Receptor proximity, not intermolecular orientation, is critical for triggering T-cell activation (Q40802102)

23 September 2017

Receptor proximity, not intermolecular orientation, is critical for triggering T-cell activation (English)

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23 September 2017

Cochran JR

1

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23 September 2017

Cameron TO

2

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23 September 2017

Stone JD

3

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23 September 2017

Lubetsky JB

4

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23 September 2017

Stern LJ

5

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23 September 2017

language of work or name

English

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publication date

30 May 2001

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Journal of Biological Chemistry

23 September 2017

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23 September 2017

276

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23 September 2017

30

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23 September 2017

28068-28074

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MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation

23 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

T cell receptor-MHC interactions up close

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

T cell antigen receptor signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Receptor clustering and transmembrane signaling in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Costimulatory regulation of T cell function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

The role of T-cell receptor dimerization in T-cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

A mathematical analysis of TCR serial triggering and down-regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Protein tyrosine kinase structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

The two-component signaling pathway of bacterial chemotaxis: a molecular view of signal transduction by receptors, kinases, and adaptation enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Dimerization as a regulatory mechanism in signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Receptor signaling: when dimerization is not enough

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Sequence requirements for induction of cytolysis by the T cell antigen/Fc receptor zeta chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Multivalent structure of an alphabetaT cell receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Evidence for multivalent structure of T-cell antigen receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

The immunological synapse: a molecular machine controlling T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Empty and peptide-loaded class II major histocompatibility complex proteins produced by expression in Escherichia coli and folding in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Cutting edge: detection of antigen-specific CD4+ T cells by HLA-DR1 oligomers is dependent on the T cell activation state

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

The human class II MHC protein HLA-DR1 assembles as empty alpha beta heterodimers in the absence of antigenic peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Serial triggering of many T-cell receptors by a few peptide-MHC complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

The multi-subunit interleukin-2 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

The transferrin receptor: role in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Antigen-specific signaling by a soluble, dimeric peptide/major histocompatibility complex class II/Fc chimera leading to T helper cell type 2 differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Potent T cell activation with dimeric peptide-major histocompatibility complex class II ligand: the role of CD4 coreceptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Controlling signal transduction with synthetic ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Efficiency of signalling through cytokine receptors depends critically on receptor orientation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Structure and function of the T-cell receptor: insights from X-ray crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

The structure of MHC class II: a role for dimer of dimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Membrane rafts and signaling by the multichain immune recognition receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Determination of the relationship between T cell responsiveness and the number of MHC-peptide complexes using specific monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Conformation of human leukocyte antigen class II molecules. Evidence for superdimers and empty molecules on human antigen presenting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Detection of dimers of dimers of human leukocyte antigen (HLA)-DR on the surface of living cells by single-particle fluorescence imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Human major histocompatibility molecules have the intrinsic ability to form homotypic associations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

The expanding world of co-stimulation: the two-signal model revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

T cell activation determined by T cell receptor number and tunable thresholds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

CD8 Expression Allows T Cell Signaling by Monomeric Peptide-MHC Complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Human T-cell clones recognize chemically synthesized peptides of influenza haemagglutinin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Transcription factors in lymphocyte development--T and B cells get together

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

A diverse set of oligomeric class II MHC-peptide complexes for probing T-cell receptor interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

A conformational change in the human major histocompatibility complex protein HLA-DR1 induced by peptide binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Kinetics of T-cell receptor binding by bivalent HLA-DR. Peptide complexes that activate antigen-specific human T-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Phosphorylation of T cell receptor zeta is regulated by a lipid dependent folding transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

Transport of peptide-MHC class II complexes in developing dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

A receptor/cytoskeletal movement triggered by costimulation during T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103280200

21 January 2018

Identifiers

DOI

10.1074/JBC.M103280200

1 reference

23 September 2017

1 reference