Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system. (Q40874496)

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English	Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system.	scientific article

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7 November 2019

Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system (English)

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7 November 2019

Parkinson's disease

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Anders Björklund

3

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A Bjorklund

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7 November 2019

author name string

D Kirik

1

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7 November 2019

C Rosenblad

2

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7 November 2019

R J Mandel

4

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7 November 2019

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1 June 2000

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7 November 2019

Journal of Neuroscience

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7 November 2019

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7 November 2019

12

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7 November 2019

4686-4700

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7 November 2019

Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GDNF protection against 6-OHDA: time dependence and requirement for protein synthesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral and cellular protection of rat dopaminergic neurons by an adenoviral vector encoding glial cell line-derived neurotrophic factor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GDNF family ligands and receptors are differentially regulated after brain insults in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rate of cell death in parkinsonism indicates active neuropathological process

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective and rapid uptake of adeno-associated virus type 2 in brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopaminergic neurons protected from degeneration by GDNF gene therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of glial cell line-derived neurotrophic factor (GDNF) in the striatum and substantia nigra of the aged Parkinsonian rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Viral gene delivery selectively restores feeding and prevents lethality of dopamine-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial cell line-derived neurotrophic factor prevents death, but not reductions in tyrosine hydroxylase, of injured nigrostriatal neurons in adult rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuron-specific transduction in the rat septohippocampal or nigrostriatal pathway by recombinant adeno-associated virus vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional activity of substantia nigra grafts reinnervating the striatum: neurotransmitter metabolism and [14C]2-deoxy-D-glucose autoradiography

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant adeno-associated viral vector-mediated glial cell line-derived neurotrophic factor gene transfer protects nigral dopamine neurons after onset of progressive degeneration in a rat model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Short-term GDNF treatment provides long-term rescue of lesioned nigral dopaminergic neurons in a rat model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ageing and Parkinson's disease: substantia nigra regional selectivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The "staircase test": a measure of independent forelimb reaching and grasping abilities in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An [18F]dopa-PET and clinical study of the rate of progression in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of glial cell line-derived neurotrophic factor on the nigrostriatal dopamine system in rodents and nonhuman primates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial cell line-derived neurotrophic factor but not transforming growth factor beta 3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term protection of the rat nigrostriatal dopaminergic system by glial cell line-derived neurotrophic factor against 6-hydroxydopamine in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of Adeno-Associated Virus as a General Transduction Vector for Mammalian Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rescuing neurons from trans-synaptic degeneration after brain damage: helpful, harmful, or neutral in recovery of function?

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A commentary on glial cell line-derived neurotrophic factor (GDNF). From a glial secreted molecule to gene therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term restoration of striatal L-aromatic amino acid decarboxylase activity using recombinant adeno-associated viral vector gene transfer in a rodent model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adeno-associated virus-mediated gene transfer to the brain: duration and modulation of expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The efficiency of systematic sampling in stereology and its prediction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical localization in the rat brain of an epitope corresponding to the fibroblast growth factor receptor-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficient transduction of green fluorescent protein in spinal cord neurons using adeno-associated virus vectors containing cell type-specific promoters

1 reference

https://pubmed.ncbi.nlm.nih.gov/10844038

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.20-12-04686.2000

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7 November 2019

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Europe PubMed Central

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7 November 2019

1 reference

Europe PubMed Central

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7 November 2019

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