Cerebral ischemia: the microcirculation as trigger and target (Q40825929)

24 September 2017

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title

Cerebral ischemia: the microcirculation as trigger and target (English)

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24 September 2017

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Dirnagl U

1

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24 September 2017

language of work or name

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1 January 1993

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Progress in Brain Research

24 September 2017

published in

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24 September 2017

volume

96

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24 September 2017

page(s)

49-65

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Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger

24 September 2017

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Identification of hypoxanthine transport and xanthine oxidase activity in brain capillaries

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Ischemic brain damage in rats following cardiac arrest using a long-term recovery model

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Central nervous system trauma and stroke. I. Biochemical considerations for oxygen radical formation and lipid peroxidation

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7 January 2021

A new model of temporary focal neocortical ischemia in the rat

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7 January 2021

The effect of the NMDA receptor antagonist MK-801 on cerebral blood flow and infarct volume in experimental focal stroke

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Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

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7 January 2021

Cerebral hypoxia: some new approaches and unanswered questions

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7 January 2021

Reduction of central nervous system ischemic injury by monoclonal antibody to intercellular adhesion molecule

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7 January 2021

Impaired microvascular filling after focal cerebral ischemia in the monkey: Modification by treatment

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7 January 2021

Regional cerebral metabolites, blood flow, plasma volume, and mean transit time in total cerebral ischemia in the rat.

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7 January 2021

Experimental acute thrombotic stroke in baboons

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7 January 2021

Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons

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7 January 2021

Cerebral endothelial microvilli: formation following global forebrain ischemia

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7 January 2021

Histopathological and hemodynamic consequences of complete versus incomplete ischemia in the rat.

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7 January 2021

Autoregulation of cerebral blood flow in experimental focal brain ischemia

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7 January 2021

Continuous measurement of cerebral cortical blood flow by laser-Doppler flowmetry in a rat stroke model

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7 January 2021

Pre- and post-treatment with MK-801 but not pretreatment alone reduces neocortical damage after focal cerebral ischemia in the rat.

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7 January 2021

Three-dimensional reconstruction of the rat brain cortical microcirculation in vivo

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7 January 2021

In-vivo confocal scanning laser microscopy of the cerebral microcirculation

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7 January 2021

Protein synthesis and protein phosphorylation during heat stress, recovery, and adaptation

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7 January 2021

Decrease in perfusion of cerebral capillaries during incomplete ischemia and reperfusion

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7 January 2021

Excitatory amino acid receptors, neural membrane phospholipid metabolism and neurological disorders

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7 January 2021

Neutrophil-endothelial cell interaction in critical illness

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7 January 2021

Impaired perfusion following cerebrovascular stasis. A review

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7 January 2021

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

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7 January 2021

The effects of extracellular acidosis on neurons and glia in vitro

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7 January 2021

Granulocyte adhesion, deformability, and superoxide formation in acute stroke

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7 January 2021

Delayed hypoperfusion after incomplete forebrain ischemia in the rat. The role of polymorphonuclear leukocytes

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7 January 2021

Extracellular Adenosine, Inosine, Hypoxanthine, and Xanthine in Relation to Tissue Nucleotides and Purines in Rat Striatum During Transient Ischemia

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7 January 2021

Central nervous system trauma and stroke. II. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation

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7 January 2021

Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period

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7 January 2021

Oxygen toxicity, oxygen radicals, transition metals and disease

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7 January 2021

Fluorescent markers for hypoxic cells: a study of nitroaromatic compounds, with fluorescent heterocyclic side chains, that undergo bioreductive binding

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7 January 2021

Treatment of experimental cerebral ischemia

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7 January 2021

Multiparametric imaging of blood flow and metabolism after middle cerebral artery occlusion in cats

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7 January 2021

Effect of intravascular platelet aggregation on blood recirculation following prolonged ischemia of the cat brain

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7 January 2021

The mechanism of protein kinase C activation

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7 January 2021

Liposome-entrapped superoxide dismutase reduces cerebral infarction in cerebral ischemia in rats

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7 January 2021

Morphometric evaluation of post-ischemic capillary perfusion in selectively vulnerable areas of gerbil brain

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7 January 2021

Brain edema during ischemia and after restoration of blood flow. Measurement of water, sodium, potassium content and plasma protein permeability

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7 January 2021

Continuous nimodipine treatment attenuates cortical infarction in rats subjected to 24 hours of focal cerebral ischemia.

