Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation (Q40773928)

23 September 2017

Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation (English)

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23 September 2017

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H Zhou

1

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23 September 2017

S H Li

series ordinal

2

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23 September 2017

X J Li

series ordinal

3

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23 September 2017

language of work or name

English

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publication date

17 October 2001

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Journal of Biological Chemistry

23 September 2017

8

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based on heuristic

inferred from page(s)

published in

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23 September 2017

276

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23 September 2017

51

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23 September 2017

48417-48424

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Glutamine repeats and neurodegenerative diseases: molecular aspects

23 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Molecular chaperones in cellular protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Eukaryotic DnaJ homologs and the specificity of Hsp70 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Molecular chaperones: How J domains turn on Hsp70s

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

The chaperone function of hsp70 is required for protection against stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Negative regulation of the Apaf-1 apoptosome by Hsp70

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Genetic suppression of polyglutamine toxicity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

SNAREs and NSF in targeted membrane fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Intranuclear huntingtin increases the expression of caspase-1 and induces apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Huntingtin's neuroprotective activity occurs via inhibition of procaspase-9 processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Heat shock proteins: regulators of stress response and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Interaction of the N-ethylmaleimide-sensitive factor with AMPA receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104140200

21 January 2018

Identifiers

DOI

10.1074/JBC.M104140200

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1 reference