Inactivation of the INK4a/ARF locus and p53 in sporadic extrahepatic bile duct cancers and bile tract cancer cell lines (Q40756082)

23 September 2017

Inactivation of the INK4a/ARF locus and p53 in sporadic extrahepatic bile duct cancers and bile tract cancer cell lines (English)

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23 September 2017

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6

Christian Wittekind

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23 September 2017

Karel Caca

1

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23 September 2017

Jürgen Feisthammel

2

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23 September 2017

Karen Klee

3

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23 September 2017

Andrea Tannapfel

4

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23 September 2017

Helmut Witzigmann

5

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23 September 2017

Joachim Mössner

7

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23 September 2017

Frieder Berr

8

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23 September 2017

language of work or name

English

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publication date

1 February 2002

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International Journal of Cancer

23 September 2017

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23 September 2017

97

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23 September 2017

4

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23 September 2017

481-488

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describes a project that uses

23 September 2017

CC-CL-1

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cites work

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Alterations of the p53 tumor-suppressor gene and K-ras oncogene in perihilar cholangiocarcinomas from a high-incidence area.

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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

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The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

21 January 2018

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Establishment of a new extrahepatic bile duct carcinoma cell line, TFK-1.

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Two new human cholangiocarcinoma cell lines and their cytogenetics and responses to growth factors, hormones, cytokines or immunologic effector cells

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Comparison of p53 gene mutation and protein overexpression in colorectal carcinomas

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Correlations of partial and extensive methylation at the p14(ARF) locus with reduced mRNA expression in colorectal cancer cell lines and clinicopathological features in primary tumors

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Comparison of p53 and DNA content abnormalities in adenocarcinoma of the oesophagus and gastric cardia

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A cell cycle regulator potentially involved in genesis of many tumor types

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Mutational analysis of the p53 and K-ras genes and allelotype study of the Rb-1 gene for investigating the pathogenesis of combined hapatocellular-cholangiocellular carcinomas.

21 January 2018

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Assessment of the expression of p53, MIB-1 (Ki-67 antigen), and argyrophilic nucleolar organizer regions in carcinoma of the extrahepatic bile duct

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TP53 Mutations and mdm2 Protein Overexpression in Cholangiocarcinomas

21 January 2018

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Surgical management of 552 carcinomas of the extrahepatic bile ducts (gallbladder and periampullary tumors excluded). Results of the French Surgical Association Survey

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p53 mutagenesis in Klatskin tumors

21 January 2018

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Mutations of the p53 tumor suppressor gene and the ras gene family in intrahepatic cholangiocellular carcinomas in Japan and Thailand

21 January 2018

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Expression of apoptosis, proliferating cell nuclear antigen, and apoptosis-related antigens (bcl-2, c-myc, Fas, Lewis(y) and p53) in human cholangiocarcinomas and hepatocellular carcinomas

21 January 2018

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Somatic INK4a-ARF locus mutations: a significant mechanism of gene inactivation in squamous cell carcinomas of the head and neck

21 January 2018

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Chromosome 9p21 loss and p16 inactivation in primary sclerosing cholangitis-associated cholangiocarcinoma

21 January 2018

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Germ-line mutations of the p16INK4(MTS1) gene occur in a subset of patients with hepatocellular carcinoma

21 January 2018

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Frequency of homozygous deletion at p16/CDKN2 in primary human tumours

21 January 2018

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Multiple, unique, and common p53 mutations in a thorotrast recipient with four primary cancers

21 January 2018

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New p53 mutations in hilar cholangiocarcinoma

21 January 2018

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Aberrations of the K-ras, p53, and APC genes in extrahepatic bile duct cancer

21 January 2018

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p53 protein immunoreactivity in extrahepatic bile duct and gallbladder cancer: correlation with tumor grade and survival

21 January 2018

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Expression of p53 in adenocarcinoma of the gallbladder and bile ducts

21 January 2018

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An immunohistochemical study of p53 protein in gallbladder and extrahepatic bile duct/ampullary carcinomas

21 January 2018

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p53 Point mutations in dysplastic and cancerous ulcerative colitis lesions

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.1639

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23 September 2017

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