Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase. (Q40875506)

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7 November 2019

title

Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase (English)

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7 November 2019

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3

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7 November 2019

author name string

S J Weedon

1

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7 November 2019

N K Green

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7 November 2019

M G Gilligan

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7 November 2019

V Mautner

5

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7 November 2019

C J Wrighton

6

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7 November 2019

A Mountain

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7 November 2019

L S Young

8

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D J Kerr

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P F Searle

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7 November 2019

language of work or name

English

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publication date

1 June 2000

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International Journal of Cancer

7 November 2019

published in

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7 November 2019

volume

86

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7 November 2019

issue

6

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7 November 2019

page(s)

848-854

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The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--I. Purification and properties of a nitroreductase enzyme from Escherichia coli--a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT).

7 November 2019

cites work

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The bystander effect of the nitroreductase/CB1954 enzyme/prodrug system is due to a cell-permeable metabolite

21 January 2018

1 reference

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Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954.

21 January 2018

1 reference

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Selective cell ablation in transgenic mice expression E. coli nitroreductase

21 January 2018

1 reference

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The expression of bacterial nitroreductase in transgenic mice results in specific cell killing by the prodrug CB1954.

21 January 2018

1 reference

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Adenoviral delivery of B7-1 (CD80) increases the immunogenicity of human ovarian and cervical carcinoma cells

21 January 2018

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Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy

21 January 2018

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Bioactivation of CB 1954: reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand crosslinking species

21 January 2018

1 reference

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Virus directed enzyme prodrug therapy for ovarian and pancreatic cancer using retrovirally delivered E. coli nitroreductase and CB1954.

21 January 2018

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Gene directed enzyme prodrug therapy for cancer.

21 January 2018

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Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system

21 January 2018

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Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vector

21 January 2018

1 reference

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A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells

21 January 2018

1 reference

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The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase

21 January 2018

1 reference

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CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells

21 January 2018

1 reference

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10.1002/(SICI)1097-0215(20000615)86:6<848::AID-IJC14>3.0.CO;2-B

21 January 2018

Identifiers

DOI

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7 November 2019

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