The significance of the metabolism of the neurohormone melatonin: antioxidative protection and formation of bioactive substances (Q40796347)

23 September 2017

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title

The significance of the metabolism of the neurohormone melatonin: antioxidative protection and formation of bioactive substances (English)

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23 September 2017

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2

Reiter RJ

1 reference

23 September 2017

Hardeland R

1

1 reference

PubMed ID

8272286

23 September 2017

Poeggeler B

series ordinal

3

1 reference

PubMed ID

8272286

23 September 2017

Tan DX

series ordinal

4

1 reference

23 September 2017

1 January 1993

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Neuroscience & Biobehavioral Reviews

23 September 2017

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23 September 2017

17

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23 September 2017

3

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23 September 2017

347-357

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The effect of environmental photoperiodicity on indole rhythms and locomotor activity in sighted and eye covered chickens

23 September 2017

1 reference

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7 January 2021

Photoperiodism and effects of indoleamines in a unicellular alga, Gonyaulax polyedra

1 reference

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7 January 2021

Methyltetrahydrofolic acid mediates N- and O-methylation of biogenic amines.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

In vivo formation of 5-methoxytryptamine from melatonin in rat

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

5-Methoxyindoles in pineal gland of cow, pig, sheep and rat

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Localization of melatonin in the digestive tract of the rat. Effect of maturation, diurnal variation, melatonin treatment and pinealectomy

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Effects of melatonin on vertebrate circadian systems

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Pinealectomy increases ouabain high-affinity binding sites and dissociation constant in rat cerebral cortex

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Peroxidative block of glucose utilization and survival in CNS neuronal cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

In vivo and in vitro effects of the pineal gland and melatonin on [Ca(2+) + Mg2+]-dependent ATPase in cardiac sarcolemma.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Protection of DNA damage by dietary restriction

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

2-[125I]iodomelatonin binding sites in hamster brain membranes: pharmacological characteristics and regional distribution

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Serotonin and melatonin synthesis in peripheral blood mononuclear cells: stimulation by interferon-gamma as part of an immunomodulatory pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Carcinogen-mediated oxidant formation and oxidative DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Structure--activity relationship of melatonin analogues

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Effects of 5-methoxy-N,N-dimethyltryptamine on central monoamine neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Day-night rhythm of 5-methoxytryptamine biosynthesis in the pineal gland of the golden hamster (Mesocricetus auratus)

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Potentiation by deprenyl of the autoreceptor-mediated inhibition of [3H]-5-hydroxytryptamine release by 5-methoxytryptamine

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Melatonin deacetylation: retinal vertebrate class distribution and Xenopus laevis tissue distribution.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Effect of the pineal gland on circadian rhythmicity of colony forming units for granulocytes and macrophages (CFU-GM) from rat bone marrow cell cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Hydroxyl radical production and lipid peroxidation parallels selective post-ischemic vulnerability in gerbil brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Reactive oxygen species and the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Biologically relevant metal ion-dependent hydroxyl radical generation. An update

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Regulation of melatonin in the harderian glands of golden hamsters

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Metabolism of exogenous melatonin in schizophrenic and non-schizophrenic volunteers

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

6‐methoxy‐1,2,3,4‐tetrahydro‐β‐carboline in pineal gland of chicken and cock

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

N-acetyl-5-methoxy kynurenamine, a brain metabolite of melatonin, is a potent inhibitor of prostaglandin biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

A melatonin agonist and N-acetyl-N2-formyl-5-methoxykynurenamine accelerate the reentrainment of the melatonin rhythm following a phase advance of the light-dark cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Structure-activity studies of melatonin analogues in prepubertal male rats

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Effects of protein restriction, melatonin administration, and short daylength on brain benzodiazepine receptors in prepubertal male rats

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Seasonal variations in pineal 5-methoxytryptophol (5-ML) concentrations and in the daily pattern of pineal 5-ML and melatonin in the desert rodent Jaculus orientalis: effect of prolonged illumination during the night

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Interactions of benzodiazepines and ?-carbolines with a histidine residue of the benzodiazepine receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Possible endocrine role of the pineal gland for 6-methoxytetrahydro-β-carboline, a putative endogenous neuromodulator of the [3H]imipramine recognition site

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Substituted tetrahydro-β-carbolines are possible candidates as endogenous ligand of the [3H]Imipramine recognition site

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Characterization of central melatonin receptors using 125I-melatonin

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

6-Methoxy-tetrahydro-beta-carboline in the retinae of rabbits and pigs

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Evidence for multiple serotonergic influences on LH release in ovariectomized rats and for modulation of their relative effectiveness by estrogen.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Melatonin can be differentially metabolized in the rat to produce N-acetylserotonin in addition to 6-hydroxy-melatonin

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

An investigation of demethylation in the metabolism of methoxytryptamine and methoxytryptophol

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Melatonin shifts human circadian rhythms according to a phase-response curve

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Interaction of melatonin with human lymphocytes: evidence for binding sites coupled to potentiation of cyclic AMP stimulated by vasoactive intestinal peptide and activation of cyclic GMP

