Targeted drug delivery to tumors: myths, reality and possibility (Q40868797)

24 September 2017

Targeted drug delivery to tumors: myths, reality and possibility (English)

1 reference

24 September 2017

1 reference

You Han Bae

1

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PMCID

3272876

24 September 2017

Kinam Park

series ordinal

2

1 reference

PMCID

3272876

24 September 2017

language of work or name

English

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publication date

6 June 2011

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24 September 2017

8

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Journal of Controlled Release

inferred from page(s)

published in

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24 September 2017

153

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24 September 2017

3

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24 September 2017

198-205

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Targeted toxins in brain tumor therapy

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Hallmarks of Cancer: The Next Generation

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Prevention of metastasis in a 4T1 murine breast cancer model by doxorubicin carried by folate conjugated pH sensitive polymeric micelles

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Cells of origin in cancer

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion

24 September 2017

1 reference

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Delivering nanomedicine to solid tumors

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Relevance of folic acid/polymer ratio in targeted PEG-epirubicin conjugates

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

The effects of particle size and molecular targeting on the intratumoral and subcellular distribution of polymeric nanoparticles

24 September 2017

1 reference

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Monitoring intracellular degradation of exogenous DNA using diffusion properties

24 September 2017

1 reference

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Multiple lineages of human breast cancer stem/progenitor cells identified by profiling with stem cell markers

24 September 2017

1 reference

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Nanosystem drug targeting: Facing up to complex realities

24 September 2017

1 reference

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Intracellular fate of bioresponsive poly(amidoamine)s in vitro and in vivo

24 September 2017

1 reference

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Contemporary pre-clinical development of anticancer agents--what are the optimal preclinical models?

24 September 2017

1 reference

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Heterogeneity in cancer: cancer stem cells versus clonal evolution

24 September 2017

1 reference

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Identification of selective inhibitors of cancer stem cells by high-throughput screening

24 September 2017

1 reference

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Block copolymer micelles for delivery of cancer therapy: transport at the whole body, tissue and cellular levels.

24 September 2017

1 reference

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Dynamics of magnetic lipoplexes studied by single particle tracking in living cells

24 September 2017

1 reference

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Current constructs and targets in clinical development for antibody-based cancer therapy

24 September 2017

1 reference

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Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Drug targeting and tumor heterogeneity

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Efficient tumor targeting of hydroxycamptothecin loaded PEGylated niosomes modified with transferrin

24 September 2017

1 reference

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The origins and evolution of "controlled" drug delivery systems

24 September 2017

1 reference

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New strategies for nucleic acid delivery to conquer cellular and nuclear membranes

24 September 2017

1 reference

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Is tumor growth sustained by rare cancer stem cells or dominant clones?

24 September 2017

1 reference

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The epithelial-mesenchymal transition generates cells with properties of stem cells

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Release of hydrophobic molecules from polymer micelles into cell membranes revealed by Forster resonance energy transfer imaging

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Targeted therapies: a new generation of cancer treatments.

24 September 2017

1 reference

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Recent advances on the molecular mechanisms involved in the drug resistance of cancer cells and novel targeting therapies

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Design of targeted lipid nanocapsules by conjugation of whole antibodies and antibody Fab' fragments

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

The 2007 WHO classification of tumours of the central nervous system

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Hydrotropic polymeric micelles for enhanced paclitaxel solubility: in vitro and in vivo characterization

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Block copolymer micelles as delivery vehicles of hydrophobic drugs: micelle-cell interactions

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Assessment of the integrity of poly(caprolactone)-b-poly(ethylene oxide) micelles under biological conditions: a fluorogenic-based approach

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

50 years of preclinical anticancer drug screening: empirical to target-driven approaches.

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

The human tumor microenvironment: invasive (needle) measurement of oxygen and interstitial fluid pressure

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Combined cancer therapy by micellar-encapsulated drug and ultrasound

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Folate-liposome-mediated antisense oligodeoxynucleotide targeting to cancer cells: evaluation in vitro and in vivo

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Transendothelial transport: the vesicle controversy

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Pegylation: a novel process for modifying pharmacokinetics

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Long-circulating and target-specific nanoparticles: theory to practice

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Effective targeting of solid tumors in patients with locally advanced cancers by radiolabeled pegylated liposomes.

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Chemo-embolization of experimental liver metastases. Part I: distribution of biodegradable microspheres of different sizes in an animal model for the locoregional therapy

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

On the genesis and regulation of cellular heterogeneity in malignant tumors.

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Intraneoplastic diversity

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Tumor heterogeneity: biological implications and therapeutic consequences

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Intratumor immunologic heterogeneity

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Implications of tumor progression on clinical oncology

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Biologic considerations for drug targeting in cancer patients

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Hepatic circulation: potential for therapeutic intervention

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

In vitro and in vivo variation in transferrin receptor expression on a human medulloblastoma cell line

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Effect of arterial administration of high-molecular-weight anticancer agent SMANCS with lipid lymphographic agent on hepatoma: a preliminary report

17 June 2018

1 reference

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Quantitative and qualitative investigation into the impact of focused ultrasound with microbubbles on the triggered release of nanoparticles from vasculature in mouse tumors.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

To PEGylate or not to PEGylate, that is not the question.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Cellular uptake mechanism and intracellular fate of hydrophobically modified glycol chitosan nanoparticles

19 August 2018

1 reference

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Albumin nanoparticles targeted with Apo E enter the CNS by transcytosis and are delivered to neurones.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Paul Ehrlich's magic bullet concept: 100 years of progress.

19 August 2018

1 reference

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Fast release of lipophilic agents from circulating PEG-PDLLA micelles revealed by in vivo forster resonance energy transfer imaging

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3272876

Pharmaceutical nanotechnology: more than size. Ten topics for research

19 August 2018

1 reference

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Key interactions in neocarzinostatin, a protein of the immunoglobulin fold family.

19 August 2018

1 reference

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PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats

19 August 2018

1 reference

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Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows.

19 August 2018

1 reference

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Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.

19 August 2018

1 reference

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Biological diversity in metastatic neoplasms: origins and implications.

19 August 2018

1 reference

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Relationship between antigen density and immunotherapeutic response elicited by monoclonal antibodies against solid tumors.

19 August 2018

1 reference

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CPP–protein constructs induce a population of non-acidic vesicles during trafficking through endo-lysosomal pathway

19 August 2018

1 reference

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Polymer therapeutics: Clinical applications and challenges for development

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Evaluation of the United States Food and Drug Administration-approved scoring and test system of HER-2 protein expression in breast cancer

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12 December 2020

Conjugation of poly(styrene-co-maleic acid) derivatives to the antitumor protein neocarzinostatin: pronounced improvements in pharmacological properties

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12 December 2020

Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft

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Distribution and tissue uptake of poly(ethylene glycol) with different molecular weights after intravenous administration to mice

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Comparison of body distribution of poly(vinyl alcohol) with other water-soluble polymers after intravenous administration

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Endomitotic reduplication mechanisms in ascites tumors of the mouse

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Antibody Targeting of Long-Circulating Lipidic Nanoparticles Does Not Increase Tumor Localization but Does Increase Internalization in Animal Models

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12 December 2020

Does a targeting ligand influence nanoparticle tumor localization or uptake?

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12 December 2020

10.1016/J.JCONREL.2011.06.001

Identifiers

DOI

1 reference

24 September 2017

1 reference

24 September 2017

1 reference

PMCID

3272876