Evidence for the vectorial nature of drug (substrate)-stimulated ATP hydrolysis by human P-glycoprotein (Q40792758)

23 September 2017

Evidence for the vectorial nature of drug (substrate)-stimulated ATP hydrolysis by human P-glycoprotein (English)

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23 September 2017

Sauna ZE

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23 September 2017

Smith MM

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2

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23 September 2017

Müller M

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3

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23 September 2017

Ambudkar SV

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4

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23 September 2017

language of work or name

English

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publication date

12 July 2001

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Journal of Biological Chemistry

23 September 2017

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23 September 2017

276

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23 September 2017

36

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23 September 2017

33301-33304

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Biochemistry of multidrug resistance mediated by the multidrug transporter

23 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.C100369200

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.C100369200

The catalytic cycle of P-glycoprotein

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.C100369200

ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100369200

Characterization of the ATPase activity of purified Chinese hamster P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100369200

Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100369200

Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100369200

Correlation between steady-state ATP hydrolysis and vanadate-induced ADP trapping in Human P-glycoprotein. Evidence for ADP release as the rate-limiting step in the catalytic cycle and its modulation by substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100369200

X-ray structure of the magnesium(II).ADP.vanadate complex of the Dictyostelium discoideum myosin motor domain to 1.9 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100369200

P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100369200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100369200

Effect of modulators on the ATPase activity and vanadate nucleotide trapping of human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100369200

Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100369200

Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100369200

Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100369200

Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein. The two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100369200

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100369200

Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100369200

GTP-stimulated phosphorylation of P-glycoprotein in transporting vesicles from KB-V1 multidrug resistant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100369200

Stoichiometry of coupling of rhodamine 123 transport to ATP hydrolysis by P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100369200

Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100369200

Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100369200

Conformational changes in four regions of the Escherichia coli ArsA ATPase link ATP hydrolysis to ion translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100369200

Vanadate-induced trapping of nucleotides by purified maltose transport complex requires ATP hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100369200

21 January 2018

Identifiers

DOI

10.1074/JBC.C100369200

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23 September 2017

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