4-Aminoquinolines--past, present, and future: a chemical perspective (Q40866974)

24 September 2017

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title

4-Aminoquinolines--past, present, and future: a chemical perspective (English)

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ORCID Public Data File 2021

24 September 2017

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author name string

O'Neill PM

1

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24 September 2017

Bray PG

2

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24 September 2017

Hawley SR

3

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24 September 2017

Ward SA

4

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24 September 2017

Park BK

5

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24 September 2017

1 January 1998

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Pharmacology & Therapeutics

24 September 2017

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24 September 2017

77

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24 September 2017

29-58

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24 September 2017

1

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The feeding mechanism of avian malarial parasites

24 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

The effect of fluorine substitution on the hepatotoxicity and metabolism of paracetamol in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Further evidence for the interaction of the antimalarial drug amodiaquine with ferriprotoporphyrin IX

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Rapid chloroquine efflux phenotype in both chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum. A correlation of chloroquine sensitivity with energy-dependent drug accumulation.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Relationship of global chloroquine transport and reversal of resistance in Plasmodium falciparum.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Aminoalkylphenols as antimalarials (heterocyclicamino)-alpha-amino-o-cresols; the synthesis of camoquin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

A comparison of the in vitro activities of amodiaquine and desethylamodiaquine against isolates of Plasmodium falciparum.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Ferriprotoporphyrin IX fulfills the criteria for identification as the chloroquine receptor of malaria parasites

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Amodiaquine as a prodrug: importance of metabolite(s) in the antimalarial effect of amodiaquine in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Pitfalls in a Discovery: The Chronicle of Chloroquine *

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

COMPLEX FORMATION BETWEEN CHLOROQUINE AND FERRIHAEMIC ACID IN VITRO, AND ITS EFFECT ON THE ANTIMALARIAL ACTION OF CHLOROQUINE.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

The P-glycoprotein homologues of Plasmodium falciparum: Are they involved in chloroquine resistance?

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

The use of avian malaria for the discovery of drugs effective in the treatment and prevention of human malaria; drugs for causal prophylaxis and radical cure or the chemotherapy of exo-erythrocytic forms.

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https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Commentary. Lysosomotropic agents

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https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Malarial haemozoin/beta-haematin supports haem polymerization in the absence of protein

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Quinoline anti-malarial drugs inhibit spontaneous formation of beta-haematin (malaria pigment).

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

The biochemistry of P-glycoprotein-mediated multidrug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Sequestration of the chloroquine receptor in cell-free preparations of erythrocytes infected with Plasmodium berghei

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Lysis of Plasmodium falciparum by ferriprotoporphyrin IX and a chloroquine-ferriprotoporphyrin IX complex

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

The single dose kinetics of chloroquine and its major metabolite desethylchloroquine in healthy subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Uptake of [3H]chloroquine by drug-sensitive and -resistant strains of the human malaria parasite Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Kinetic modelling of the response of Plasmodium falciparum to chloroquine and its experimental testing in vitro. Implications for mechanism of action of and resistance to the drug

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Current concepts and new ideas on the mechanism of action of quinoline-containing antimalarials

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Quinoline-containing antimalarials—mode of action, drug resistance and its reversal an update with unresolved puzzles

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Kinetic modelling of chloroquine uptake by malaria-infected erythrocytes. Assessment of the factors that may determine drug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Synthesis of some novel amodiaquine analogues as potential antimalarial and antifilarial compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Biochemistry of multidrug resistance mediated by the multidrug transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Effects of chloroquine on Plasmodium knowlesi in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

The mechanism of bioactivation and antigen formation of amodiaquine in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Synthesis and antimalarial activity of amodiaquine analogs

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Clinical features and management of poisoning due to antimalarial drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Mechanism of autoxidation of 5,7-dihydroxytryptamine: effect of fluorine substitution at positions 4 and/or 6.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

A perspective on antimalarial action: effects of weak bases on Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Dichlorquinazine (alpha 4-aminoquinoline) effective in vitro against chloroquine-resistant Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Morphological Effects of Chloroquine on Plasmodium berghei in Mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Drug-protein conjugates—XIV

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Reversal of chloroquine resistance in Plasmodium falciparum by verapamil

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Animal toxicity and pharmacokinetics of hydroxychloroquine sulfate

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

A nuclear magnetic resonance study of the interactions of antimalarial drugs with porphyrins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Amodiaquine induced agranulocytosis and liver damage.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

The effect of fluorine substitution on the metabolism and antimalarial activity of amodiaquine.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

The effect of fluorine substitution on the haemotoxicity of Primaquine

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Synthesis, antimalarial activity, and molecular modeling of tebuquine analogues

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Hemin lyses malaria parasites

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Effects of fluorine substitution on drug metabolism: pharmacological and toxicological implications

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Antihistaminic drugs that reverse chloroquine resistance in Plasmodium falciparum.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Disposition of amopyroquin in rats and rabbits and in vitro activity against Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Synthesis and activity of some antimalarial bisquinolines.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Effect of fluorine substitution on the anodic oxidation of catecholamines and amino acids

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Randomised trial of pyronaridine versus chloroquine for acute uncomplicated falciparum malaria in Africa

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Malarial pigment-dependent error in the estimation of hemoglobin content in Plasmodium falciparum-infected red cells: implications for metabolic and biochemical studies of the erythrocytic phases of malaria.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

GroupBuild: a fragment-based method for de novo drug design

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Antimalarial activity of Mannich bases derived from 4-(7'-bromo-1',5'-naphthyridin-4'-ylamino)phenol and 4-(7'-trifluoromethylquinolin-4'-ylamino)phenol against Plasmodium falciparum in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

The susceptibility of the malarial parasite Plasmodium falciparum to quinoline-containing drugs is correlated to the lipid composition of the infected erythrocyte membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Quinolines; some 4-aminoquinoline derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Localization and characterization of hemoglobin-degrading aspartic proteinases from the malarial parasite Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Chloroquine uptake by Plasmodium falciparum-infected human erythrocytes during in vitro culture and its relationship to chloroquine resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

The quinine-haemin interaction and its relationship to antimalarial activity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Antimalarial interaction with ferriprotoporphyrin IX monomer and its relationship to activity of the blood schizontocides.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Ribonucleic acid from Plasmodium knowlesi before and after chloroquine treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Effectiveness of amodiaquine as treatment for chloroquine-resistant Plasmodium falciparum infections in Kenya

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Molecular genetics of drug resistance in Plasmodium falciparum malaria

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Synthesis, antimalarial activity, and quantitative structure-activity relationships of tebuquine and a series of related 5-[(7-chloro-4-quinolinyl)amino]-3-[(alkylamino)methyl] [1,1'-biphenyl]-2-ols and N omega-oxides

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Pharmacokinetics of intravenous amodiaquine

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Effect of dose size on amodiaquine pharmacokinetics after oral administration.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Chloroquine inhibits the degradation of endocytic vesicles in human malaria parasites

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Effects of chloroquine on the feeding mechanism of the intraerythrocytic human malarial parasite Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Digestion of the host erythrocyte by malaria parasites is the primary target for quinoline-containing antimalarials

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

Lysis of malarial parasites and erythrocytes by ferriprotoporphyrin IX-chloroquine and the inhibition of this effect by proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900084-3

7 January 2021

10.1016/S0163-7258(97)00084-3

Identifiers

DOI

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24 September 2017

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