Determinants of glucose toxicity and its reversibility in the pancreatic islet beta-cell line, HIT-T15. (Q40846007)

24 September 2017

Determinants of glucose toxicity and its reversibility in the pancreatic islet beta-cell line, HIT-T15. (English)

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24 September 2017

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Gleason CE

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24 September 2017

Gonzalez M

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2

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24 September 2017

Harmon JS

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3

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24 September 2017

Robertson RP

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4

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24 September 2017

1 November 2000

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American Journal of Physiology - Endocrinology and Metabolism

24 September 2017

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24 September 2017

279

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24 September 2017

5

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24 September 2017

E997-1002

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Relationships Between Fasting Plasma Glucose Levels and Insulin Secretion During Intravenous Glucose Tolerance Tests

24 September 2017

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https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Prolonged exposure of pancreatic islets isolated from "pre-diabetic" non-obese diabetic mice to a high glucose concentration does not impair beta-cell function

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Pancreatic B-cell dysfunction and glucose toxicity in non-insulin-dependent diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

The desensitization of normal B-cells to glucose in vitro is transient and not related to high glucose levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Involvement of the cytoskeleton in the steroidogenic response of frog adrenal glands to angiotensin II, acetylcholine and serotonin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Reconstitution of glucotoxic HIT-T15 cells with somatostatin transcription factor-1 partially restores insulin promoter activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Monolayer Culture of Adult Rat Pancreatic Islets on Extracellular Matrix: Modulation of B-Cell Function by Chronic Exposure to High Glucose*

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Differentiation between glucose-induced desensitization of insulin secretion and beta-cell exhaustion in the HIT-T15 cell line

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Increase in insulin response after treatment of overt maturity-onset diabetes is independent of the mode of treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Beta-cell hypersensitivity for glucose precedes loss of glucose-induced insulin secretion in 90% pancreatectomized rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Shared biochemical properties of glucotoxicity and lipotoxicity in islets decrease citrate synthase activity and increase phosphofructokinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Pancreatic beta-cell-specific repression of insulin gene transcription by CCAAT/enhancer-binding protein beta. Inhibitory interactions with basic helix-loop-helix transcription factor E47.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Glucose rapidly and reversibly decreases INS-1 cell insulin gene transcription via decrements in STF-1 and C1 activator transcription factor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Coupling of beta-cell desensitization by hyperglycemia to excessive stimulation and circulating insulin in glucose-infused rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Long exposure to high glucose concentration impairs the responsive expression of gamma-glutamylcysteine synthetase by interleukin-1beta and tumor necrosis factor-alpha in mouse endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

Insulin secretion and cAMP metabolism in HIT cells. Reciprocal and serial passage-dependent relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.2000.279.5.E997

10.1152/AJPENDO.2000.279.5.E997

21 January 2018

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