Determinants of ligand binding specificity in the glial cell line-derived neurotrophic factor family receptor alpha S. (Q40851328)

24 September 2017

Determinants of ligand binding specificity in the glial cell line-derived neurotrophic factor family receptor alpha S. (English)

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24 September 2017

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Scott RP

1

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PubMed ID

11018032

24 September 2017

Ibanez CF

series ordinal

2

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PubMed ID

11018032

24 September 2017

language of work or name

English

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publication date

1 January 2001

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Journal of Biological Chemistry

24 September 2017

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24 September 2017

276

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24 September 2017

2

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24 September 2017

1450-1458

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A structural superfamily of growth factors containing a cystine knot motif

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Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor

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Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor

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GDNF family neurotrophic factor signaling: four masters, one servant?

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Regulation of cell fate decision of undifferentiated spermatogonia by GDNF.

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GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons

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Neurturin, a relative of glial-cell-line-derived neurotrophic factor

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Persephin, a novel neurotrophic factor related to GDNF and neurturin

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Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex

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Enovin, a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. Existence and tissue-specific expression of different splice variants

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In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin

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Functional receptor for GDNF encoded by the c-ret proto-oncogene

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GDNF signalling through the Ret receptor tyrosine kinase

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Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase

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Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis

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GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF

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Characterization of a multicomponent receptor for GDNF.

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Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins

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Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase

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Distinct structural elements in GDNF mediate binding to GFRalpha1 and activation of the GFRalpha1-c-Ret receptor complex

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Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells

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GDNF triggers a novel ret-independent Src kinase family-coupled signaling via a GPI-linked GDNF receptor alpha1.

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GFRalpha-4, a new GDNF family receptor

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Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons

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Rapid and efficient site-specific mutagenesis without phenotypic selection

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Combining evolutionary information and neural networks to predict protein secondary structure

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TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.

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Identification of mammalian GFRalpha-2 splice isoforms

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Expression and alternative splicing of mouse Gfra4 suggest roles in endocrine cell development

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Mammalian GFRalpha -4, a divergent member of the GFRalpha family of coreceptors for glial cell line-derived neurotrophic factor family ligands, is a receptor for the neurotrophic factor persephin

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N-Glycans mediate the apical sorting of a GPI-anchored, raft-associated protein in Madin-Darby canine kidney cells

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Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC

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Specificity determinants in neurotrophin-3 and design of nerve growth factor-based trkC agonists by changing central beta-strand bundle residues to their neurotrophin-3 analogs.

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Functional mapping of receptor specificity domains of glial cell line-derived neurotrophic factor (GDNF) family ligands and production of GFRalpha1 RET-specific agonists

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21 January 2018

Identifiers

DOI

10.1074/JBC.M006157200

1 reference

24 September 2017

1 reference

PubMed ID

11018032