Genetic manipulation of antitumor-agent biosynthesis to produce novel drugs (Q40834190)

24 September 2017

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title

Genetic manipulation of antitumor-agent biosynthesis to produce novel drugs (English)

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24 September 2017

Salas JA

1

1 reference

PubMed ID

9830156

24 September 2017

Méndez C

series ordinal

2

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24 September 2017

1 November 1998

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24 September 2017

Trends in Biotechnology

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24 September 2017

16

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24 September 2017

11

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24 September 2017

475-482

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ABC Transporters: From Microorganisms to Man

24 September 2017

1 reference

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New pharmaceuticals from marine organisms

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Molecular genetics of polyketides and its comparison to fatty acid biosynthesis

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Polyketide synthesis: prospects for hybrid antibiotics

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Polyketide synthase gene manipulation: a structure-function approach in engineering novel antibiotics

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Pathway engineering in secondary metabolite-producing actinomycetes

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Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria

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Cloning and heterologous expression of a gene cluster for the biosynthesis of tetracenomycin C, the anthracycline antitumor antibiotic of Streptomyces glaucescens

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Multigene families for anthracycline antibiotic production in Streptomyces peucetius

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Cloning and expression of daunorubicin biosynthesis genes from Streptomyces peucetius and S. peucetius subsp. caesius

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Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius

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Cloning and characterization of the Streptomyces peucetius dnrQS genes encoding a daunosamine biosynthesis enzyme and a glycosyl transferase involved in daunorubicin biosynthesis

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A bacterial analog of the mdr gene of mammalian tumor cells is present in Streptomyces peucetius, the producer of daunorubicin and doxorubicin

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Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces sp. strain C5.

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Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5.

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Cloning and characterization of a polyketide synthase gene from Streptomyces fradiae Tü2717, which carries the genes for biosynthesis of the angucycline antibiotic urdamycin A and a gene probably involved in its oxygenation

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Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents

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Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin

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Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin

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Gene organization in the bleomycin-resistance region of the producer organism Streptomyces verticillus

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Cloning and analysis of a locus (mcr) involved in mitomycin C resistance in Streptomyces lavendulae

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Characterization of a mitomycin-binding drug resistance mechanism from the producing organism, Streptomyces lavendulae

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BMS-192548, a tetracyclic binding inhibitor of neuropeptide Y receptors, from Aspergillus niger WB2346. II. Physico-chemical properties and structural characterization.

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Identification of Two Genes from Streptomyces argillaceus Encoding Glycosyltransferases Involved in Transfer of a Disaccharide during Biosynthesis of the Antitumor Drug Mithramycin

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Homology between Streptomyces genes coding for synthesis of different polyketides used to clone antibiotic biosynthetic genes

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Generation of polyketide libraries via combinatorial biosynthesis

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Identification of Streptomyces olivaceus Tü 2353 genes involved in the production of the polyketide elloramycin

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Tetracenomycin M, a Novel Genetically Engineered Tetracenomycin Resulting from a Combination of Mithramycin and Tetracenomycin Biosynthetic Genes

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Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius

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How antibiotic-producing organisms avoid suicide

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ABC transporters in antibiotic-producing actinomycetes

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The Streptomyces peucetius drrC gene encodes a UvrA-like protein involved in daunorubicin resistance and production

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Bleomycin resistance conferred by a drug-binding protein

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Inactivation of bleomycin by anN-acetyltransferase in the bleomycin-producing strainStreptomyces verticillus

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Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.

1 reference

9 March 2024

https://opencitations.net/index/api/v1/citations/10.1002/J.1460-2075.1989.TB08414.X

Identifiers

DOI

10.1016/S0167-7799(98)01198-6

1 reference

24 September 2017

1 reference

PubMed ID

9830156