PI3-kinase p85alpha is a target molecule of proline-rich antimicrobial peptide to suppress proliferation of ras-transformed cells (Q40778525)

6 July 2018

title

PI3-kinase p85alpha is a target molecule of proline-rich antimicrobial peptide to suppress proliferation of ras-transformed cells (English)

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6 July 2018

main subject

antimicrobial peptide

1 reference

K Tanaka

1

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6 July 2018

Y Fujimoto

2

1 reference

6 July 2018

M Suzuki

3

1 reference

6 July 2018

Y Suzuki

4

1 reference

6 July 2018

T Ohtake

5

1 reference

6 July 2018

H Saito

6

1 reference

6 July 2018

Y Kohgo

7

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6 July 2018

publication date

1 September 2001

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6 July 2018

number of pages

9

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Japanese Journal of Cancer Research

inferred from page(s)

published in

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6 July 2018

volume

92

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6 July 2018

issue

9

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6 July 2018

page(s)

959-967

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6 July 2018

Inhibition of ubiquitin-proteasome pathway-mediated I kappa B alpha degradation by a naturally occurring antibacterial peptide

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In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002).

10 July 2018

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Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

10 July 2018

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Proline-rich antimicrobial peptide, PR-39 gene transduction altered invasive activity and actin structure in human hepatocellular carcinoma cells

10 July 2018

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Mitogen-activated protein kinase antisense oligonucleotide inhibits the growth of human lung cancer cells

10 July 2018

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A Sos-derived peptidimer blocks the Ras signaling pathway by binding both Grb2 SH3 domains and displays antiproliferative activity

10 July 2018

1 reference

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PR-39, a syndecan-inducing antimicrobial peptide, binds and affects p130(Cas).

10 July 2018

1 reference

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Selective cytotoxicity of farnesylamine to pancreatic carcinoma cells and Ki-ras-transformed fibroblasts

10 July 2018

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Rho GTPases and the actin cytoskeleton

10 July 2018

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

10 July 2018

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Dominant transformation by mutated human ras genes in vitro requires more than 100 times higher expression than is observed in cancers

10 July 2018

1 reference

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Specific activation of p85-p110 phosphatidylinositol 3'-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways

10 July 2018

1 reference

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Targeting signal transduction for disease therapy

10 July 2018

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Increased connexin-43 and gap junctional communication correlate with altered phenotypic characteristics of cells overexpressing the receptor for hyaluronic acid-mediated motility.

10 July 2018

1 reference

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Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926840

PR-39, a proline-rich antibacterial peptide that inhibits phagocyte NADPH oxidase activity by binding to Src homology 3 domains of p47 phox

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926840

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926840

The GTPase dynamin binds to and is activated by a subset of SH3 domains

10 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926840

10 July 2018

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A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926840

Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926840

Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926840

Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926840

Rho family GTPases bind to phosphoinositide kinases

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926840

Peptide antibiotics and their role in innate immunity

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926840

Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926840

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926840

Structural basis for the binding of proline-rich peptides to SH3 domains

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926840

ras oncogenes in human cancer: a review

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926840

Raf-1 activates MAP kinase-kinase

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926840

RAS pathways to cell cycle control and cell transformation

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926840

Regulation of the cell cycle machinery by oncogenic ras.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926840

A cDNA derived from pig bone marrow cells predicts a sequence identical to the intestinal antibacterial peptide PR-39.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926840

Amino acid sequence of PR-39. Isolation from pig intestine of a new member of the family of proline-arginine-rich antibacterial peptides

19 August 2018

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12 December 2020

PR39, a peptide regulator of angiogenesis

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12 December 2020

Interleukin-6 inhibits transforming growth factor-beta-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways

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12 December 2020

Reduced expression of syndecan-1 in human hepatocellular carcinoma with high metastatic potential

1 reference

12 December 2020

10.1111/J.1349-7006.2001.TB01187.X

Identifiers

DOI

1 reference

6 July 2018

PMCID

5926840

1 reference

6 July 2018

PubMed ID

11572764

1 reference

6 July 2018