Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner. (Q40821287)

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scientific article published on March 2001

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English	Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner.	scientific article published on March 2001

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5 November 2019

Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner (English)

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Alzheimer's disease

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T Niikura

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Y Hashimoto

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T Okamoto

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Y Abe

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T Yasukawa

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M Kawasumi

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T Hiraki

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Y Kita

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1 March 2001

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Journal of Neuroscience

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1902-1910

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

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12 December 2020

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c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1 reference

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12 December 2020

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In vivo coupling of insulin-like growth factor II/mannose 6-phosphate receptor to heteromeric G proteins. Distinct roles of cytoplasmic domains and signal sequestration by the receptor

1 reference

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12 December 2020

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Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3)

1 reference

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12 December 2020

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Effects of chronic renal failure on plasma clearance of insulin-like growth factor I, des-(1-3)IGF-I, and LR3IGF-I

1 reference

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12 December 2020

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Neuronal traits of clonal cell lines derived by fusion of dorsal root ganglia neurons with neuroblastoma cells

1 reference

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12 December 2020

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Role of PI3-kinase in Bcl-X induction and apoptosis inhibition mediated by IL-3 or IGF-1 in Baf-3 cells

1 reference

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Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

1 reference

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12 December 2020

based on heuristic

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V642I APP-inducible neuronal cells: a model system for investigating Alzheimer's disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

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Decreased plasma insulin-like growth factor-I level in familial Alzheimer's disease patients carrying the Swedish APP 670/671 mutation.

1 reference

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12 December 2020

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Insulin-like growth factor I receptor activated by a transmembrane mutation

1 reference

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12 December 2020

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The nerve growth factor: thirty-five years later

1 reference

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

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12 December 2020

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Synergistic action of R-Ras and IGF-1 on Bcl-xL expression and caspase-3 inhibition in BaF3 cells: R-Ras and IGF-1 control distinct anti-apoptotic kinase pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

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Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus.

1 reference

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12 December 2020

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Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

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IGF binding proteins: regulation of cellular actions

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

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Nerve growth factor withdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

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An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

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Insulin-like growth factor (IGF)-binding proteins inhibit the biological activities of IGF-1 and IGF-2 but not des-(1-3)-IGF-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

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Insulin-like growth factors in central nervous system tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

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Potential CRE suppression by familial Alzheimer's mutants of APP independent of adenylyl cyclase regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt regulates cell survival and apoptosis at a postmitochondrial level

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine kinases are required for catecholamine secretion and mitogen-activated protein kinase activation in bovine adrenal chromaffin cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

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The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-mimetic anti-insulin receptor monoclonal antibodies stimulate receptor kinase activity in intact cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Death of serum-free mouse embryo cells caused by epidermal growth factor deprivation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

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Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation

1 reference

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12 December 2020

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Gonadotropin suppression of apoptosis in cultured preovulatory follicles: mediatory role of endogenous insulin-like growth factor I

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of mutant amyloid precursor proteins induces apoptosis in PC12 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of cell death protease caspase-9 by phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Basic FGF attenuates amyloid beta-peptide-induced oxidative stress, mitochondrial dysfunction, and impairment of Na+/K+-ATPase activity in hippocampal neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity induces cleavage of p35 to p25 by calpain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis of vascular endothelial cells by fibroblast growth factor deprivation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatomedin-C levels in healthy young and old men: relationship to peak and 24-hour integrated levels of growth hormone

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity-dependent neurotrophic factor (ADNF). An extracellular neuroprotective chaperonin?

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of the growth inhibitor IGF-binding protein 3 by p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genistein, a specific inhibitor of tyrosine-specific protein kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple mechanisms underlie neurotoxicity by different types of Alzheimer's disease mutations of amyloid precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Death of PC12 cells and hippocampal neurons induced by adenoviral-mediated FAD human amyloid precursor protein gene expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell death and control of cell survival in the oligodendrocyte lineage

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low somatomedin-C levels in older men rise in response to growth hormone administration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IGF-1 Regulates Cardiac Fibroblast Apoptosis Induced by Osmotic Stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-dependent formation of a complex containing an 85-kDa subunit of phosphatidylinositol 3-kinase and tyrosine-phosphorylated insulin receptor substrate 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease families with amyloid precursor protein mutations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of somatomedins from human fetal brain: identification of a variant form of insulin-like growth factor I

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor 1 receptor-mediated endocytosis in Xenopus laevis oocytes. A role for receptor tyrosine kinase activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Framing beta-amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal apoptosis by apolipoprotein E4 through low-density lipoprotein receptor-related protein and heterotrimeric GTPases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid neurotoxicity in vitro: evidence of oxidative stress but not protection by antioxidants

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired growth hormone secretion in the adult population: relation to age and adiposity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wortmannin, a microbial product inhibitor of myosin light chain kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

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Rediscovering good old friend IGF-I in the new millenium: possible usefulness in Alzheimer's disease and stroke.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of binding proteins for insulin-like growth factors (IGF) in humans. Increased expression of IGF binding protein 2 during IGF I treatment of healthy adults and in patients with extrapancreatic tumor hypoglycemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11245675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.21-06-01902.2001

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5 November 2019

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Europe PubMed Central

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5 November 2019

1 reference

Europe PubMed Central

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5 November 2019

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