The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT). (Q40848135)

24 September 2017

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title

The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT). (English)

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24 September 2017

R J Knox

1

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24 September 2017

F Friedlos

series ordinal

2

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24 September 2017

M P Boland

series ordinal

3

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24 September 2017

publication date

1 June 1993

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Cancer and Metastasis Reviews

24 September 2017

published in

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24 September 2017

volume

12

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24 September 2017

issue

2

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24 September 2017

page(s)

195-212

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Identification of novel reduced pyridinium derivatives as synthetic co-factors for the enzyme DT diaphorase (NAD(P)H dehydrogenase (quinone), EC 1.6.99.2)

24 September 2017

cites work

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12 December 2020

The effect of alkylating agents on adenosine 3′,5′-monophosphate metabolism in walker carcinoma

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12 December 2020

The properties of total adducts and interstrand crosslinks in the DNA of cells treated with CB 1954. Exceptional frequency and stability of the crosslink

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12 December 2020

Antibody-directed enzyme/prodrug therapy (ADEPT).

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12 December 2020

Antibody directed enzymes revive anti-cancer prodrugs concept

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12 December 2020

Anti-tumor effects of antibody-alkaline phosphatase conjugates in combination with etoposide phosphate

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12 December 2020

CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells

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12 December 2020

The Walker 256 carcinoma: a cell type inherently sensitive only to those difunctional agents that can form DNA interstrand crosslinks

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12 December 2020

Bioactivation of CB 1954: reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand crosslinking species

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12 December 2020

Radiosensitizing and Cytotoxicity Studies with CB 1954 (2,4-Dinitro-5-Aziridinylbenzamide)

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12 December 2020

A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells

1 reference

12 December 2020

The metabolism of the anti-tumour agent 5-(1-aziridinyl)-2,4-dinitrobenzamide (CB 1954)

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12 December 2020

The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--I. Purification and properties of a nitroreductase enzyme from Escherichia coli--a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT).

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12 December 2020

Activation of prodrugs by targeted enzymes

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12 December 2020

Selective inhibition of ribonucleotide reductase by the monofunctional alkylating agent 5(1-aziridinyl)-2,4-dinitrobenzamide (CB 1954)

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12 December 2020

A cytotoxic agent can be generated selectively at cancer sites

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12 December 2020

Regulation of glutathione transferase and DT-diaphorase mRNAs in persistent hepatocyte nodules during chemical hepatocarcinogenesis

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12 December 2020

"Effect of standard chemotherapeutic agents on human tumour cell lines "in vitro"

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12 December 2020

Cell hybridization study of resistance to alkylating agents.

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12 December 2020

DT-diaphorase and cancer chemotherapy

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12 December 2020

Studies on the protection by imidazoles against the cytotoxicity of the antitumour alkylating agents melphalan and CB 1954

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12 December 2020

Tumour-growth inhibitory nitrophenylaziridines and related compounds: Structure-activity relationships. II

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12 December 2020

Alkylating analogues of the tumour inhibitor 5-aziridino-2,4-dinitrobenzamide

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12 December 2020

The toxicity and mutagenicity of the anti-tumour drug 5-aziridino-2,4-dinitrobenzamide (CB1954) is greatly reduced in a nitroreductase-deficient strain of E. coli.

1 reference

12 December 2020

Caffeine, aminoimidazolecarboxamide and dicoumarol, inhibitors of NAD(P)H dehydrogenase (quinone) (DT diaphorase), prevent both the cytotoxicity and DNA interstrand crosslinking produced by 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) in Walker

1 reference

12 December 2020

The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)

1 reference

12 December 2020

The differential response of resistant and sensitive strains of Escherichia coli to the cytotoxic effects of 5-aziridino-2,4-dinitrobenzamide (CB1954).

