Mechanism of alpha-subunit selectivity of benzodiazepine pharmacology at gamma-aminobutyric acid type A receptors (Q40748359)

23 September 2017

title

Mechanism of alpha-subunit selectivity of benzodiazepine pharmacology at gamma-aminobutyric acid type A receptors (English)

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23 September 2017

Peter B Wingrove

1

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23 September 2017

Patrick Safo

2

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23 September 2017

Lola Wheat

3

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23 September 2017

Sally A Thompson

4

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23 September 2017

Keith A Wafford

5

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23 September 2017

Paul J Whiting

6

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23 September 2017

language of work or name

English

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publication date

1 February 2002

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European Journal of Pharmacology

23 September 2017

published in

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23 September 2017

volume

437

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23 September 2017

issue

1-2

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23 September 2017

page(s)

31-39

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Pharmacology of recombinant gamma-aminobutyric acidA receptors rendered diazepam-insensitive by point-mutated alpha-subunits.

23 September 2017

cites work

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theta, a novel gamma-aminobutyric acid type A receptor subunit

7 January 2021

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Photoaffinity Labelling of the Benzodiazepine Receptor Compromises the Recognition Site but Not Its Effector Mechanism

7 January 2021

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A point mutation in the gamma2 subunit of gamma-aminobutyric acid type A receptors results in altered benzodiazepine binding site specificity

7 January 2021

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Identification of amino acid residues responsible for the alpha5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABA(A) receptor

7 January 2021

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

7 January 2021

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Identification of a unique domain in bovine brain GABAA receptors that is photoaffinity labelled by [3H]Ro15-4513.

7 January 2021

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Identification of domains in human recombinant GABAA receptors that are photoaffinity labelled by [3H]flunitrazepam and [3H]Ro15-4513.

7 January 2021

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Mapping of GABAA receptor sites that are photoaffinity-labelled by [3H]flunitrazepam and [3H]Ro 15-4513.

7 January 2021

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The major site of photoaffinity labeling of the gamma-aminobutyric acid type A receptor by [3H]flunitrazepam is histidine 102 of the alpha subunit.

7 January 2021

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Benzodiazepine receptor photoaffinity labeling: correlation of function with binding

7 January 2021

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A simple method for displaying the hydropathic character of a protein

7 January 2021

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Cerebellar GABAA receptor selective for a behavioural alcohol antagonist

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Diazepam-insensitive [3H]Ro 15-4513 binding in intact cultured cerebellar granule cells.

7 January 2021

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Photoaffinity labeling of the benzodiazepine binding site of alpha1beta3gamma2 gamma-aminobutyric acidA receptors with flunitrazepam identifies a subset of ligands that interact directly with His102 of the alpha subunit and predicts orientation of t

7 January 2021

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gamma-Aminobutyric acid type A receptor point mutation increases the affinity of compounds for the benzodiazepine site

7 January 2021

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Amino acid residue 200 on the alpha1 subunit of GABA(A) receptors affects the interaction with selected benzodiazepine binding site ligands

7 January 2021

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Distinct agonist- and antagonist-binding sites on the glycine receptor

7 January 2021

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Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor

7 January 2021

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The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit

7 January 2021

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Key amino acids in the gamma subunit of the gamma-aminobutyric acidA receptor that determine ligand binding and modulation at the benzodiazepine site.

7 January 2021

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Cloning, pharmacological characteristics and expression pattern of the rat GABAA receptor alpha 4 subunit

7 January 2021

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Cloning and characterization of the human GABAA receptor alpha 4 subunit: identification of a unique diazepam-insensitive binding site

7 January 2021

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Two tyrosine residues on the alpha subunit are crucial for benzodiazepine binding and allosteric modulation of gamma-aminobutyric acidA receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901279-7

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0014-2999(02)01279-7

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23 September 2017

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