 interacts with and phosphorylates the docking protein GAB1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200732200

Targeting of constitutively active phosphoinositide 3-kinase to GLUT4-containing vesicles in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200732200

The multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200732200

Differential MAPK pathways utilized for HGF- and EGF-dependent renal epithelial morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200732200

Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200732200

A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200732200

Differential tubulogenic and branching morphogenetic activities of growth factors: implications for epithelial tissue development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200732200

21 January 2018

Identifiers

DOI

10.1074/JBC.M200732200

1 reference

23 September 2017

1 reference