Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis (Q40765104)

23 September 2017

title

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis (English)

1 reference

Evangelos J Giamarellos-Bourboulis

23 September 2017

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6

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23 September 2017

Shih-Chin Cheng

1

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Mark S Gresnigt

Mark S Gresnigt

4

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Brendon P Scicluna

Brendon P Scicluna

2

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Olaf L. Cremer

Olaf L Cremer

10

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Tom van der Poll

19

Tom van der Poll

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23 September 2017

15

Marcus J Schultz

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23 September 2017

20

Mihai G Netea

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23 September 2017

18

Leo A B Joosten

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23 September 2017

Frank van de Veerdonk

13

Frank L van de Veerdonk

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23 September 2017

Rob J W Arts

3

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23 September 2017

Ekta Lachmandas

5

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23 September 2017

Matthijs Kox

7

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23 September 2017

Ganesh R Manjeri

8

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23 September 2017

Jori A L Wagenaars

9

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23 September 2017

Jenneke Leentjens

11

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23 September 2017

Anne J van der Meer

12

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23 September 2017

Marc J Bonten

14

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23 September 2017

Peter H G M Willems

16

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23 September 2017

Peter Pickkers

17

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23 September 2017

language of work or name

English

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publication date

7 March 2016

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23 September 2017

number of pages

8

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inferred from page(s)

published in

Nature Immunology

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23 September 2017

volume

17

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23 September 2017

issue

4

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23 September 2017

page(s)

406-413

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Severe sepsis and septic shock

23 September 2017

cites work

1 reference

Human monocytes undergo functional re-programming during sepsis mediated by hypoxia-inducible factor-1α.

21 January 2018

1 reference

Epigenetic coordination of acute systemic inflammation: potential therapeutic targets.

21 January 2018

1 reference

The interplay between central metabolism and innate immune responses

21 January 2018

1 reference

Survival in critical illness is associated with early activation of mitochondrial biogenesis

21 January 2018

1 reference

Cellular dysfunction in sepsis

21 January 2018

1 reference

Cellular energetic metabolism in sepsis: the need for a systems approach

21 January 2018

1 reference

Oxygen consumption of human peripheral blood mononuclear cells in severe human sepsis

21 January 2018

1 reference

Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans

21 January 2018

1 reference

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.

21 January 2018

1 reference

Signaling by target of rapamycin proteins in cell growth control

21 January 2018

1 reference

Metabolic roles of AMPK and metformin in cancer cells

21 January 2018

1 reference

Updates of mTOR inhibitors

21 January 2018

1 reference

The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans

21 January 2018

1 reference

Role of tumor necrosis factor-α in the human systemic endotoxin-induced transcriptome

21 January 2018

1 reference

A network-based analysis of systemic inflammation in humans

21 January 2018

1 reference

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity.

21 January 2018

1 reference

NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response.

21 January 2018

1 reference

Reversal of immunoparalysis in humans in vivo: a double-blind, placebo-controlled, randomized pilot study.

21 January 2018

1 reference

Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series

21 January 2018

1 reference

Cellular metabolism and macrophage functional polarization

21 January 2018

1 reference

Direct type I IFN but not MDA5/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation

21 January 2018

1 reference

Association between mitochondrial dysfunction and severity and outcome of septic shock

21 January 2018

1 reference

Metabolic assessment of gradual development of moderate experimental colitis in IL-10 deficient mice.

21 January 2018

1 reference

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

21 January 2018

1 reference

Regulation of innate immune cell function by mTOR.

21 January 2018

1 reference

Macrophages, meta-inflammation, and immuno-metabolism.

21 January 2018

1 reference

PPARγ contributes to PKM2 and HK2 expression in fatty liver

21 January 2018

1 reference

Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation

21 January 2018

1 reference

Peroxisome proliferator-activated receptor-γ activation prevents sepsis-related cardiac dysfunction and mortality in mice

21 January 2018

1 reference

PPAR-γ/IL-10 axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis

21 January 2018

1 reference

A systematic review of experimental treatments for mitochondrial dysfunction in sepsis and multiple organ dysfunction syndrome.

21 January 2018

1 reference

Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation

21 January 2018

1 reference

Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling

21 January 2018

1 reference

MicroRNA-146a and RBM4 form a negative feed-forward loop that disrupts cytokine mRNA translation following TLR4 responses in human THP-1 monocytes

21 January 2018

1 reference

Interferon-γ-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells

21 January 2018

1 reference

IFN-γ and TNF-α synergistically induce microRNA-155 which regulates TAB2/IP-10 expression in human mesangial cells.

21 January 2018

1 reference

Succinate is an inflammatory signal that induces IL-1β through HIF-1α.

21 January 2018

1 reference

Interferon gamma (IFN-γ) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription

21 January 2018

1 reference

Interobserver agreement of Centers for Disease Control and Prevention criteria for classifying infections in critically ill patients

21 January 2018

1 reference

Electronic implementation of a novel surveillance paradigm for ventilator-associated events. Feasibility and validation.

21 January 2018

1 reference

APACHE II: a severity of disease classification system

21 January 2018

1 reference

affy--analysis of Affymetrix GeneChip data at the probe level

21 January 2018

1 reference

Independent filtering increases detection power for high-throughput experiments

21 January 2018

1 reference

Capturing heterogeneity in gene expression studies by surrogate variable analysis

21 January 2018

1 reference

Adjusting batch effects in microarray expression data using empirical Bayes methods

21 January 2018

1 reference

Bioconductor: open software development for computational biology and bioinformatics

21 January 2018

1 reference

beadarray: R classes and methods for Illumina bead-based data.

21 January 2018

1 reference

A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

21 January 2018

1 reference

arrayQualityMetrics--a bioconductor package for quality assessment of microarray data

21 January 2018

1 reference

oPOSSUM: integrated tools for analysis of regulatory motif over-representation

21 January 2018

1 reference

oPOSSUM: identification of over-represented transcription factor binding sites in co-expressed genes

21 January 2018

1 reference

ToppGene Suite for gene list enrichment analysis and candidate gene prioritization

21 January 2018

1 reference

IFN-γ priming of macrophages represses a part of the inflammatory program and attenuates neutrophil recruitment.

21 January 2018

1 reference

Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation

21 January 2018

1 reference

12 December 2020

NLRP3 and ASC differentially affect the lung transcriptome during pneumococcal pneumonia

1 reference

12 December 2020

Innate immune programing by endotoxin and its pathological consequences

1 reference

12 December 2020

Redox imbalance provokes deactivation of macrophages in sepsis

1 reference

12 December 2020

Monocyte deactivation in septic patients: restoration by IFN-gamma treatment

1 reference

12 December 2020

Identifiers

DOI

10.1038/NI.3398

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23 September 2017

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