Effective cytotoxicity against human leukemias and chemotherapy-resistant leukemia cell lines by N-N-dimethylsphingosine (Q40756979)

23 September 2017

title

Effective cytotoxicity against human leukemias and chemotherapy-resistant leukemia cell lines by N-N-dimethylsphingosine (English)

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23 September 2017

David B Jendiroba

1

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23 September 2017

Jim Klostergaard

2

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23 September 2017

Afsaneh Keyhani

3

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23 September 2017

Lance Pagliaro

4

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23 September 2017

Emil J Freireich

5

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23 September 2017

publication date

1 March 2002

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23 September 2017

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23 September 2017

volume

26

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23 September 2017

issue

3

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23 September 2017

page(s)

301-310

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Characterization of cytotoxicity induced by sphingolipids in multidrug-resistant leukemia cells

23 September 2017

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Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses

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Regulation of protein kinase C by sphingosine and lysosphingolipids

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Stereospecific induction of apoptosis in U937 cells by N-octanoyl-sphingosine stereoisomers and N-octyl-sphingosine. The ceramide amide group is not required for apoptosis

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Suppression of bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation

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Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines

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N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide.

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Ceramide: an endogenous regulator of apoptosis and growth suppression.

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Cross-talk between ceramide and PKC activity in the control of apoptosis in WEHI-231

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Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis

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7 January 2021

Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells

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Ceramide signaling in apoptosis

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Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl-2, but not by CrmA.

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7 January 2021

Sphingosine-1-phosphate mobilizes intracellular calcium and activates transcription factor NF-kappa B in U937 cells

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Ca2+ mobilizing action of sphingosine in Jurkat human leukemia T cells. Evidence that sphingosine releases Ca2+ from inositol trisphosphate- and phosphatidic acid-sensitive intracellular stores through a mechanism independent of inositol trisphospha

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7 January 2021

Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide

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7 January 2021

Diverse effects of sphingosine on calcium mobilization and influx in differentiated HL-60 cells

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7 January 2021

Activation of caspase-3-like proteases in apoptosis induced by sphingosine and other long-chain bases in Hep3B hepatoma cells

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7 January 2021

Induction of apoptosis by sphingosine-1-phosphate in human hepatoma cells is associated with enhanced expression of bax gene product

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7 January 2021

"Cross talk" between the bioactive glycerolipids and sphingolipids in signal transduction

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7 January 2021

Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling

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7 January 2021

Lysophosphatidic acid inhibits Ca2+ signaling in response to epidermal growth factor receptor stimulation in human astrocytoma cells by a mechanism involving phospholipase C(gamma) and a G(alphai) protein

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7 January 2021

Cross-talk between phosphatidylinositol 3-kinase and sphingomyelinase pathways as a mechanism for cell survival/death decisions

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7 January 2021

Multidrug resistance modulators and doxorubicin synergize to elevate ceramide levels and elicit apoptosis in drug-resistant cancer cells

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7 January 2021

Accumulation of glucosylceramides in multidrug-resistant cancer cells

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7 January 2021

Ceramide-induced apoptosis of human thyroid cancer cells resistant to apoptosis by irradiation.

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7 January 2021

Ceramide mediates radiation-induced death of endothelium.

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7 January 2021

Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation

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7 January 2021

Protein kinase C targeting in antineoplastic treatment strategies

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7 January 2021

Potentiation of Apoptosis by Treatment With the Protein Kinase C-Specific Inhibitor Safingol in Mitomycin C-Treated Gastric Cancer Cells

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7 January 2021

Partial Inhibition of Multidrug Resistance by Safingol Is Independent of Modulation of P-glycoprotein Substrate Activities and Correlated with Inhibition of Protein Kinase C

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7 January 2021

Characterization of apoptosis induced by protein kinase C inhibitors and its modulation by the caspase pathway in acute promyelocytic leukaemia

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7 January 2021

Toxicity of the protein kinase C inhibitor safingol administered alone and in combination with chemotherapeutic agents

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7 January 2021

Combined cytotoxic action of paclitaxel and ceramide against the human Tu138 head and neck squamous carcinoma cell line

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7 January 2021

Inhibition by sphingosine of leukemic cell killing by human monocytes activated with interleukin-2: a possible role of protein kinase C.

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7 January 2021

10.1016/S0145-2126(01)00129-1

Identifiers

DOI

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23 September 2017

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