High level resistance to glucocorticoids, associated with a dysfunctional glucocorticoid receptor, in childhood acute lymphoblastic leukemia cells selected for methotrexate resistance. (Q40797616)

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English	High level resistance to glucocorticoids, associated with a dysfunctional glucocorticoid receptor, in childhood acute lymphoblastic leukemia cells selected for methotrexate resistance.	scientific article

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scholarly article

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8 November 2019

High level resistance to glucocorticoids, associated with a dysfunctional glucocorticoid receptor, in childhood acute lymphoblastic leukemia cells selected for methotrexate resistance (English)

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8 November 2019

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lymphoblastic leukemia

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3

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8 November 2019

4

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8 November 2019

6

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8 November 2019

author name string

V S Catts

1

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8 November 2019

M L Farnsworth

2

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8 November 2019

L H Lutze-Mann

5

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8 November 2019

publication date

1 June 2001

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8 November 2019

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8 November 2019

15

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8 November 2019

6

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8 November 2019

929-935

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8 November 2019

https://scigraph.springernature.com/pub.10.1038/sj.leu.2402128

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Survival after relapse in childhood acute lymphoblastic leukemia: impact of site and time to first relapse--the Children's Cancer Group Experience

1 reference

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Predinsome therapy of acute childhood leukemia: Prognosis and duration of response in 330 treated patients

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General features of steroid resistance in lymphoid cell lines

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CONTINUOUS CULTURE OF HUMAN LYMPHOBLASTS FROM PERIPHERAL BLOOD OF A CHILD WITH ACUTE LEUKEMIA.

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Glucocorticoid-receptor-gene defects and resistance to glucocorticoid-induced apoptosis in human leukemic cell lines

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Resistance to drugs associated with the multidrug resistance phenotype following selection with high-concentration methotrexate

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A comparative study on the pharmacokinetics of methotrexate in a dose range of 0.5 g to 33.6 g/m2 in children with acute lymphoblastic leukemia.

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Involvement ofMDR1 P-glycoprotein in multifactorial resistance to methotrexate

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P-glycoprotein-mediated methotrexate resistance in CCRF-CEM sublines deficient in methotrexate accumulation due to a point mutation in the reduced folate carrier gene.

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THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

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Isolation and characterization of dexamethasone-resistant mutants from human lymphoid cell line CEM-C7.

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Molybdate-sensitive and molybdate-resistant activation-labile glucocorticoid-receptor mutants of the human lymphoid cell line CEM-C7.

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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Involvement of the glucocorticoid receptor in stress-induced apoptosis of leukemic cells

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Bax membrane insertion during Fas(CD95)-induced apoptosis precedes cytochrome c release and is inhibited by Bcl-2.

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Bcl-2 inhibits a Fas-induced conformational change in the Bax N terminus and Bax mitochondrial translocation.

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Primary structure and expression of a functional human glucocorticoid receptor cDNA

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Identifiers

10.1038/SJ.LEU.2402128

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8 November 2019

Dimensions Publication ID

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1 reference

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8 November 2019

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