Tripartite motif containing 5 (Q408249)

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mammalian protein found in Homo sapiens

• RING-type E3 ubiquitin transferase TRIM5
• ring finger protein 88
• tripartite motif containing 5 transcript variant kappa
• tripartite motif protein TRIM5
• tripartite motif containing 5 transcript variant iota
• TRIM5
• tripartite motif-containing protein 5

edit

Language	Label	Description	Also known as
English	Tripartite motif containing 5	mammalian protein found in Homo sapiens	RING-type E3 ubiquitin transferase TRIM5 ring finger protein 88 tripartite motif containing 5 transcript variant kappa tripartite motif protein TRIM5 tripartite motif containing 5 transcript variant iota TRIM5 tripartite motif-containing protein 5

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9C035

part of

Zinc finger, RING/FYVE/PHD-type

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9C035

Concanavalin A-like lectin/glucanase domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9C035

Tripartite motif-containing protein 5

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9C035

RING-type zinc-finger, LisH dimerisation motif, protein family

1 reference

based on heuristic

inferred from protein domain or family

Butyrophylin-like, SPRY domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

B30.2/SPRY domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

B-box-type zinc finger, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, RING-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

SPRY domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, RING-type, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9C035

encoded by

TRIM5

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9C035

molecular function

protein-macromolecule adaptor activity

determination method

IPI

1 reference

retrieved

8 April 2019

stated in

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IPI

protein homodimerization activity

determination method

IPI

1 reference

retrieved

8 April 2019

stated in

The tripartite motif family identifies cell compartments

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IPI

pattern recognition receptor activity

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IDA

zinc ion binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IEA

metal ion binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IEA

protein binding

determination method

IPI

6 references

retrieved

8 April 2019

stated in

TRIM5α associates with proteasomal subunits in cells while in complex with HIV-1 virions

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IPI

retrieved

8 April 2019

stated in

p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IPI

retrieved

8 April 2019

stated in

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IPI

retrieved

8 April 2019

stated in

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IPI

retrieved

8 April 2019

stated in

PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IPI

retrieved

8 April 2019

stated in

Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IPI

identical protein binding

determination method

IPI

2 references

retrieved

8 April 2019

stated in

TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IPI

retrieved

8 April 2019

stated in

Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IPI

protein kinase binding

determination method

IPI

1 reference

retrieved

8 April 2019

stated in

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IPI

transferase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IEA

ubiquitin-protein transferase activity

determination method

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IEA

retrieved

8 April 2019

stated in

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IDA

cell component

cytoplasm

determination method

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IEA

retrieved

8 April 2019

stated in

TRIM E3 ligases interfere with early and late stages of the retroviral life cycle

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IDA

retrieved

8 April 2019

stated in

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IDA

cytosol

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

TAS

omegasome

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IDA

intracellular anatomical structure

determination method

IEA

1 reference

retrieved

16 July 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9C035&geneProductId=UniProtKB:Q9C035

determination method

IEA

nucleus

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IEA

P-body

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IDA

biological process

regulation of lipopolysaccharide-mediated signaling pathway

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IMP

interferon-gamma-mediated signaling pathway

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

TAS

protein K63-linked ubiquitination

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IDA

immune system process

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IEA

protein trimerization

determination method

IDA

1 reference

retrieved

1 January 2018

stated in

Unique features of TRIM5alpha among closely related human TRIM family members

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9C035&geneProductId=UniProtKB:Q9C035

determination method

IDA

positive regulation of DNA-binding transcription factor activity

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IMP

regulation of protein localization

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IMP

autophagy

determination method

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IEA

retrieved

8 April 2019

stated in

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IDA

positive regulation of NF-kappaB transcription factor activity

determination method

IMP

2 references

retrieved

8 April 2019

stated in

TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IMP

retrieved

8 April 2019

stated in

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IMP

defense response to virus

determination method

TAS

IEA

4 references

retrieved

8 April 2019

stated in

TRIM5α and Species Tropism of HIV/SIV

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

TAS

retrieved

8 April 2019

stated in

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IEA

protein ubiquitination

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IEA

activation of innate immune response

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IDA

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method

IDA

IMP

2 references

retrieved

8 April 2019

stated in

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IMP

retrieved

8 April 2019

stated in

TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IDA

innate immune response

determination method

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IEA

retrieved

8 April 2019

stated in

TRIM E3 ligases interfere with early and late stages of the retroviral life cycle

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IDA

viral process

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IEA

positive regulation of MAPK cascade

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IMP

pattern recognition receptor signaling pathway

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IEA

negative regulation of viral entry into host cell

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

TRIM E3 ligases interfere with early and late stages of the retroviral life cycle

GOA

curator

UniProt

UniProt protein ID

Q9C035

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

determination method

IDA

Gene Atlas image

PBB GE TRIM5 210705 s at fs.png
732 × 530; 12 KB

0 references

exact match

http://purl.uniprot.org/uniprot/Q9C035

1 reference

stated in

Identifiers.org

has part(s)

Zinc finger, RING-type, conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9C035

Zinc finger, RING-type

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9C035

Butyrophylin-like, SPRY domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9C035

SPRY domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9C035

B30.2/SPRY domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9C035

RING-type zinc-finger, LisH dimerisation motif

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9C035

B-box-type zinc finger

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9C035

Identifiers

RefSeq protein ID

NP_149023

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

85363

NP_149083

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

85363

NP_149084

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

85363

XP_005253240

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

85363

XP_005253241

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

85363

XP_006718421

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

85363

XP_011518728

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

85363

XP_011518729

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

85363

XP_016873949

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

85363

XP_016873950

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

85363

XP_016873951

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

85363

XP_016873952

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

85363

UniProt protein ID

Q9C035

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9C035

Ensembl protein ID

ENSP00000369366

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000369366

ENSP00000369373

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000369373

ENSP00000380058

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000380058

ENSP00000393052

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000393052

ENSP00000388031

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000388031

ENSP00000388150

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000388150

ENSP00000398196

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000398196

Freebase ID

/m/04tk4h

1 reference

stated in

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

2779308994

0 references

PDB structure ID

2ECV

1 reference

stated in

UniProt

UniProt protein ID

Q9C035

retrieved

9 August 2016

language of work or name

English

2YRG

1 reference

stated in

UniProt

UniProt protein ID

Q9C035

retrieved

9 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(9 entries)

edit

• cswiki TRIM5alpha
• cywiki TRIM5
• dewiki TRIM5α
• enwiki TRIM5alpha
• eswiki TRIM5alfa
• nlwiki TRIM5α
• ptwiki TRIM5A
• ttwiki TRIM5
• ukwiki TRIM5

Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

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Wiktionary(0 entries)

edit

Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q408249&oldid=2022900962"