1 reference

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7 January 2021

Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters

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7 January 2021

Local cerebral blood flow in the recovery period following complete cerebral ischemia in the rat.

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7 January 2021

Temporal thresholds for neocortical infarction in rats subjected to reversible focal cerebral ischemia

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7 January 2021

Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase

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7 January 2021

Protein synthesis in the cat brain after prolonged cerebral ischemia

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7 January 2021

The role of hydrostatic pressure in ischemic brain edema

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7 January 2021

Vulnerability of cultured cortical neurons to damage by excitotoxins: differential susceptibility of neurons containing NADPH-diaphorase.

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7 January 2021

Hydrogen ions kill brain at concentrations reached in ischemia

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7 January 2021

The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion

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7 January 2021

No correlation between cerebral blood flow and neurologic recovery after reversible total cerebral ischemia in the dog.

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7 January 2021

Cell swelling. A factor in ischemic tissue injury

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7 January 2021

Inhibition of neurogenic vasodilatation and plasma extravasation by substance P antagonists, somatostatin and [D-Met2, Pro5]enkephalinamide

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7 January 2021

Delayed postischemic hypoperfusion: A potentially damaging consequence of stroke

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7 January 2021

Oxypurinol reduces focal ischemic brain injury in the rat.

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7 January 2021

Platelet-activating factor in stroke and brain injury

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7 January 2021

Rapid adhesive responses of endothelial cells and of neutrophils induced by leukotriene B4 are mediated by leucocytic adhesion protein CD18

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7 January 2021

Microcirculatory obstruction in focal cerebral ischemia: albumin and erythrocyte transit

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7 January 2021

Acidosis-induced ischemic brain damage: are free radicals involved?

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7 January 2021

Total and regional cerebral blood flow measurement with 7-10-, 15-, 25-, and 50-mum microspheres

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7 January 2021

Allopurinol and dimethylthiourea reduce brain infarction following middle cerebral artery occlusion in rats

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7 January 2021

Conjugated superoxide dismutase reduces extent of caudate injury after transient focal ischemia in cats

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2963258-6

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7 January 2021

Blood cell rheology in acute cerebral infarction.

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7 January 2021

Calcium, neuronal hyperexcitability and ischemic injury

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7 January 2021

Intracellular brain pH, indicator tissue perfusion, electroencephalography, and histology in severe and moderate focal cortical ischemia in the rabbit

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7 January 2021

Postischemic canine cerebral blood flow appears to be determined by cerebral metabolic needs

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7 January 2021

Ischemic thresholds of cerebral protein synthesis and energy state following middle cerebral artery occlusion in rat.

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7 January 2021

Effect of pretreatment with the calcium antagonist nimodipine on local cerebral blood flow and histopathology after middle cerebral artery occlusion

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7 January 2021

Functional magnetic resonance imaging in medicine and physiology

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7 January 2021

Further evaluation of polypeptide synthesis in cerebral anoxia, hypoxia and ischemia

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7 January 2021

The regulation of cytosolic calcium in rat brain synaptosomes by sodium-dependent calcium efflux

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7 January 2021

Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion

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7 January 2021

Inositol polyphosphates and neuronal calcium homeostasis

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7 January 2021

Acid-induced death in neurons and glia

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7 January 2021

Ca2+-activated mechanisms in cell killing

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7 January 2021

Effect of recirculation on exacerbation of ischemic vascular lesions in rat brain

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7 January 2021

Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse

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7 January 2021

Platelet accumulation in regions of low blood flow during the postischemic period

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2963258-6

7 January 2021

Protective effect of the glutamate antagonist, MK-801 in focal cerebral ischemia in the cat.

1 reference

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7 January 2021

The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat

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7 January 2021

Oxygen radicals induce human endothelial cells to express GMP-140 and bind neutrophils

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7 January 2021

Excitatory amino acid release from rat hippocampal slices as a consequence of free-radical formation

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7 January 2021

Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage.

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7 January 2021

Edema and vascular permeability in cerebral ischemia: comparison between ischemic neuronal damage and infarction

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7 January 2021

Light and electron microscopic evaluation of hydrogen ion-induced brain necrosis

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7 January 2021

Cerebral intracellular pH by 31P nuclear magnetic resonance spectroscopy

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7 January 2021

Positron emission tomography: human brain function and biochemistry

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7 January 2021

Effect of platelet-activating factor (PAF-acether) and its specific receptor antagonist, BN 52021, on interleukin 1 (IL1) release and synthesis by rat spleen adherent monocytes.

