The cell cycle and drug discovery: the promise and the hope (Q40797884)

23 September 2017

The cell cycle and drug discovery: the promise and the hope (English)

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23 September 2017

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Brooks G

1

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PubMed ID

10481141

23 September 2017

La Thangue NB

series ordinal

2

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23 September 2017

1 October 1999

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23 September 2017

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23 September 2017

4

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23 September 2017

10

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23 September 2017

455-464

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Animal cell cycles and their control

23 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Cyclins and cyclin-dependent kinases: take your partners

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Cell cycle control and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Cell cycle regulatory molecules (cyclins, cyclin-dependent kinases and cyclin-dependent kinase inhibitors) and the cardiovascular system; potential targets for therapy?

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Checkpoint pathways come of age.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Arresting developments in the cardiac myocyte cell cycle: role of cyclin-dependent kinase inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1

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https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Role of the INK4a locus in tumor suppression and cell mortality.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

The regulation of E2F by pRB-family proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

A new component of the transcription factor DRTF1/E2F.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

p53: puzzle and paradigm

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Life, death, and the pursuit of apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Transcriptional activation by p53 correlates with suppression of growth but not transformation.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Sequence-specific transcriptional activation is essential for growth suppression by p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

E2F-1 functions in mice to promote apoptosis and suppress proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Tumor induction and tissue atrophy in mice lacking E2F-1

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Human Cancer Syndromes: Clues to the Origin and Nature of Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

A cell cycle regulator potentially involved in genesis of many tumor types

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Cyclin-D1 expression in node-positive (N+) and node-negative (N-) infiltrating human mammary carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Cyclin D1 and prognosis in human breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

The pathogenesis of atherosclerosis: a perspective for the 1990s

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Atherosclerosis — An Inflammatory Disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Local drug delivery for the prevention of restenosis. Fact, fancy, and future

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Randomised comparison of implantation of heparin-coated stents with balloon angioplasty in selected patients with coronary artery disease (Benestent II)

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Balloon angioplasty for the treatment of coronary in-stent restenosis: immediate results and 6-month angiographic recurrent restenosis rate

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

1 reference

7 January 2021

The future of antifungal therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

How viral oncogenes make the cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Regulation of the cell cycle by viral oncoproteins.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Human papillomaviruses in the pathogenesis of anogenital cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Chemical inhibitors of cyclin-dependent kinases.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Expression of cyclin-dependent kinase inhibitors in vascular disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Genetic engineering of vein grafts resistant to atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Cell cycle inhibition preserves endothelial function in genetically engineered rabbit vein grafts

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Prevention of graft coronary arteriosclerosis by antisense cdk2 kinase oligonucleotide

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

E2F decoy oligonucleotide for genetic engineering of vascular bypass grafts

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Role of laminin-1, collagen IV, and an autocrine factor(s) in regulated secretion by lacrimal acinar cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Inhibition of mesangial cell proliferation by E2F decoy oligodeoxynucleotide in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Apoptosis induced in mammalian cells by small peptides that functionally antagonize the Rb-regulated E2F transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Cytostatic gene therapy for vascular proliferative disorders with a constitutively active form of the retinoblastoma gene product

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

p53-dependent cell death/apoptosis is required for a productive adenovirus infection

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Transfer of wild-type p53 gene effectively inhibits vascular smooth muscle cell proliferation in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Camptothecin and taxol: discovery to clinic

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Taxol inhibits neointimal smooth muscle cell accumulation after angioplasty in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

The effect of the cyclin-dependent kinase inhibitor olomoucine on cell cycle kinetics

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Tyrphostin AG 494 blocks Cdk2 activation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Inhibition of Cdk2 activation by selected tyrphostins causes cell cycle arrest at late G1 and S phase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Coordinated changes in cell cycle machinery occur during keratinocyte terminal differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Differential expression of cell survival and cell cycle regulatory proteins in cutaneous squamoproliferative lesions

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Concurrent disruption of cell cycle associated genes in mantle cell lymphoma: a genotypic and phenotypic study of cyclin D1, p16, p15, p53 and pRb.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Over-expression and amplification of the CDC2 gene in leukaemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Preclinical development of camptothecin derivatives and clinical trials in pediatric oncology.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901400-2

7 January 2021

10.1016/S1359-6446(99)01400-2

Identifiers

DOI

1 reference

23 September 2017

1 reference

PubMed ID

10481141