Modulation of phospholipase D by hexadecylphosphorylcholine: a putative novel mechanism for its antitumoral activity (Q40810899)

23 September 2017

title

Modulation of phospholipase D by hexadecylphosphorylcholine: a putative novel mechanism for its antitumoral activity (English)

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23 September 2017

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4

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23 September 2017

Lucas L

1

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23 September 2017

Hernández-Alcoceba R

series ordinal

2

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23 September 2017

Penalva V

series ordinal

3

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23 September 2017

language of work or name

English

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publication date

1 March 2001

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23 September 2017

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23 September 2017

volume

20

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23 September 2017

issue

9

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23 September 2017

page(s)

1110-1117

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Inhibition of calcium-dependent protein kinase C by hexadecylphosphocholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine do not correlate with inhibition of proliferation of HL60 and K562 cell lines

23 September 2017

cites work

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7 January 2021

Inositol trisphosphate and calcium signalling

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7 January 2021

The regulation and cellular functions of phosphatidylcholine hydrolysis

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Lysophosphatidylcholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine inhibit the CDP-choline pathway of phosphatidylcholine synthesis at the CTP:phosphocholine cytidylyltransferase step.

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7 January 2021

Activation of intracellular kinases in Xenopus oocytes by p21ras and phospholipases: a comparative study

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7 January 2021

ras-p21 activates phospholipase D and A2, but not phospholipase C or PKC, in Xenopus laevis oocytes

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7 January 2021

Activation of phospholipase D by growth factors and oncogenes in murine fibroblasts follow alternative but cross-talking pathways.

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7 January 2021

Phospholipid analogue hexadecylphosphocholine inhibits proliferation and phosphatidylcholine biosynthesis of human epidermal keratinocytes in vitro

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7 January 2021

Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes

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7 January 2021

The phospholipid analogue hexadecylphosphocholine inhibits phosphatidylcholine biosynthesis in Madin-Darby canine kidney cells

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7 January 2021

The potential role for CDC42 protein from rat brain cytosol in phospholipase D activation.

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7 January 2021

The Ras family of GTPases in cancer cell invasion.

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7 January 2021

Choline kinase inhibitors as a novel approach for antiproliferative drug design

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7 January 2021

Phospholipid antitumor agents

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7 January 2021

Induction of in vitro tumor cell invasion of cellular monolayers by lysophosphatidic acid or phospholipase D.

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7 January 2021

Involvement of Ral GTPase in v-Src-induced phospholipase D activation

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7 January 2021

Generation of phosphorylcholine as an essential event in the activation of Raf-1 and MAP-kinases in growth factors-induced mitogenic stimulation.

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7 January 2021

Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture

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7 January 2021

Regulation of proliferation and apoptosis by Ras and Rho GTPases through specific phospholipid-dependent signaling

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7 January 2021

Diacylglycerol production in Xenopus laevis oocytes after microinjection of p21ras proteins is a consequence of activation of phosphatidylcholine metabolism

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7 January 2021

Phospholipase D and RalA cooperate with the epidermal growth factor receptor to transform 3Y1 rat fibroblasts

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7 January 2021

Ras protein is involved in the physiological regulation of phospholipase D by platelet derived growth factor.

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7 January 2021

The metabolism of phosphoinositide-derived messenger molecules.

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7 January 2021

Enhanced phospholipase D activity and altered morphology in RhoA-overexpressing RAT1 fibroblasts

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7 January 2021

Activation of serum response factor by RhoA is mediated by the nuclear factor-kappaB and C/EBP transcription factors

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7 January 2021

Inhibition of phospholipase C delta by hexadecylphosphorylcholine and lysophospholipids with antitumor activity

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7 January 2021

Phospholipase D activation by the mitogens platelet-derived growth factor and 12-O-tetradecanoylphorbol 13-acetate in NIH-3T3 cells

1 reference

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7 January 2021

Multiple sources of sn-1,2-diacylglycerol in platelet-derived-growth-factor-stimulated Swiss 3T3 fibroblasts. Evidence for activation of phosphoinositidase C and phosphatidylcholine-specific phospholipase D.

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7 January 2021

Alkylphosphocholines inhibit choline uptake and phosphatidylcholine biosynthesis in rat sympathetic neurons and impair axonal extension.

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7 January 2021

Inhibitors of phospholipid intracellular signaling as antiproliferative agents

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7 January 2021

v-Src increases diacylglycerol levels via a type D phospholipase-mediated hydrolysis of phosphatidylcholine

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7 January 2021

Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins.

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7 January 2021

Antagonism of phorbol-ester-stimulated phosphatidylcholine biosynthesis by the phospholipid analogue hexadecylphosphocholine

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7 January 2021

The antitumor phospholipid analog, hexadecylphosphocholine, activates cellular phospholipase D

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7 January 2021

Mechanisms of action of phospholipid analogs as anticancer compounds

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204216

1 reference

Dimensions Publication ID

23 September 2017

1042660287

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1 reference