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12 December 2020

Cytotoxic agents: III, derivatives of ethyleneimine

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12 December 2020

Cyclic nucleotide metabolism in walker carcinoma cells resistant to alkylating agents

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12 December 2020

Comparative effects of alkylating agents and other anti-tumour agents on the intracellular level of adenosine 3′,5′-monophosphate in Walker carcinoma

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12 December 2020

Human DT-diaphorase, a potential cancer protecting enzyme. Its purification from abdominal adipose tissue

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12 December 2020

DT-diaphorase in morbidly obese patients

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12 December 2020

The Sensitivity to Chemotherapeutic Agents of a Rat Tumour Grown in Immunosuppressed Mice

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12 December 2020

The First Bagshawe lecture. Towards generating cytotoxic agents at cancer sites

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12 December 2020

2,4-dinitro-5-ethyleneiminobenzamide (CB 1954): a potent and selective inhibitor of the growth of the Walker carcinoma 256.

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12 December 2020

CB 1954 revisited. I. Disposition kinetics and metabolism

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12 December 2020

The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase

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12 December 2020

Alterations in adenosine 3′,5′-monophosphate-binding protein in Walker carcinoma cells sensitive or resistant to alkylating agents

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12 December 2020

Antibody-penicillin-V-amidase conjugates kill antigen-positive tumor cells when combined with doxorubicin phenoxyacetamide

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12 December 2020

Use of quinones in brain-tumor therapy: preliminary results of preclinical laboratory investigations

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12 December 2020

The effect of monofunctional or difunctional platinum adducts and of various other associated DNA damage on the expression of transfected DNA in mammalian cell lines sensitive or resistant to difunctional agents.

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12 December 2020

Tumour-growth inhibitorynitrofphenylaziridines and related compounds structure-activity relationships

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12 December 2020

Studies on the mechanism of action of 5-aziridinyl-2, 4-dinitrobenzamide in tumor cells

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12 December 2020

Quantitative estimation of cisplatin-induced DNA interstrand cross-links and their repair in mammalian cells: relationship to toxicity

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12 December 2020

CB 1954 revisited. II. Toxicity and antitumour activity

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12 December 2020

Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16

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12 December 2020

Potentiation of CB 1954 cytotoxicity by reduced pyridine nucleotides in human tumour cells by stimulation of DT diaphorase activity

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12 December 2020

Metabolism of NAD(P)H by blood components. Relevance to bioreductively activated prodrugs in a targeted enzyme therapy system

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12 December 2020

The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide)

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12 December 2020

Response of human tumours 'in vitro' to CB-1954 (5-aziridinyl-2, 4-dinitrobenzamide)

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12 December 2020

Chemopotentiation by CB 1954: the importance of postincubations and the possible involvement of poly(ADP-ribosylation)

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12 December 2020

Studies on the reversal of the selective antitumour effect of the aziridinyl derivative cb 1954 by 4-amino-5-imidazolecarboxamide

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12 December 2020

Studies on the mechanism of action of 5-aziridinyl-2,4-dinitrobenzamide (CB 1954), a selective inhibitor of the walker tumour

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12 December 2020

Radiosensitization by the 2,4-dinitro-5-aziridinyl benzamide CB 1954: a structure/activity study.

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12 December 2020

The anticancer enzyme DT diaphorase is induced selectively in liver during ascites hepatoma growth

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12 December 2020

Toxicity of the selective antitumor agent 5-aziridino-2,4-dinitrobenzamide in the rat

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12 December 2020

The use of the D-T diaphorase for the detection of foci of early neoplastic transformation in rat liver

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12 December 2020

Biochemical and quantitative histochemical study of reduced pyridine nucleotide dehydrogenation by human colonic carcinomas

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12 December 2020

Inhibition of cyclic 3′,5′-nucleotide phosphodiesterase—a possible mechanism of action of bifunctional alkylating agents

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12 December 2020

Protection against the effects of the antitumour agent CB 1954 by certain imidazoles and related compounds

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12 December 2020

Identifiers

DOI

10.1007/BF00689810

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Dimensions Publication ID

24 September 2017

1030870237

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