The Stat1 binding motif of the interferon-gamma receptor is sufficient to mediate Stat5 activation and its repression by SOCS3. (Q40778041)

23 September 2017

The Stat1 binding motif of the interferon-gamma receptor is sufficient to mediate Stat5 activation and its repression by SOCS3. (English)

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23 September 2017

I Woldman

1

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23 September 2017

L Varinou

2

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23 September 2017

K Ramsauer

3

1 reference

23 September 2017

B Rapp

4

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23 September 2017

T Decker

5

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23 September 2017

language of work or name

English

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publication date

27 September 2001

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Journal of Biological Chemistry

23 September 2017

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23 September 2017

276

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23 September 2017

49

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23 September 2017

45722-45728

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How cells respond to interferons

23 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

The molecular cell biology of interferon-gamma and its receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

The IFN gamma receptor: a paradigm for cytokine receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

GAS elements: a few nucleotides with a major impact on cytokine-induced gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Transcription factor activity of STAT proteins: structural requirements and regulation by phosphorylation and interacting proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Physiological significance of STAT proteins: investigations through gene disruption in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Activation of different Stat5 isoforms contributes to cell-type-restricted signaling in response to interferons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Stat5a is mandatory for adult mammary gland development and lactogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Negative regulators of cytokine signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

SOCS proteins, regulators of intracellular signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Negative regulation of cytokine signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

SOCS-3 is an insulin-induced negative regulator of insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Cloning and expression of murine immune interferon cDNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Differential Activation of Acute Phase Response Factor/STAT3 and STAT1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Stat1 combines signals derived from IFN-gamma and LPS receptors during macrophage activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Listeria monocytogenes modulates macrophage cytokine responses through STAT serine phosphorylation and the induction of suppressor of cytokine signaling 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Immune interferon: a pleiotropic lymphokine with multiple effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

T-cell-mediated activation of macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Roles of STAT3 defined by tissue-specific gene targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Jak2-Stat5 interactions analyzed in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Transcriptional inhibition by Stat5. Differential activities at growth-related versus differentiation-specific promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105320200

21 January 2018

Identifiers

DOI

10.1074/JBC.M105320200

1 reference

23 September 2017

1 reference