Adenovirus-E1A proteins transform cells by sequestering regulatory proteins (Q40823566)

24 September 2017

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title

Adenovirus-E1A proteins transform cells by sequestering regulatory proteins (English)

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24 September 2017

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D S Peeper

1

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24 September 2017

A Zantema

series ordinal

2

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24 September 2017

publication date

1 April 1993

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Molecular Biology Reports

24 September 2017

published in

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24 September 2017

volume

17

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24 September 2017

issue

3

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24 September 2017

page(s)

197-207

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Different functional domains of the adenovirus E1A gene are involved in regulation of host cell cycle products

24 September 2017

cites work

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https://api.crossref.org/works/10.1007%2FBF00986728

Association of adenovirus early-region 1A proteins with cellular polypeptides

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00986728

Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00986728

The retinoblastoma protein physically associates with the human cdc2 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00986728

Activation of human cyclin-dependent kinases in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00986728

Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00986728

Sequences in E1A proteins of human adenovirus 5 required for cell transformation, repression of a transcriptional enhancer, and induction of proliferating cell nuclear antigen.

21 January 2018

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12 December 2020

Immortalization of primary epithelial cells requires first- and second-exon functions of adenovirus type 5 12S.

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12 December 2020

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12 December 2020

Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: a novel mechanism for E1A trans-activation

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12 December 2020

The retinoblastoma protein is phosphorylated on multiple sites by human cdc2

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12 December 2020

Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E1A.

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12 December 2020

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

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12 December 2020

Cyclin A is required at two points in the human cell cycle

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12 December 2020

Comparison of nucleotide sequences of the early E1a regions for subgroups A, B and C of human adenoviruses

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12 December 2020

Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

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12 December 2020

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

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12 December 2020

Association of cdk2 Kinase with the Transcription Factor E2F During S Phase

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12 December 2020

Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein

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12 December 2020

Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides.

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12 December 2020

Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins

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12 December 2020

Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins

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12 December 2020

The role of cyclin B in meiosis I.

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12 December 2020

The adenovirus E4 17-kilodalton protein complexes with the cellular transcription factor E2F, altering its DNA-binding properties and stimulating E1A-independent accumulation of E2 mRNA.

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12 December 2020

Two regions of the adenovirus early region 1A proteins are required for transformation.

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12 December 2020

Dephosphorylation and activation of Xenopusp34 cdc2 protein kinase during the cell cycle

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12 December 2020

Creative blocks: cell-cycle checkpoints and feedback controls

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12 December 2020

Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase

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12 December 2020

Cyclin A is required in S phase in normal epithelial cells.

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12 December 2020

A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product

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12 December 2020

Adenovirus E1a ras cooperation activity is separate from its positive and negative transcription regulatory functions

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12 December 2020

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

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12 December 2020

Adenovirus E1A is associated with a serine/threonine protein kinase

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12 December 2020

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

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12 December 2020

Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function

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12 December 2020

Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase

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12 December 2020

TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains.

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12 December 2020

A novel function of the transforming domain of E1a: repression of AP-1 activity

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12 December 2020

SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family

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12 December 2020

Cell cycle regulation of the human cdc2 gene

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12 December 2020

Transcription activation by the adenovirus E1a protein

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12 December 2020

Oncogenes and signal transduction

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12 December 2020

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

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12 December 2020

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

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12 December 2020

An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F.

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12 December 2020

Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites

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12 December 2020

Activation of the E2F transcription factor in adenovirus-infected cells involves E1A-dependent stimulation of DNA-binding activity and induction of cooperative binding mediated by an E4 gene product

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12 December 2020

The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

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12 December 2020

Transcriptional and Transforming Activities of the Adenovirus E1A Proteins

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12 December 2020

Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF

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12 December 2020

An adenovirus E1A protein domain activates transcription in vivo and in vitro in the absence of protein synthesis

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12 December 2020

Differential effects of the adenovirus E1A oncogene on members of the AP-1 transcription factor family

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12 December 2020

The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T.

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12 December 2020

E1A induces phosphorylation of the retinoblastoma protein independently of direct physical association between the E1A and retinoblastoma products

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12 December 2020

Mutational analysis of autonomously functioning trans-activating peptides encoded by adenovirus E1A: evidence for two subdomains.

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12 December 2020

Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes

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12 December 2020

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport

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12 December 2020

Simian virus 40 large-T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene products

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12 December 2020

Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA.

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12 December 2020

Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

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12 December 2020

The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus

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12 December 2020

E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor

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12 December 2020

Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation

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12 December 2020

A first exon-encoded domain of E1A sufficient for posttranslational modification, nuclear-localization, and induction of adenovirus E3 promoter expression in Xenopus oocytes

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12 December 2020

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product

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12 December 2020

Expression, purification, and functional characterization of adenovirus 5 and 12 E1A proteins produced in insect cells

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12 December 2020

An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110Rb and a second cellular protein, p120.

