Restoration of transforming growth factor-beta signaling enhances radiosensitivity by altering the Bcl-2/Bax ratio in the p53 mutant pancreatic cancer cell line MIA PaCa-2. (Q40770497)

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English	Restoration of transforming growth factor-beta signaling enhances radiosensitivity by altering the Bcl-2/Bax ratio in the p53 mutant pancreatic cancer cell line MIA PaCa-2.	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

23 September 2017

Restoration of transforming growth factor-beta signaling enhances radiosensitivity by altering the Bcl-2/Bax ratio in the p53 mutant pancreatic cancer cell line MIA PaCa-2. (English)

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

cancer cell line

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based on heuristic

inferred from title

pancreatic cancer

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based on heuristic

inferred from title

author name string

Mansoor M Ahmed

1

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Europe PubMed Central

PubMed publication ID

23 September 2017

Rachael A Alcock

2

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Europe PubMed Central

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23 September 2017

Damodaran Chendil

3

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Europe PubMed Central

PubMed publication ID

23 September 2017

Swatee Dey

4

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Europe PubMed Central

PubMed publication ID

23 September 2017

Anindita Das

5

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Kolaparthi Venkatasubbarao

6

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Mohammed Mohiuddin

7

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

LuZhe Sun

8

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

William E Strodel

9

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Europe PubMed Central

PubMed publication ID

23 September 2017

James W Freeman

10

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Europe PubMed Central

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23 September 2017

language of work or name

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publication date

1 November 2001

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Europe PubMed Central

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23 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

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23 September 2017

277

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Europe PubMed Central

PubMed publication ID

23 September 2017

3

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Europe PubMed Central

PubMed publication ID

23 September 2017

2234-2246

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Europe PubMed Central

PubMed publication ID

23 September 2017

Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

Increased tumorigenicity in the human pancreatic cell line MIA PaCa-2 is associated with an aberrant regulation of an IGF-1 autocrine loop and lack of expression of the TGF-beta type RII receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

TGF-beta stimulation and inhibition of cell proliferation: new mechanistic insights

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

Transforming growth factors and the regulation of cell proliferation

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https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

The role of growth regulatory aberrations in progression of human colon carcinoma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

TGF beta signals through a heteromeric protein kinase receptor complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

Mechanism of activation of the TGF-beta receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

Molecular mechanisms of transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

Loss of receptors for transforming growth factor beta in human T-cell malignancies.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-beta

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

Cancer. p53, guardian of the genome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

Restoration of the G1 checkpoint and the apoptotic pathway mediated by wild-type p53 sensitizes squamous cell carcinoma of the head and neck to radiotherapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

p53 mutations increase resistance to ionizing radiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

p53 is required for radiation-induced apoptosis in mouse thymocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

EGR-1 induction is required for maximal radiosensitivity in A375-C6 melanoma cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

Isolation of human glucose-6-phosphate dehydrogenase (G6PD) cDNA clones: primary structure of the protein and unusual 5' non-coding region

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

Radio-induced modulation of transforming growth factor beta1 sensitivity in a p53 wild-type human colorectal-cancer cell line

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

WAF1, a potential mediator of p53 tumor suppression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

Cdc2 and Cdk2 kinase activated by transforming growth factor-beta1 trigger apoptosis through the phosphorylation of retinoblastoma protein in FaO hepatoma cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

Transforming growth factor-beta-mediated apoptosis in the Ramos B-lymphoma cell line is accompanied by caspase activation and Bcl-XL downregulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110168200

21 January 2018

Identifiers

10.1074/JBC.M110168200

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

ResearchGate publication ID

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