Pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus: candidates for a signal transmitter defect causing insulin resistance of the skeletal muscle (Q40852707)

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scientific article published on March 1993

Language	Label	Description	Also known as
English	Pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus: candidates for a signal transmitter defect causing insulin resistance of the skeletal muscle	scientific article published on March 1993

Statements

scholarly article

1 reference

Europe PubMed Central

24 September 2017

1 reference

Europe PubMed Central

Pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus: candidates for a signal transmitter defect causing insulin resistance of the skeletal muscle (English)

1 reference

Europe PubMed Central

24 September 2017

1 reference

based on heuristic

inferred from title

insulin resistance

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based on heuristic

inferred from title

Hans-Ulrich Häring

1

object named as

H U Häring

1 reference

Europe PubMed Central

24 September 2017

author name string

H Mehnert

2

1 reference

Europe PubMed Central

24 September 2017

language of work or name

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based on heuristic

inferred from title

publication date

1 March 1993

1 reference

Europe PubMed Central

24 September 2017

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Europe PubMed Central

24 September 2017

36

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Europe PubMed Central

24 September 2017

3

1 reference

Europe PubMed Central

24 September 2017

176-182

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Europe PubMed Central

24 September 2017

https://scigraph.springernature.com/pub.10.1007/bf00399946

0 references

Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents.

1 reference

https://api.crossref.org/works/10.1007%2FBF00399946

21 January 2018

Further evidence for a two-step model of glucose-transport regulation. Inositol phosphate-oligosaccharides regulate glucose-carrier activity

1 reference

https://api.crossref.org/works/10.1007%2FBF00399946

21 January 2018

A defective intramolecular autoactivation cascade may cause the reduced kinase activity of the skeletal muscle insulin receptor from patients with non-insulin-dependent diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective insulin receptor tyrosine kinase in human skeletal muscle in obesity and type 2 (non-insulin-dependent) diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-sensitive tyrosine kinase: relationship with in vivo insulin action in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in insulin-receptor gene in insulin-resistant patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperinsulinemia in a population at high risk for non-insulin-dependent diabetes mellitus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blood pressure, insulin, and glycemia in nondiabetic subjects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired activation of glycogen synthase in people at increased risk for developing NIDDM

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of elevated fasting C-peptide level and increased intra-abdominal fat distribution with development of NIDDM in Japanese-American men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal insulin-receptor cDNA sequence in Pima Indians with NIDDM

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin receptor isotype expression correlates with risk of non-insulin-dependent diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired glucose tolerance as a disorder of insulin action. Longitudinal and cross-sectional studies in Pima Indians.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mediators of postreceptor action of insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Hypertension and diabetes mellitus]

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of impaired muscle glucose clearance to reduced postabsorptive systemic glucose clearance in NIDDM.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Restoration of insulin responsiveness in skeletal muscle of morbidly obese patients after weight loss. Effect on muscle glucose transport and glucose transporter GLUT4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired insulin-stimulated muscle glycogen synthase activation in vivo in man is related to low fasting glycogen synthase phosphatase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The two isotypes of the human insulin receptor (HIR-A and HIR-B) follow different internalization kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered expression of the two naturally occurring human insulin receptor variants in isolated adipocytes of non-insulin-dependent diabetes mellitus patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of phosphatidylinositol-3-kinase by insulin is mediated by both A and B human insulin receptor types

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin resistance in type 2 (non-insulin-dependent) diabetic patients and their relatives is not associated with a defect in the expression of the insulin-responsive glucose transporter (GLUT-4) gene in human skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin receptor kinase defects as a possible cause of cellular insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal Regulation of Protein Tyrosine Phosphatase Activities in Skeletal Muscle of Insulin-Resistant Humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular biology of mammalian glucose transporters

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective insulin response of phosphorylase phosphatase in insulin-resistant humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin resistance is associated with reduced fasting and insulin-stimulated glycogen synthase phosphatase activity in human skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-mediated increase in glucose 1,6-bisphosphate is attenuated in skeletal muscle of insulin-resistant man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of insulin and insulin-like growth factors I and II on phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate breakdown in liver from humans with and without type II diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of insulin regulatable glucose transporters in skeletal muscle from type 2 (non-insulin-dependent) diabetic patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functionally distinct insulin receptors generated by tissue-specific alternative splicing

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperinsulinemia. A link between hypertension obesity and glucose intolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of mutations in insulin-receptor gene in NIDDM patients by analysis of single-stranded conformation polymorphisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low urinary chiro-inositol excretion in non-insulin-dependent diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different ligand affinities of the two human insulin receptor splice variants are reflected in parallel changes in sensitivity for insulin action

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin resistance in essential hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective insulin response of cyclic adenosine monophosphate-dependent protein kinase in insulin-resistant humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alternatively spliced variants of the insulin receptor protein. Expression in normal and diabetic human tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenesis of NIDDM. A balanced overview

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered expression of insulin receptor types A and B in the skeletal muscle of non-insulin-dependent diabetes mellitus patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of defective insulin-receptor kinase activity in NIDDM. Evidence for two receptor populations

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Skeletal muscle glycogen synthase activity in subjects with non-insulin-dependent diabetes mellitus after glyburide therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asymptomatic diabetes mellitus in normal weight subjects with hypertension. Studies on glucose tolerance, serum insulin and nonesterified fatty acids in essential hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alternative splicing of human insulin receptor messenger RNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma insulin response among Nauruans. Prediction of deterioration in glucose tolerance over 6 yr

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subcellular distribution of GLUT 4 in the skeletal muscle of lean type 2 (non-insulin-dependent) diabetic patients in the basal state

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The insulin receptor: signalling mechanism and contribution to the pathogenesis of insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of phospholipase C activity by insulin is mediated by both isotypes of the human insulin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production of Inhibitor of Insulin-Receptor Tyrosine Kinase in Fibroblasts From Patient With Insulin Resistance and NIDDM

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein phosphorylation and the control of glycogen metabolism in skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NIDDM Associated With Mutation in Tyrosine Kinase Domain of Insulin Receptor Gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct alpha-subunit structures of human insulin receptor A and B variants determine differences in tyrosine kinase activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/8385036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF00399946

1 reference

Europe PubMed Central

24 September 2017

1 reference

Europe PubMed Central

24 September 2017

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