DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C. (Q40848147)

24 September 2017

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title

DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C. (English)

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24 September 2017

D Ross

1

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24 September 2017

D Siegel

2

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24 September 2017

H Beall

3

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24 September 2017

A S Prakash

4

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24 September 2017

R T Mulcahy

5

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24 September 2017

N W Gibson

6

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24 September 2017

1 June 1993

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Cancer and Metastasis Reviews

24 September 2017

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24 September 2017

12

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24 September 2017

2

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24 September 2017

83-101

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https://scigraph.springernature.com/pub.10.1007/bf00689803

24 September 2017

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cites work

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12 December 2020

Mitomycin C is not metabolized by but is an inhibitor of human kidney NAD(P)H: (quinone-acceptor)oxidoreductase

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12 December 2020

Naturally occurring quinones as potential bioreductive alkylating agents

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12 December 2020

Reductive activation of mitomycin C

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12 December 2020

NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity

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12 December 2020

Role of NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase) in activation of mitomycin C under hypoxia

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12 December 2020

Metabolic activation of mitomycin C by liver microsomes and nuclei

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12 December 2020

Reductive metabolism and alkylating activity of mitomycin C induced by rat liver microsomes

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12 December 2020

Modification of the metabolism and cytotoxicity of bioreductive alkylating agents by dicoumarol in aerobic and hypoxic murine tumor cells

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12 December 2020

Enhancement of mitomycin C cytotoxicity to hypoxic tumor cells by dicoumarol in vivo and in vitro

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12 December 2020

Metabolism of diaziquone by NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase): role in diaziquone-induced DNA damage and cytotoxicity in human colon carcinoma cells

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12 December 2020

DT-diaphorase as a quinone reductase: a cellular control device against semiquinone and superoxide radical formation

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Therapeutic attack of hypoxic cells of solid tumors: presidential address

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The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins.

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Genomic sequence and expression of a cloned human carbonyl reductase gene with daunorubicin reductase activity

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DNA crosslinking and sequence selectivity of aziridinylbenzoquinones: a unique reaction at 5'-GC-3' sequences with 2,5-diaziridinyl-1,4-benzoquinone upon reduction

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12 December 2020

DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas

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12 December 2020

Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase

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12 December 2020

Isolation of Chinese hamster ovary cell mutants deficient in excision repair and mitomycin C bioactivation

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12 December 2020

Bioreductive activation of mitomycin C by DT-diaphorase

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12 December 2020

Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin Cł

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Mitomycin C in multiple superficial bladder tumors: short-term therapy, long-term results

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Alkylation of DNA by C-10 of 2,7-diaminomitosene

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12 December 2020

Studies on the mechanism of resistance to mitomycin C and porfiromycin in a human cell strain derived from a cancer-prone individual

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4'-Epidoxorubicin versus Mitomycin C Intravesical Chemoprophylaxis of Superficial Bladder Cancer

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Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin

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12 December 2020

pH dependence of mitomycin C-induced cross-linking activity in EMT6 tumor cells

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12 December 2020

Decreased NADPH:cytochrome P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions

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Redox cycling of potential antitumor aziridinyl quinones

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Cell-specific metabolism in mouse bone marrow stroma: studies of activation and detoxification of benzene metabolites

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Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase

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Cytosolic NAD(P)H:(quinone-acceptor)oxidoreductase in human normal and tumor tissue: effects of cigarette smoking and alcohol

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Characterization of L5178Y murine lymphoblasts resistant to quinone antitumor agents

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Use of quinones in brain-tumor therapy: preliminary results of preclinical laboratory investigations.

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MITOMYCINS AND PORFIROMYCIN: CHEMICAL MECHANISM OF ACTIVATION AND CROSS-LINKING OF DNA.

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Deficient activation by a human cell strain leads to mitomycin resistance under aerobic but not hypoxic conditions

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DNA cross-linking by intermediates in the mitomycin activation cascade

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12 December 2020

Alteration in DNA cross-linking and sequence selectivity of a series of aziridinylbenzoquinones after enzymatic reduction by DT-diaphorase

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12 December 2020

DT-diaphorase: questionable role in mitomycin C resistance, but a target for novel bioreductive drugs?

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Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16

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Bone marrow stromal cell bioactivation and detoxification of the benzene metabolite hydroquinone: comparison of macrophages and fibroblastoid cells.

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12 December 2020

Autocatalytic quinone methide formation from mitomycin c.

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12 December 2020

Increased sensitivity of quinone resistant cells to mitomycin C.

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12 December 2020

Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells

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12 December 2020

Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells

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12 December 2020

Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells.

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12 December 2020

Chinese hamster ovary cell lines resistant to mitomycin C under aerobic but not hypoxic conditions are deficient in DT-diaphorase

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12 December 2020

Bioactivation of Mitomycin C by Xanthine Dehydrogenase From EMT6 Mouse Mammary Carcinoma Tumors

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12 December 2020

The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide)

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12 December 2020

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12 December 2020

Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element

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12 December 2020

Activation of mitomycin C by NADPH:cytochrome P-450 reductase

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12 December 2020

A MOLECULAR MECHANISM OF MITOMYCIN ACTION: LINKING OF COMPLEMENTARY DNA STRANDS

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12 December 2020

The sensitivity of human tumour cells to quinone bioreductive drugs: what role for DT-diaphorase?

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12 December 2020

Differential cytotoxicity of diaziquone toward Chinese hamster ovary cells under hypoxic and aerobic exposure conditions

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12 December 2020

The cellular response to induction of the p21 c-Ha-ras oncoprotein includes stimulation of jun gene expression

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12 December 2020

High levels of expression of the NAD(P)H:Quinone oxidoreductase (NQO1) gene in tumor cells compared to normal cells of the same origin

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12 December 2020

Structure-activity relationships for DT-diaphorase reduction of hypoxic cell directed agents: indoloquinones and diaziridinyl benzoquinones

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12 December 2020

Two structurally related diaziridinylbenzoquinones preferentially cross-link DNA at different sites upon reduction with DT-diaphorase

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12 December 2020

The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells

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12 December 2020

Relationship between DT-diaphorase-mediated metabolism of a series of aziridinylbenzoquinones and DNA damage and cytotoxicity.

1 reference

12 December 2020

Role of cytosolic NAD(P)H-quinone oxidoreductase and alcohol dehydrogenase in the reduction of p-nitrosophenol following chronic ethanol ingestion

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12 December 2020

Trial of the combination of mitomycin, vindesine, and cisplatin in patients with advanced non-small cell lung cancer

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12 December 2020

Porfiromycin as a bioreductive alkylating agent with selective toxicity to hypoxic EMT6 tumor cells in vivo and in vitro.

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12 December 2020

Identifiers

DOI

10.1007/BF00689803

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Dimensions Publication ID

24 September 2017

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