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12 December 2020

Cyclin synthesis drives the early embryonic cell cycle

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12 December 2020

Purification and characterization of human papillomavirus type 16 E7 protein with preferential binding capacity to the underphosphorylated form of retinoblastoma gene product

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12 December 2020

Retinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis

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12 December 2020

Identification of separate domains in the adenovirus E1A gene for immortalization activity and the activation of virus early genes

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12 December 2020

Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering

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12 December 2020

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

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12 December 2020

Effects of Ad5 E1A mutant viruses on the cell cycle in relation to the binding of cellular proteins including the retinoblastoma protein and cyclin A

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12 December 2020

An N-terminal region of adenovirus E1a essential for cell transformation and induction of an epithelial cell growth factor

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12 December 2020

The adenovirus E4 gene, in addition to the E1A gene, is important for trans-activation of E2 transcription and for E2F activation

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12 December 2020

Adenovirus E1A protein paradigm viral transactivator

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12 December 2020

Induction of AP-1 DNA-binding activity and c-fos mRNA by the adenovirus 243R E1A protein and cyclic AMP requires domains necessary for transformation

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12 December 2020

The E2F transcription factor is a cellular target for the RB protein

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12 December 2020

cdc2-like kinase is associated with the retinoblastoma protein

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12 December 2020

Isolation and characterization of insertion mutants in E1A of adenovirus type 5

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12 December 2020

Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes

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12 December 2020

The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations

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12 December 2020

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

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12 December 2020

Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation

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12 December 2020

The repression of the growth factor-inducible genes JE, c-myc and stromelysin by adenovirus E1A is mediated by conserved region 1

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12 December 2020

Interaction between human cyclin A and adenovirus E1A-associated p107 protein

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12 December 2020

Adenovirus promoters and E1A transactivation

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12 December 2020

Adenovirus E1A activation domain binds the basic repeat in the TATA box transcription factor

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12 December 2020

Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts

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12 December 2020

Co-purification of p34cdc2/p58cyclin A proline-directed protein kinase and the retinoblastoma tumor susceptibility gene product: interaction of an oncogenic serine/threonine protein kinase with a tumor-suppressor protein

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12 December 2020

Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein

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12 December 2020

Human cyclin A and the retinoblastoma protein interact with similar but distinguishable sequences in the adenovirus E1A gene product

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12 December 2020

Mechanisms of transformation by polyoma virus middle T antigen

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12 December 2020

Differential activation of the E2F transcription factor by the adenovirus EIa and EIV products in F9 cells

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12 December 2020

The amino-terminal region of the adenovirus serotype 5 E1a protein performs two separate functions when expressed in primary baby rat kidney cells

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12 December 2020

A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells

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12 December 2020

Cellular targets for transformation by the adenovirus E1A proteins

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12 December 2020

When the products of oncogenes and anti-oncogenes meet

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12 December 2020

Mutational analysis of the adenovirus E1a gene: the role of transcriptional regulation in transformation

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12 December 2020

Enhanced ras oncogene mediated cell transformation and tumorigenesis by adenovirus 2 mutants lacking the C-terminal region of E1a protein.

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12 December 2020

Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate

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12 December 2020

A nexus between Oct-4 and E1A: implications for gene regulation in embryonic stem cells

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12 December 2020

trans-dominant mutants of E1A provide genetic evidence that the zinc finger of the trans-activating domain binds a transcription factor

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12 December 2020

Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A.

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12 December 2020

A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex.

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12 December 2020

Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein

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12 December 2020

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12 December 2020

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

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12 December 2020

Evidence for interaction of different eukaryotic transcriptional activators with distinct cellular targets

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12 December 2020

Complete transformation by adenovirus 2 requires both E1A proteins

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12 December 2020

Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F.

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12 December 2020

Cyclin activation of p34cdc2.

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12 December 2020

Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase

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12 December 2020

E1a regions of the human adenoviruses and of the highly oncogenic simian adenovirus 7 are closely related

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12 December 2020

The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

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12 December 2020

Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity

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12 December 2020

Use of deletion and point mutants spanning the coding region of the adenovirus 5 E1A gene to define a domain that is essential for transcriptional activation

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12 December 2020

G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment

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12 December 2020

An adenovirus E1a protein region required for transformation and transcriptional repression

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12 December 2020

The 289-amino acid E1A protein of adenovirus binds zinc in a region that is important for trans-activation

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12 December 2020

The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes

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12 December 2020

Modulation of transformation of primary epithelial cells by the second exon of the Ad5 E1A12S gene

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12 December 2020

Direct interaction between adenovirus E1A protein and the TATA box binding transcription factor IID

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12 December 2020

Interactions between cell growth-regulating domains in the products of the adenovirus E1A oncogene

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12 December 2020

Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement

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12 December 2020

Adenovirus E1A coding sequences that enable ras and pmt oncogenes to transform cultured primary cells

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12 December 2020

Identification of a cellular transcription factor involved in E1A trans-activation

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12 December 2020

Genetic dissection of the transactivating domain of the E1a 289R protein of adenovirus type 2

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12 December 2020

Mapping of functional domains in adenovirus E1A proteins

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12 December 2020

Adenovirus E1A makes two distinct contacts with the retinoblastoma protein

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12 December 2020

Cooperativity in transactivation between retinoic acid receptor and TFIID requires an activity analogous to E1A

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12 December 2020

Lytic and transforming functions of individual products of the adenovirus E1A gene.

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12 December 2020

Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B.

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12 December 2020

Functional domains of adenovirus type 5 E1a proteins.

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12 December 2020

The adenovirus E1A transforming protein activates the proliferating cell nuclear antigen promoter via an activating transcription factor site

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12 December 2020

Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

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12 December 2020

Growth factor induction by the adenovirus type 5 E1A 12S protein is required for immortalization of primary epithelial cells

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12 December 2020

Mapping of cellular protein-binding sites on the products of early-region 1A of human adenovirus type 5.

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12 December 2020

Independent transformation activity by adenovirus-5 E1A-conserved regions 1 or 2 mutants.

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12 December 2020

Role of E2F transcription factor in E1A-mediated trans activation of cellular genes

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12 December 2020

Retinoblastoma protein switches the E2F site from positive to negative element

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12 December 2020

Induction of transforming growth factor beta 1 resistance by the E1A oncogene requires binding to a specific set of cellular proteins.

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12 December 2020

The carboxy-terminal exon of the adenovirus E1A protein is required for E4F-dependent transcription activation

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12 December 2020

Identifiers

DOI

10.1007/BF00986728

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24 September 2017

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