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7 January 2021

What causes infarction in ischemic brain?: The Robert Wartenberg Lecture

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7 January 2021

Peripheral white blood cell count in cerebral ischemic infarction

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7 January 2021

Selective neuronal vulnerability: morphological and molecular characteristics

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7 January 2021

Temporal profile of neuronal damage in a model of transient forebrain ischemia

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https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2963258-6

7 January 2021

Regional cerebral blood flow and glucose metabolism following transient forebrain ischemia

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https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2963258-6

7 January 2021

Skeletal muscle function after ischemia: "no reflow" versus reperfusion injury

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7 January 2021

Electrical stimulation of cerebellar fastigial nucleus reduces ischemic infarction elicited by middle cerebral artery occlusion in rat.

1 reference

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7 January 2021

Noninvasive determination of regional cerebral blood flow in rats using dynamic imaging with Gd(DTPA)

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7 January 2021

Early changes in blood brain barrier permeability to small molecules after transient cerebral ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2963258-6

7 January 2021

Calcium antagonists reduce the extent of infarction in rat middle cerebral artery occlusion model as determined by quantitative magnetic resonance imaging

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2963258-6

7 January 2021

Phospholipid-sensitive Ca2+-dependent protein kinase phosphorylates the beta subunit of eukaryotic initiation factor 2 (eIF-2)

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7 January 2021

Experimental brain infarcts in cats. II. Ischemic brain edema.

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https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2963258-6

7 January 2021

Leucocyte depletion does not affect post-ischaemic nerve cell damage in the rat

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https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2963258-6

7 January 2021

Flow control among microvessels coordinated by intercellular conduction.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2963258-6

7 January 2021

Recirculation model following MCA occlusion in rats. Cerebral blood flow, cerebrovascular permeability, and brain edema

1 reference

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7 January 2021

Cell damage in the brain: a speculative synthesis

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7 January 2021

Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: a unifying hypothesis

1 reference

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7 January 2021

Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

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7 January 2021

Neutrophils are not necessary for ischemia-reperfusion lung injury

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https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2963258-6

7 January 2021

Dextromethorphan alters cerebral blood flow and protects against cerebral injury following focal ischemia

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https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2963258-6

7 January 2021

In vivo evaluation of microcirculation by coherent light scattering

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2963258-6

7 January 2021

The cortical ischaemic penumbra associated with occlusion of the middle cerebral artery in the cat: 1. Topography of changes in blood flow, potassium ion activity, and EEG

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7 January 2021

Umbelliferone as an Intracellular pH-sensitive fluorescent indicator and blood-brain barrier probe: instrumentation, calibration, and analysis

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7 January 2021

The effects of 5-minute ischemia in Mongolian gerbils: I. Blood-brain barrier, cerebral blood flow, and local cerebral glucose utilization changes

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7 January 2021

Monoclonal leukocyte antibody does not decrease the injury of transient focal cerebral ischemia in cats

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7 January 2021

The effects of a competitive NMDA receptor antagonist (CGS-19755) on cerebral blood flow and pH in focal ischemia

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7 January 2021

Modulation of the N-methyl-D-aspartate channel by extracellular H+

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7 January 2021

Oxygen radical mechanisms of brain injury following ischemia and reperfusion

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7 January 2021

Are blood platelets involved in the pathogenesis of ischemic brain edema in gerbils?

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7 January 2021

Focal cerebral ischemia in the rat: topography of hemodynamic and histopathological changes

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7 January 2021

Role of platelet-activating factor in aggregation of leukocytes and platelets in cerebral ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2963258-6

7 January 2021

In vivo Fluorometric Measurement of Changes in Cytosolic Free Calcium from the Cat Cortex during Anoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2963258-6

7 January 2021

Leukocyte involvement in cerebral ischemia and reperfusion injury

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2963258-6

7 January 2021

Confocal laser microscopy to study microcirculation on the rat brain surface in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2963258-6

7 January 2021

Imaging of leukocytes within the rat brain cortex in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2963258-6

7 January 2021

Ischemic injury in the brain. Role of oxygen radical-mediated processes

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2963258-6

7 January 2021

Tissue destruction by neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2963258-6

7 January 2021

Hemorheology of the cerebral circulation in stroke

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2963258-6

7 January 2021

10.1016/S0079-6123(08)63258-6

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1 reference