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

The biosynthesis of 5-methoxy-N,N-dimethyltryptamine

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Inhibition of diazepam binding by tryptophan derivatives including melatonin and its brain metabolite N-acetyl-5-methoxy kynurenamine.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Effects of melatonin and 5-methoxytryptamine on sleep-wake patterns in the male rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Both hydroxy- and methoxyindoles modify basal temperature in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Relationships between methoxyindoles and hydroxyindoles formed from 5-hydroxytryptamine in rat pineal gland

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Pineal 5-methoxy tryptophol in man

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Effect of melatonin and 5-methoxytryptamine on sex steroids and thyroid hormones during the prespawning phase of the annual reproductive cycle in the freshwater teleost, Clarias batrachus

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Inhibitory actions of pineal indoles on steroidogenesis in isolated rat Leydig cells

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Behavioural and electrocortical power spectrum effects of 5-methoxytryptoline and other analogs after intraventricular administration in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Histological studies on the effects of pineal 5-methoxyindoles on the reproductive organs of the male golden hamster

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Distribution and stress-induced increase of glutamate and aspartate levels in discrete brain nuclei of rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Is 5-methoxytryptamine a pineal hormone?

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Circadian rhythmicity of the activity of hydroxyindole-O-methyl transferase (HIOMT) in the formation of melatonin and 5-methoxytryptophol in the pineal, retina, and harderian gland of the golden hamster

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Effect of pinealectomy and a constant high level of circulating melatonin or of 5-methoxytryptamine on the vasopressinergic innervation in the brain of the European hamster (Cricetus cricetus, L)

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Effect of 5-methoxytryptamine on testicular atrophy induced by experimental or natural short photo-periods in the golden hamster (Mesocricetus auratus)

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Effect of 5-methoxytryptophan and 5-methoxytryptamine on the reproductive system of the male golden hamster

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

The independency of an intact pineal gland of the inhibition by 5-methoxytryptamine of the reproductive organs in the male hamster

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

The pineal control of aging. The effects of melatonin and pineal grafting on the survival of older mice

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Melatonin, hydroxyl radical-mediated oxidative damage, and aging: a hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

The fluorometric determination of 5-methoxytryptamine in mammalian tissues and fluids

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

The effect of 5-methoxytryptamine on golden hamster gonads is not a consequence of its acetylation into melatonin.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Low ambient temperature does not affect the pineal concentrations of either 5-methoxytryptamine or melatonin in golden hamsters kept under short photoperiod.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Effect of different photoperiods on the diurnal rhythm of 5-methoxytryptamine in the pineal gland of golden hamsters (Mesocricetus auratus)

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Plasma concentrations of 5-methoxytryptamine, 5-methoxytryptophol and melatonin after 5-methoxytryptamine administration of golden hamsters: physiological implications

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

The Pineal and Its Hormones in the Control of Reproduction in Mammals*

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Action spectra, dose-response relationships, and temporal aspects of light's effects on the pineal gland

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

The ageing pineal gland and its physiological consequences

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Relative efficacy of melatonin and 5-methoxytryptamine in terms of their antigonadotrophic and counterantigonadotrophic actions in male Syrian hamsters

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Solubilization and purification of melatonin receptors from lizard brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Melatonin: deacetylation to 5-methoxytryptamine by liver but not brain aryl acylamidase

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Ability of tryptophan derivatives to mimic melatonin's action upon the Syrian hamster reproductive system.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Central gabaergic mechanisms as targets for melatonin activity in brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Interaction of putative endogenous tryptolines with the hypothalamic serotonergic system and prolactin secretion in adult male rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Effect of different photoperiods on concentrations of 5-methoxytryptophol and melatonin in the pineal gland of the Syrian hamster.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

5-Methoxytryptophol injections in the Syrian hamster: plasma and pineal concentrations.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: effect of age and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Effects of 6-Methoxy-l,2,3,4-tetrahydro-b-carboline and Yohimbine on Hypothalamic Monoamine Status and Pituitary Hormone Release in the Rat

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Melatonin binding sites in the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Melatonin receptors: current status, facts, and hypotheses

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Monoamine oxidase, brain ageing and degenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Involvement of cysteine, serotonin and their analogues in peroxidase-oxidase reactions

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Melatonin: a coordinating signal for mammalian reproduction?

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Effects of 5-methoxy-N,N-dimethyltryptamine on behavior and raphe unit acitivity in freely moving cats

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Isolation, structure, and properties of the beta-carboline formed from 5-hydroxytryptamine by the superoxide anion-generating system.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Circadian rhythms in lizards: phase response curve for melatonin.

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Presence of immunoreactive melatonin in different tissues of the pigeon (Columba livia).

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

A cyclic isomer of 2-hydroxymelatonin: a novel metabolite of melatonin

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Alterations in Nocturnal Serum Melatonin Levels In Humans With Growth and Aging*

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Is Parkinson's disease a progressive siderosis of substantia nigra resulting in iron and melanin induced neurodegeneration?

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Melatonin is metabolized to N-acetyl serotonin and 6-hydroxymelatonin in man

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

Persistence of Circadian Rhythms of Melatonin and N-Acetylserotonin in the Serum of Rats after Pinealectomy

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

A proposal for reconsideration of the role of oxygen free radicals in cell differentiation and aging

1 reference

https://api.crossref.org/works/10.1016%2FS0149-7634%2805%2980016-8

7 January 2021

10.1016/S0149-7634(05)80016-8

Identifiers

DOI

1 reference

23 September 2017

1 reference

PubMed ID

8272286