A somatic mutation in the 5'UTR of BRCA1 gene in sporadic breast cancer causes down-modulation of translation efficiency. (Q40787469)

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10 November 2019

title

A somatic mutation in the 5'UTR of BRCA1 gene in sporadic breast cancer causes down-modulation of translation efficiency (English)

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10 November 2019

main subject

sporadic breast cancer

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1

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10 November 2019

Claudia Bagni

2

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10 November 2019

Vito Michele Fazio

7

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10 November 2019

author name string

Papa S

3

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10 November 2019

Primerano B

4

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10 November 2019

Rinaldi M

5

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10 November 2019

Amaldi F

6

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10 November 2019

language of work or name

English

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publication date

1 July 2001

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10 November 2019

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10 November 2019

volume

20

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10 November 2019

issue

33

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10 November 2019

page(s)

4596-4600

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1204620

10 November 2019

exact match

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cites work

A novel missense mutation in the amino-terminal domain of the human androgen receptor gene in a family with partial androgen insensitivity syndrome causes reduced efficiency of protein translation

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The 3' untranslated region of messenger RNA: A molecular 'hotspot' for pathology?

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Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors

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BRCA1 mutations in primary breast and ovarian carcinomas.

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Linkage of early-onset familial breast cancer to chromosome 17q21

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Strength of translation initiation signal sequence of mRNA as studied by quantification method: effect of nucleotide substitutions upon translation efficiency in rat preproinsulin mRNA.

21 January 2018

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Loss of nuclear BRCA1 expression in breast cancers is associated with a highly proliferative tumor phenotype

21 January 2018

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Initiation of translation in prokaryotes and eukaryotes

21 January 2018

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Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

21 January 2018

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An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

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Evaluation of the fidelity of initiation of translation in reticulocyte lysates from commercial sources

21 January 2018

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Recognition of AUG and alternative initiator codons is augmented by G in position +4 but is not generally affected by the nucleotides in positions +5 and +6.

21 January 2018

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Translational regulation of ribosomal protein synthesis in Xenopus cultured cells: mRNA relocation between polysomes and RNP during nutritional shifts

21 January 2018

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Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region

21 January 2018

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Somatic mutations in the BRCA1 gene in sporadic ovarian tumours.

21 January 2018

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Alpha-thalassemia due to the deletion of nucleotides -2 and -3 preceding the AUG initiation codon affects translation efficiency both in vitro and in vivo

21 January 2018

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Identification of a possible somatic BRCA1 mutation affecting translation efficiency in an early-onset sporadic breast cancer patient.

21 January 2018

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Aberrant methylation of the BRCA1 CpG island promoter is associated with decreased BRCA1 mRNA in sporadic breast cancer cells

21 January 2018

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Inherited breast and ovarian cancer.

21 January 2018

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21 January 2018

BRCA1 and cell signaling

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Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas

21 January 2018

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Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

21 January 2018

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Lessons learned from BRCA1 and BRCA2.

21 January 2018

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Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics

21 January 2018

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7 January 2021

Somatic mutations in the BRCA1 gene in Chinese sporadic breast and ovarian cancer

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7 January 2021

Immunolocalization of BRCA1 protein in normal breast tissue and sporadic invasive ductal carcinomas: a correlation with other biological parameters

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7 January 2021

Initiation of translation from a downstream in-frame AUG codon on BRCA1 can generate the novel isoform protein DeltaBRCA1(17aa)

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7 January 2021

Quantification of BRCA1 protein in sporadic breast carcinoma with or without loss of heterozygosity of the BRCA1 gene

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7 January 2021

BRCA1 expression levels predict distant metastasis of sporadic breast cancers

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7 January 2021

Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204620

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11494157%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

10 November 2019

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1 reference